{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:35:59Z","timestamp":1787070959329,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Despite the availability of a wide range of agents, no single treatment exists for the management of radiation-induced oral mucositis, in patients, with head and neck malignancies, on radical chemoradiation; a debilitating and limiting sequela. Human placental extract is one option that has been proposed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims and Objectives:<\/jats:title>\n                    <jats:p>This study aimed at evaluating the therapeutic benefits of human placental extract (Placentrex) in the management of radiation-induced oral mucositis in patients on curative intent treatment for head and neck cancers with concurrent chemoradiation, and to compare the observations with other conventional approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>\n                      Patients presenting to the Department of Radiation Oncology, of a tertiary cancer care center, with biopsy-proven carcinoma of the oral cavity, oropharynx, and hypopharynx, planned for definitive, curative intent chemoradiation, between January 2020 and June 2021, were recruited for this study. The interventional group received a deep intramuscular injection of 2 ml of Placentrex to the deltoid muscle, once-a-day from the 11\n                      <jats:sup>th<\/jats:sup>\n                      fraction of radiation till completion, on treatment and non-treatment days. The control group received supportive, symptomatic, conventional treatments for mucositis. The response was assessed every week during treatment and at the third and sixth months of follow-up and was compared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The study comprised 26 patients, 15 in the interventional group and 11 in the control group. On completion of treatment, 40% in the interventional arm and 81.82% in the control arm had progressed to grade 2 and 3 mucositis (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). Treatment interruption was seen in 13% in the interventional arm and 55% in the control arm (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Results from this study show that human placental extract, injection Placentrex, had a significant effect in decreasing the severity of radiation-induced mucositis and thereby reducing any interruption or delay in treatment when compared to other conventional methods.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jcrt.jcrt_2017_22","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T17:52:06Z","timestamp":1719510726000},"page":"776-781","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Intramuscular injections of human placental extract versus conventional symptomatic approaches in radiation-induced oral mucositis, in patients with head and neck cancers, on definitive chemoradiotherapy \u2013 A ray of hope?"],"prefix":"10.4103","volume":"20","author":[{"given":"Priyanka Manchenahalli Venkatesh","family":"Prasad","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prameela G.","family":"Chelakkot","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetha S.","family":"Narayan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,4,5]]},"reference":[{"key":"R1-20241021","first-page":"1738932","article-title":"Epidemiological trends of head and neck cancer: A population-based study","author":"Guo","year":"2021","journal-title":"Biomed Res Int 2021"},{"key":"R3-20241021","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ijom.2011.10.011","article-title":"Cancer treatment-induced oral mucositis: A critical review","volume":"41","author":"Rodr\u00edguez-Caballero","year":"2012","journal-title":"Int J Oral Maxillofac Surg"},{"key":"R4-20241021","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3322\/canjclin.51.5.290","article-title":"Oral mucositis complicating chemotherapy and\/or radiotherapy: Options for prevention and treatment","volume":"51","author":"Kostler","year":"2001","journal-title":"CA Cancer J Clin"},{"key":"R5-20241021","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2174\/1574887115666200731182708","article-title":"Radiation-induced oral mucositis in head and neck cancer patients. 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