{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:33:50Z","timestamp":1787070830089,"version":"build-2736575974"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Breast cancer in young women is associated with aggressive biology. We analyzed histopathological and clinical properties of breast cancer patients diagnosed at \u226440 years of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Breast cancer patients who were admitted between 2015 and 2019 were included. Baseline characteristics of the patients with treatment-related outcomes were assessed. The study group was divided into two subgroups; &lt;35 years old as \u201cvery young\u201d and \u226535 years old as \u201cyoung.\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The data of 137 patients (60 patients &lt;35 years) were reviewed. The mean age was 34.7 years. The mean follow-up duration was 44.45 \u00b1 26.39 months, and the mean disease-free survival was 36.17 \u00b1 21.97 months. 11.4% of the patients were diagnosed with Stage 4 disease. Pathologic subtype was invasive ductal carcinoma in 86% of patients. 16.8% of the patients were luminal A, 38.7% luminal B, 30.5% were human epidermal growth factor receptor-2\u2013positive type, and 15.3% were triple-negative. Only 5 (3.3%) patients had given birth after chemotherapy. During the follow-up period of early-staged diagnosed patients, metastatic disease occurred in 24.6%. The rate of distant metastasis development was statistically higher in the very young group (31% vs. 11%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.004). Thirteen patients (10.7%) died due to disease progression. Thirty-seven percent of the patients had a positive family history for either breast or ovarian cancer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Very young breast cancer patients seem to have a more aggressive disease course. The low rate of childbearing in this young patient population is conspicuous. An interdisciplinary approach for the management of this special patient population should be taken into consideration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jcrt.jcrt_545_20","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T08:33:31Z","timestamp":1626424411000},"page":"1322-1327","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":18,"title":["Breast cancer in young and very young women; Is age related to outcome?"],"prefix":"10.4103","volume":"17","author":[{"given":"Okan","family":"Avci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seher Yildiz","family":"Tacar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdogan Selcuk","family":"Seber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarkan","family":"Yetisyigit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20241021","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.breast.2009.12.002","article-title":"Breast cancer in women under 40 years of age: A series of 57 cases from Northern Ireland","volume":"19","author":"McAree","year":"2010","journal-title":"Breast"},{"key":"R2-6-20241021","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s10549-011-1872-9","article-title":"Pathologic features and molecular phenotype by patient age in a large cohort of young women with breast cancer","volume":"131","author":"Collins","year":"2012","journal-title":"Breast Cancer Res Treat"},{"key":"R3-6-20241021","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12905-017-0456-1","article-title":"Clinicopathologic and prognostic features of breast cancer in young women: A series from North of Morocco","volume":"17","author":"Bakkach","year":"2017","journal-title":"BMC Womens Health"},{"key":"R4-6-20241021","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s10549-009-0388-z","article-title":"Korean Breast Cancer Society. 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