{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:45:29Z","timestamp":1788587129890,"version":"build-2803163510"},"reference-count":5,"publisher":"Scientific Scholar","content-domain":{"domain":["clinicalimagingscience.org"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>Waardenburg syndrome (WS) is a rare genetic disorder secondary to neural crest cell developmental abnormalities. It is predominantly described as an auditory\u2013pigmentary syndrome with diverse patient presentation, typically involving congenital sensorineural hearing loss and pigmentation abnormalities of the skin, hair, and iris. Other developmental abnormalities that may be associated with this syndrome are Hirschsprung's disease and a myriad of cardiovascular congenital defects. We present a case of a young girl with WS who found to have a persistent left superior vena cava (PLSVC) draining into the coronary sinus. The prevalence of PLSVC is increased in patients with chromosomal and genetic abnormalities. However, we are the first to report its presence in association with WS while discussing the challenges that may arise during central venous catheter placement in patients with PLSVC.<\/jats:p>","DOI":"10.4103\/jcis.jcis_31_18","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T04:21:55Z","timestamp":1542255715000},"page":"44","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Waardenburg Syndrome and Left Persistent Superior Vena Cava"],"prefix":"10.25259","volume":"8","author":[{"given":"Driss","family":"Raissi","sequence":"first","affiliation":[{"name":"Department of Radiology, University of Kentucky, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Christie","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Kentucky, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Applegate","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Kentucky, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2018,11,15]]},"reference":[{"key":"10.4103\/jcis.JCIS_31_18\/ref-1","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1136\/jmg.34.8.656","article-title":"Waardenburg syndrome","volume":"34","author":"Read","year":"1997","journal-title":"J Med Genet"},{"key":"10.4103\/jcis.JCIS_31_18\/ref-2","first-page":"657","article-title":"Waardenburg's syndrome and severe cyanotic cardiopathy","volume":"47","author":"Mathieu","year":"1990","journal-title":"Arch Fr Pediatr"},{"key":"10.4103\/jcis.JCIS_31_18\/ref-3","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.ijporl.2014.05.020","article-title":"Inner ear anatomy in Waardenburg syndrome: Radiological assessment and comparison with normative data","volume":"78","author":"Kontorinis","year":"2014","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"10.4103\/jcis.JCIS_31_18\/ref-4","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1177\/002013240004500406","article-title":"Persistent left superior vena cava: Case report and literature review","volume":"45","author":"Sarodia","year":"2000","journal-title":"Respir Care"},{"key":"10.4103\/jcis.JCIS_31_18\/ref-5","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/pd.4380","article-title":"Fetal persistent left superior vena cava in cases with and without chromosomal anomalies","volume":"34","author":"Du","year":"2014","journal-title":"Prenat Diagn"}],"container-title":["Journal of Clinical Imaging Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/clinicalimagingscience.org\/waardenburg-syndrome-and-left-persistent-superior-vena-cava\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/clinicalimagingscience.org\/waardenburg-syndrome-and-left-persistent-superior-vena-cava\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T02:19:16Z","timestamp":1775269156000},"score":1,"resource":{"primary":{"URL":"https:\/\/clinicalimagingscience.org\/waardenburg-syndrome-and-left-persistent-superior-vena-cava\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,15]]},"references-count":5,"alternative-id":["10.4103\/jcis.JCIS_31_18"],"URL":"https:\/\/doi.org\/10.4103\/jcis.jcis_31_18","relation":{},"ISSN":["2156-7514"],"issn-type":[{"value":"2156-7514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,15]]},"article-number":"44"}}