{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:19:42Z","timestamp":1787840382124,"version":"build-2784847793"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Primary signet ring cell carcinoma (SRCC) of the breast is a rare and aggressive type of breast cancer characterized by increased intracellular mucin production. It has a high risk of metastasis and poor prognosis compared to other breast cancer types. We report a 56-year-old woman with primary SRCC of the breast who first presented with retraction on her left breast. Radiological examination revealed a mass that causes the retraction. The patient underwent left modified radical mastectomy, and pathology results showed a 70% signet ring cell pattern. Chemotherapy consists of an adriamycin-cyclophosphamide regimen administered. in this case, we aim to review the literature on this topic and inform the physicians.<\/jats:p>","DOI":"10.4103\/jcrt.jcrt_1963_22","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T10:01:59Z","timestamp":1728295319000},"page":"1615-1617","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Primary signet ring cell carcinoma of the breast: A case report and literature review"],"prefix":"10.4103","volume":"20","author":[{"given":"El\u00e7in","family":"Kasapo\u011flu","sequence":"first","affiliation":[{"name":"Trakya University School of Medicine, Edime, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berfin","family":"Kandil","sequence":"additional","affiliation":[{"name":"Trakya University School of Medicine, Edime, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"G\u00f6kyer","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, K\u0131rklareli Education and Research Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sernaz","family":"Uzuno\u011flu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Trakya University Education and Research Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,4,4]]},"reference":[{"key":"R1-20241226","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1097\/00000478-200012000-00009","article-title":"Pleomorphic lobular carcinoma:Morphology, immunohistochemistry, and molecular analysis","volume":"24","author":"Middleton","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"R2-20241226","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/17474124.2018.1416291","article-title":"Survival in signet ring cell carcinoma varies based on primary tumor location:A surveillance, epidemiology, and end results database analysis","volume":"12","author":"Wu","year":"2018","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"R3-20241226","first-page":"64","article-title":"The significance of signet ring cells in infiltrating lobular carcinoma of the breast","volume":"119","author":"Frost","year":"1995","journal-title":"Arch Pathol Lab Med"},{"key":"R4-20241226","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/S0002-9440(10)65385-0","article-title":"alpha-catenin-deficient F9 cells differentiate into signet ring cells","volume":"154","author":"Maeno","year":"1999","journal-title":"Am J Pathol"},{"key":"R6-20241226","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/1097-0142(197602)37:2<828::AID-CNCR2820370231>3.0.CO;2-N","article-title":"Signet-ring cell carcinoma of the breast. 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