{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:56:16Z","timestamp":1791381376147,"version":"4.3.3"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To retrospectively access outcome, adverse events and prognostic factors in oropharyngeal carcinoma (OPC) patients treated with intensity-modulated radiotherapy (IMRT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Ninety-eight OPC patients were treated between 2000 and 2015. Thirty-three patients received definitive and 65 adjuvant radiotherapy. Seventy-one percent had simultaneous chemotherapy. Patients were systematically followed up (mean 114 months, range 19\u2013197 months). Statistical analysis used Kaplan\u2013Meier method, Cox regression analysis, and log-rank test. Adverse events were classified according to common toxicity criteria version (CTCAE) 4.03.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The 1-, 5-, and 10-year overall survival rates in the adjuvant vs. definitive cohort were 90.8% vs. 66.7%, 67.4% vs. 33.1%, and 57.7% vs. 16.5%. Survival in the adjuvant cohort was significantly longer than in the definitive cohort (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.00005). Patients &lt;65 years had a significantly longer survival than older patients. Locoregional tumor control rates after 1-, 5-, and 10 years in the adjuvant vs. definitive cohort were 90.2% vs. 66.7%, 82.2% vs 45.4%, and 72.1% vs. 30.3%. Locoregional tumor control in the adjuvant cohort was significantly longer than in the definite cohort (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.005). Distant metastases were diagnosed in 20.4% of all patients. Most patients had mild CTCAE grade 1 and 2 adverse events and mild late adverse events including xerostomia, dysphagia, and lymphedema.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Intensity-modulated radiotherapy for OPC is an important part of the treatment algorithm alone and in particular after surgery while the additional benefits of chemotherapy might be age dependent. Despite advanced tumor stages, nearly half of our patients were alive in the long term. The majority of patients had relatively mild chronic adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jcrt.jcrt_2178_22","type":"journal-article","created":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T15:01:53Z","timestamp":1711810913000},"page":"375-382","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Primary and adjuvant intensity-modulated radiotherapy in oropharyngeal carcinoma patients from a single institution"],"prefix":"10.4103","volume":"20","author":[{"given":"Henrik","family":"Hauswald","sequence":"first","affiliation":[{"name":"Clinical Cooperation Unit Molecular Radiation Oncology (E055), German Cancer Research Center (DKFZ), Heidelberg, Germany"},{"name":"RNS Gemeinschaftspraxis, Wiesbaden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugen","family":"Petrow","sequence":"additional","affiliation":[{"name":"Clinical Cooperation Unit Molecular Radiation Oncology (E055), German Cancer Research Center (DKFZ), Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falk","family":"Roeder","sequence":"additional","affiliation":[{"name":"Clinical Cooperation Unit Molecular Radiation Oncology (E055), German Cancer Research Center (DKFZ), Heidelberg, Germany"},{"name":"Department of Radiotherapy and Radiation Oncology, Paracelsus Medical University Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen","family":"Debus","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Zwicker","sequence":"additional","affiliation":[{"name":"Clinical Cooperation Unit Molecular Radiation Oncology (E055), German Cancer Research Center (DKFZ), Heidelberg, Germany"},{"name":"Praxis Prof. Dr. H. Zwicker und Kollegen, Konstanz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E.","family":"Huber","sequence":"additional","affiliation":[{"name":"Clinical Cooperation Unit Molecular Radiation Oncology (E055), German Cancer Research Center (DKFZ), Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,4,4]]},"reference":[{"key":"R3-20260507","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/ijc.2910340504","article-title":"Alcohol, smoking, social and occupational factors in the aetiology of cancer of the oral cavity, pharynx and larynx","volume":"34","author":"Elwood","year":"1984","journal-title":"Int J Cancer"},{"key":"R4-20260507","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1093\/ije\/dyw069","article-title":"Combined effects of smoking and HPV16 in oropharyngeal cancer","volume":"45","author":"Anantharaman","year":"2016","journal-title":"Int J 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