{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:03:23Z","timestamp":1790078603603,"version":"4.0.1"},"reference-count":27,"publisher":"Scientific Scholar","content-domain":{"domain":["clinicalimagingscience.org"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\"><jats:title>Objectives:<\/jats:title><jats:p>We aimed to prospectively assess the diagnostic value of apparent diffusion coefficient (ADC) measurement in the differentiation of benign and malignant mediastinal lymphadenopathies.<\/jats:p><\/jats:sec><jats:sec id=\"st2\"><jats:title>Materials and Methods:<\/jats:title><jats:p>The study included 63 consecutive patients (28 women, 35 men; mean age 59.3 years) with 125 mediastinal lymphadenopathies. Echoplanar diffusion-weighted magnetic resonance imaging of the mediastinum was performed with b-factors of 0 and 600 mm<jats:sup>2<\/jats:sup>\/s before mediastinoscopy and mediastinotomy, and ADC values were measured. The ADC values were compared with the histological results, and statistical analysis was done.<jats:italic>P<\/jats:italic>&lt; 0.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec id=\"st3\"><jats:title>Results:<\/jats:title><jats:p>The mean ADC value of malignant mediastinal lymphadenopathy (1.030 \u00b1 0.245 \u00d7 10<jats:sup>\u22123<\/jats:sup>mm<jats:sup>2<\/jats:sup>\/s) was significantly lower (<jats:italic>P<\/jats:italic>&lt; 0.05) when compared to benign lymphadenopathies (1.571 \u00b1 0.559 \u00d7 10<jats:sup>\u22123<\/jats:sup>mm<jats:sup>2<\/jats:sup>\/s). For differentiating malignant from benign mediastinal lymphadenopathy, the best result was obtained when an ADC value of 1.334 \u00d7 10<jats:sup>\u22123<\/jats:sup>mm<jats:sup>2<\/jats:sup>\/s was used as a threshold value; area under the curve 0.848, accuracy 78.4%, sensitivity 66%, specificity of 86%, positive predictive value 76.7%, and negative predictive value of 79.2%. Interobserver agreement was excellent for ADC measurements.<\/jats:p><\/jats:sec><jats:sec id=\"st4\"><jats:title>Conclusions:<\/jats:title><jats:p>ADC measurements could be considered an important supportive method in differentiating benign from malignant mediastinal lymphadenopathies.<\/jats:p><\/jats:sec>","DOI":"10.4103\/jcis.jcis_84_16","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T08:26:46Z","timestamp":1488788806000},"page":"12","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Apparent Diffusion Coefficient Measurement in Mediastinal Lymphadenopathies: Differentiation between Benign and Malignant Lesions"],"prefix":"10.25259","volume":"7","author":[{"given":"Fethi Emre","family":"Ustabasioglu","sequence":"first","affiliation":[{"name":"Department of Radiology, Cerrahpasa Faculty of Medicine, Istanbul University, K.M. 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