{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:37:21Z","timestamp":1787071041608,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>\n                    A case of signet ring cell lymphoma of presacral lymph node is reported. The patient was diagnosed as follicular lymphoma on the basis of clinical and laboratory features, including immunohistochemistry (IHC) and gene rearrangement studies. Light microscopy examination showed neoplastic atypical cells with signet ring cell morphology in core biopsy of lymph node that stained for B-cell markers by IHC. In addition, the neoplastic cells expressed CD20, CD10, BCL-2, and BCL-6, indicating follicular center origin. Fluorescence\n                    <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                    hybridization study demonstrated BCL2 gene arrangement. Especially in the case of deep-seated intra-abdominal lymph nodes with atypical presentation, the differential diagnosis arises with nonhemopoietic tumors, and this needs to be distinguished by specific immunostaining and gene arrangement studies.\n                  <\/jats:p>","DOI":"10.4103\/jcrt.jcrt_676_19","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T04:21:26Z","timestamp":1655871686000},"page":"807-811","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Signet ring cell lymphoma of follicular type with BCL2 gene rearrangement: A rare case with a short review of literature"],"prefix":"10.4103","volume":"18","author":[{"given":"Pritinanda","family":"Mishra","sequence":"first","affiliation":[{"name":"Department of Pathology and Lab Medicine, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit Kumar","family":"Adhya","sequence":"additional","affiliation":[{"name":"Department of Pathology and Lab Medicine, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhabananda","family":"Kar","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayur","family":"Parihar","sequence":"additional","affiliation":[{"name":"Department of Cytogenetics, Tata Memorial Center, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swagatika","family":"Samal","sequence":"additional","affiliation":[{"name":"Department of Pathology and Lab Medicine, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukund","family":"Sable","sequence":"additional","affiliation":[{"name":"Department of Pathology and Lab Medicine, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"key":"R2-20250514","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/00000478-197806000-00001","article-title":"Signet ring cell lymphoma. A rare morphologic and functional expression of nodular (follicular) lymphoma","volume":"2","author":"Kim","year":"1978","journal-title":"Am J Surg Pathol"},{"key":"R3-20250514","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3109\/01913128309141839","article-title":"Signet-ring cell variant of large cell lymphoma","volume":"5","author":"Dardick","year":"1983","journal-title":"Ultrastruct Pathol"},{"key":"R4-20250514","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S1092-9134(99)80054-9","article-title":"Signet-ring cell variant of small lymphocytic lymphoma with a prominent sinusoidal pattern","volume":"3","author":"Ramnani","year":"1999","journal-title":"Ann Diagn Pathol"},{"key":"R5-20250514","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1097\/00000478-199605000-00005","article-title":"Carcinoma-like signet-ring cells in gastric mucosa-associated lymphoid tissue (MALT) lymphoma","volume":"20","author":"Zamboni","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"R6-20250514","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1365-2559.1991.tb01491.x","article-title":"Multiple myeloma showing signet-ring cell change","volume":"18","author":"Dorfman","year":"1991","journal-title":"Histopathology"},{"key":"R7-20250514","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1136\/jcp.42.3.239","article-title":"Signet ring cell lymphoma of T cell type","volume":"42","author":"Cross","year":"1989","journal-title":"J Clin Pathol"},{"key":"R8-20250514","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1046\/j.1365-2559.1997.d01-565.x","article-title":"CD30+ anaplastic large-cell lymphoma, null type, with signet-ring appearance","volume":"30","author":"Falini","year":"1997","journal-title":"Histopathology"},{"key":"R9-20250514","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/ajcp\/69.1.306","article-title":"Immunoglobulin inclusions in non-Hodgkin's lymphomas","volume":"69","author":"van den Tweel","year":"1978","journal-title":"Am J Clin Pathol"},{"key":"R10-20250514","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3109\/00313028009060060","article-title":"Signet ring cell lymphoma: A case report","volume":"12","author":"Moir","year":"1980","journal-title":"Pathology"},{"key":"R11-20250514","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3109\/01913128009140558","article-title":"Signet-ring cell lymphoma","volume":"1","author":"Iossifides","year":"1980","journal-title":"Ultrastruct Pathol"},{"key":"R12-20250514","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1136\/jcp.34.8.884","article-title":"Signet ring cell lymphoma: A rare variant of follicular lymphoma","volume":"34","author":"Harris","year":"1981","journal-title":"J Clin Pathol"},{"key":"R13-20250514","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1365-2559.1981.tb01775.x","article-title":"Signet ring cell lymphoma: A case report","volume":"5","author":"Pileri","year":"1981","journal-title":"Histopathology"},{"key":"R14-20250514","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1002\/1097-0142(19831101)52:9<1613::AID-CNCR2820520913>3.0.CO;2-V","article-title":"Signet-ring cell lymphoma. Ultrastructural and immunohistochemical features of three varieties","volume":"52","author":"Navas-Palacios","year":"1983","journal-title":"Cancer"},{"key":"R15-20250514","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1093\/ajcp\/81.3.358","article-title":"Signet ring cell lymphoma. A report of a case and review of the literature","volume":"81","author":"Silberman","year":"1984","journal-title":"Am J Clin Pathol"},{"key":"R16-20250514","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/S0046-8177(85)80286-0","article-title":"Signet ring cell lymphoma of the thyroid: A case report","volume":"16","author":"Allevato","year":"1985","journal-title":"Hum Pathol"},{"key":"R17-20250514","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S0190-9622(86)70040-6","article-title":"Signet ring lymphoma of the skin: Ultrastructural and immunohistochemical features","volume":"14","author":"Hanna","year":"1986","journal-title":"J Am Acad Dermatol"},{"key":"R18-20250514","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.2169\/internalmedicine.42.1055","article-title":"Signet-ring cell lymphoma","volume":"42","author":"Nagasaki","year":"2003","journal-title":"Intern Med"},{"key":"R19-20250514","doi-asserted-by":"crossref","first-page":"e416","DOI":"10.1200\/JCO.2010.33.4821","article-title":"Signet ring cell lymphoma in a patient with elevated CA-125","volume":"29","author":"Coffing","year":"2011","journal-title":"J Clin Oncol"},{"key":"R20-20250514","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/PGP.0b013e31823b6f6a","article-title":"An unusual uterine tumor with signet ring cell features","volume":"31","author":"Sarro","year":"2012","journal-title":"Int J Gynecol Pathol"},{"key":"R21-20250514","doi-asserted-by":"crossref","first-page":"491","DOI":"10.5001\/omj.2012.117","article-title":"Signet ring cell lymphoma of the small bowel: A case report","volume":"27","author":"Basir","year":"2012","journal-title":"Oman Med J"},{"key":"R22-20250514","first-page":"293","article-title":"Signet ring lymphoma: A potential diagnostic mishap","volume":"26","author":"Krause","year":"2013","journal-title":"Proc (Bayl Univ Med Cent)"},{"key":"R23-20250514","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/cncy.21291","article-title":"Fine-needle aspiration diagnosis of lymphomas with signet ring cell features: Potential pitfalls and solutions","volume":"121","author":"Wang","year":"2013","journal-title":"Cancer Cytopathol"},{"key":"R24-20250514","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.anndiagpath.2016.10.002","article-title":"Signet-ring cell lymphoma: Clinicopathologic, immunohistochemical, and fluorescence in situ hybridization studies of 7 cases","volume":"26","author":"Zhang","year":"2017","journal-title":"Ann Diagn Pathol"},{"key":"R25-20250514","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4103\/0970-9371.197622","article-title":"A rare case of signet ring cell lymphoma: Diagnosis aided by immunofluorescent staining","volume":"34","author":"Gore","year":"2017","journal-title":"J Cytol"}],"container-title":["Journal of Cancer Research and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jcrt.JCRT_676_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:40:41Z","timestamp":1787067641000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jcrt.JCRT_676_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jcrt.jcrt_676_19","relation":{},"ISSN":["0973-1482","1998-4138"],"issn-type":[{"value":"0973-1482","type":"print"},{"value":"1998-4138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"2019-08-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-24","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}