{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:03:21Z","timestamp":1790402601547,"version":"4.1.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cervical cancer is the second most common cancer among females worldwide. The role of platelets in cancer progression and metastasis have been evaluated in various cancers. This study is done to assess the association between platelet parameters and invasive squamous cell carcinoma of the cervix.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Eighty cases of squamous cell carcinoma of the cervix were retrospectively collected from the medical record department. Values of platelet parameters such as platelet count, mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), platelet-large cell ratio (P-LCR), platelet-lymphocyte ratio (PLR), platelet-neutrophil ratio (PNR), and platelet-monocyte ratio (PMR) are collected from automated hematology analyzer. These values were compared with 80 healthy controls which were randomly selected. Values of platelet parameters were also compared among Federation Internationale de Gynecolgie et d\u2019Obstetrique (FIGO) stages in 80 cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result:<\/jats:title>\n                    <jats:p>Mean \u00b1 standard deviation (SD) for platelet count, MPV, PDW, PCT, P-LCR, PLR, PNR, and PMR among cases were 316 \u00b1 100.37 \u00d7 109\/L, 9.98 \u00b1 0.96, 11.11 \u00b1 2.27, 0.31 \u00b1 0.092, 24.09 \u00b1 7.62, 179.35 \u00b1 85.53, 63.89 \u00b1 42.10, and 492.29 \u00b1 192.86, respectively, and in controls were 300.30 \u00b1 79.40 \u00d7 109\/L, 9.97 \u00b1 0.83, 10.97 \u00b1 1.80, 0.59 \u00b1 2.65, 23.94 \u00b1 6.81, 137.72 \u00b1 50.52, 60.07 \u00b1 26.68, and 563.65 \u00b1 602.55, respectively. The PLR between cases and controls was statistically significant. The platelet count and PCT between stages was statistically significant wherein the values increased from stage II to stage IV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Platelet parameters are importance in cervical cancer. PLR, platelet count, and PCT are platelet parameters that can be used as predictors and prognostic parameters in cervical cancer. These parameters are cost-effective and can be considered in low resource settings. However, a multicentric study with a larger sample size should be done to extrapolate the findings for patient care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jcrt.jcrt_217_22","type":"journal-article","created":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T15:01:59Z","timestamp":1711810919000},"page":"139-143","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Significance of platelet parameters in invasive squamous cell carcinoma of uterine cervix"],"prefix":"10.4103","volume":"20","author":[{"given":"Ankit","family":"Anand","sequence":"first","affiliation":[{"name":"Department of Pathology, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalyani","family":"Raju","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sri Devaraj Urs Medical 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