{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:19:45Z","timestamp":1761110385418},"reference-count":29,"publisher":"Scientific Scholar","content-domain":{"domain":["clinicalimagingscience.org"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Aim:<\/jats:title>\n<jats:p>The purpose of the study was to analyze and summarize the computed tomography (CT) and magnetic resonance imaging (MRI) findings of spinal monostotic fibrous dysplasia (MFD) as well as evaluate the clinical value of CT and MRI in MFD diagnosis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Materials and Methods:<\/jats:title>\n<jats:p>CT (<jats:italic>n<\/jats:italic> = 4) and MRI (<jats:italic>n<\/jats:italic> = 5) images of six patients with pathologically confirmed spinal MFD were examined. The assessed image features included location, shape, rib involvement, vertebral collapse, margin, attenuation, and sclerotic rim on CT, as well as signal intensity, dark signal rim, and enhancement pattern on MRI.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Results:<\/jats:title>\n<jats:p>In total, four of six patients underwent CT scanning. The most common findings on CT scanning were expansile lesions (<jats:italic>n<\/jats:italic> = 4), sclerotic rims (<jats:italic>n<\/jats:italic> = 4), and ground-glass opacity (GGO) (<jats:italic>n<\/jats:italic> = 4). In total, five of six patients underwent MRI. The lesions were low-signal intensity (<jats:italic>n<\/jats:italic> = 2), low-to-isointense signal intensity (<jats:italic>n<\/jats:italic> = 1), and low-signal intensity with several isointense portions (<jats:italic>n<\/jats:italic> = 2) on T1-weighted imaging (T1WI). The lesions were low-signal intensity (<jats:italic>n<\/jats:italic> = 1), isointense to high intensity (<jats:italic>n<\/jats:italic> = 1), and isointense signal intensity with several high portions (<jats:italic>n<\/jats:italic> = 3) on T2WI. A dark signal rim was found in most cases on T1WI and T2WI (<jats:italic>n<\/jats:italic> = 4). The lesions (<jats:italic>n<\/jats:italic> = 2) showed obvious enhancement.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st4\">\n<jats:title>Conclusions:<\/jats:title>\n<jats:p>The CT and MRI manifestations of spinal MFD have the following characteristics: expansile lesion, GGO, sclerotic rim, and no obvious soft-tissue mass. The combined use of CT and MRI examinations is necessary for patients with suspected spinal MFD.<\/jats:p>\n<\/jats:sec>","DOI":"10.4103\/jcis.jcis_20_18","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T09:24:13Z","timestamp":1529313853000},"page":"23","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Computed Tomography and Magnetic Resonance Imaging Manifestations of Spinal Monostotic Fibrous Dysplasia"],"prefix":"10.25259","volume":"8","author":[{"given":"Yu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaohua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hexiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yupeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dapeng","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2018,6,18]]},"reference":[{"key":"10.4103\/jcis.JCIS_20_18\/ref-1","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1001\/archsurg.1938.01190230153012","article-title":"Polyostotic fibrous dysplasia","volume":"36","author":"Lichtenstein","year":"1938","journal-title":"Arch Surg"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-2","first-page":"777","article-title":"Fibrous dysplasia of bone","volume":"33","author":"Lichtenstein","year":"1942","journal-title":"Arch Pathol"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-3","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1259\/bjr\/81329736","article-title":"CT and MRI of fibrous dysplasia of the spine","volume":"85","author":"Park","year":"2012","journal-title":"Br J Radiol"},{"issue":"Suppl 2","key":"10.4103\/jcis.JCIS_20_18\/ref-4","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s00586-008-0806-7","article-title":"Treatment of osteoblastoma at C7: A multidisciplinary approach. A case report and review of the literature","volume":"18","author":"Samdani","year":"2009","journal-title":"Eur Spine J"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-5","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1097\/BRS.0b013e3182a8cc05","article-title":"Fibrous dysplasia of the mobile spine: Report of 8 cases and review of the literature","volume":"38","author":"Wu","year":"2013","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2106\/00004623-196244020-00001","article-title":"The natural history of fibrous dysplasia. An orthopaedic, pathological, and roentgenographic study","volume":"44-A","author":"Harris","year":"1962","journal-title":"J Bone Joint Surg Am"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-7","first-page":"82","article-title":"A rare case of monostotic spinal fibrous dysplasia mimicking solitary metastatic lesion of thyroid carcinoma","volume":"23","author":"Sharifudin","year":"2016","journal-title":"Malays J Med Sci"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-8","first-page":"1848","article-title":"Fibrous dysplasia. Pathophysiology, evaluation, and treatment","volume":"87","author":"DiCaprio","year":"2005","journal-title":"J Bone Joint Surg Am"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-9","first-page":"155","article-title":"Natural history and treatment of fibrous dysplasia of bone: A multicenter clinicopathologic study promoted by the european pediatric orthopaedic society","volume":"12","author":"Ippolito","year":"2003","journal-title":"J Pediatr Orthop B"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-10","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3233\/BMR-150647","article-title":"Monostotic fibrous dysplasia of the thoracic spine: A case report","volume":"29","author":"Ren","year":"2016","journal-title":"J Back Musculoskelet Rehabil"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-11","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.jbspin.2005.11.016","article-title":"Symptomatic polyostotic fibrous dysplasia of the thoracic spine","volume":"73","author":"Tezer","year":"2006","journal-title":"Joint Bone Spine"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-12","doi-asserted-by":"crossref","first-page":"984","DOI":"10.2106\/JBJS.I.00727","article-title":"Monostotic fibrous dysplasia of the spine: A report of seven cases","volume":"92","author":"Schoenfeld","year":"2010","journal-title":"J Bone Joint Surg Am"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-13","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/s11596-007-0617-9","article-title":"Imaging diagnosis of monostotic fibrous dysplasia in thoracic and lumbar spine vertebrae","volume":"27","author":"Yang","year":"2007","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-14","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.2106\/JBJS.J.01881","article-title":"Twenty-year follow-up of monostotic fibrous dysplasia of the second cervical vertebra: A case report and review of the literature","volume":"93","author":"Meredith","year":"2011","journal-title":"J Bone Joint Surg Am"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-15","first-page":"711","article-title":"Monostotic fibrous dysplasia of the thoracic spine with malignant transformation","volume":"103","author":"Fu","year":"2004","journal-title":"J Formos Med Assoc"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-16","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1097\/SCS.0b013e3181d08ca8","article-title":"Malignant transformation of monostotic fibrous dysplasia in the mandible","volume":"21","author":"Kim","year":"2010","journal-title":"J Craniofac Surg"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-17","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.2214\/ajr.182.6.1821389","article-title":"Imaging findings of fibrous dysplasia with histopathologic and intraoperative correlation","volume":"182","author":"Fitzpatrick","year":"2004","journal-title":"AJR Am J Roentgenol"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-18","doi-asserted-by":"crossref","first-page":"305","DOI":"10.5435\/00124635-200409000-00005","article-title":"Fibrous dysplasia","volume":"12","author":"Parekh","year":"2004","journal-title":"J Am Acad Orthop Surg"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-19","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0009-9260(88)80222-8","article-title":"Fibrous dysplasia of the spine","volume":"39","author":"Wright","year":"1988","journal-title":"Clin Radiol"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-20","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1097\/00007632-199208000-00020","article-title":"Fibrous dysplasia of the spine","volume":"17","author":"Ehara","year":"1992","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-21","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s11547-013-0352-1","article-title":"Giant cell tumours of the mobile spine: Characteristic imaging features and differential diagnosis","volume":"119","author":"Si","year":"2014","journal-title":"Radiol Med"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-22","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/s00381-015-2991-0","article-title":"A thoracic spinal bone giant cell tumor in a skeletally immature girl. A case report and literature review","volume":"32","author":"Sigwalt","year":"2016","journal-title":"Childs Nerv Syst"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-23","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1055\/s-0034-1396433","article-title":"Pediatric upper cervical spine giant cell tumor: Case report","volume":"5","author":"Alfawareh","year":"2015","journal-title":"Global Spine J"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-24","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00256-014-2035-y","article-title":"A systematic approach to vertebral hemangioma","volume":"44","author":"Gaudino","year":"2015","journal-title":"Skeletal Radiol"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-25","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s005860050167","article-title":"Acute spinal cord compression due to intraspinal bleeding from a vertebral hemangioma: Two case-reports","volume":"8","author":"Castel","year":"1999","journal-title":"Eur Spine J"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-26","doi-asserted-by":"crossref","first-page":"805","DOI":"10.12659\/AJCR.898562","article-title":"A symptomatic case of thoracic vertebral hemangioma causing lower limb spastic paresis","volume":"17","author":"Alfawareh","year":"2016","journal-title":"Am J Case Rep"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-27","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/BPO.0000000000000365","article-title":"Aneurysmal bone cyst of the cervical spine in children: A review and a focus on available treatment options","volume":"35","author":"Sebaaly","year":"2015","journal-title":"J Pediatr Orthop"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-28","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00247-001-0648-5","article-title":"Spinal aneurysmal bone cyst causing acute cord compression without vertebral collapse: CT and MRI findings","volume":"32","author":"Chan","year":"2002","journal-title":"Pediatr Radiol"},{"key":"10.4103\/jcis.JCIS_20_18\/ref-29","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4103\/1793-5482.161179","article-title":"Aneurysmal bone cyst of the lumbar spine","volume":"10","author":"Cugati","year":"2015","journal-title":"Asian J Neurosurg"}],"container-title":["Journal of Clinical Imaging Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/clinicalimagingscience.org\/computed-tomography-and-magnetic-resonance-imaging-manifestations-of-spinal-monostotic-fibrous-dysplasia\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/clinicalimagingscience.org\/computed-tomography-and-magnetic-resonance-imaging-manifestations-of-spinal-monostotic-fibrous-dysplasia\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T11:58:51Z","timestamp":1565956731000},"score":1,"resource":{"primary":{"URL":"https:\/\/clinicalimagingscience.org\/computed-tomography-and-magnetic-resonance-imaging-manifestations-of-spinal-monostotic-fibrous-dysplasia\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,18]]},"references-count":29,"alternative-id":["10.4103\/jcis.JCIS_20_18"],"URL":"https:\/\/doi.org\/10.4103\/jcis.jcis_20_18","relation":{},"ISSN":["2156-7514"],"issn-type":[{"value":"2156-7514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,18]]},"article-number":"23"}}