{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:36:38Z","timestamp":1787070998577,"version":"build-2736575974"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Tumor microenvironment plays an important role in cancer progression. Platelets are one of the components of the tumor environment shown to have a role in cancer survival and progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Ninety-six cases of squamous cell carcinoma (SCC) cases of the oral cavity and 96 age\/sex-matched healthy controls were considered for the study. Data regarding platelet count, platelet distribution width (PDW), mean platelet volume (MPV), Platelet-Large Cell Ratio (P-LCR), Plateletcrit (PCT), platelet\/neutrophil ratio (PNR), platelet\/lymphocyte ratio (PLR), and Platelet\/Monocyte Ratio (PNR) from automated hematology analyzer records and clinicopathological data from the Department of Pathology were captured. These data were compared between cases and controls and also with tumor size, tumor grade, lymph node status, and tumour node metastasis (TNM) stage of cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Mean \u00b1 standard deviation for platelet count, PDW, MPV, P-LCR, PCT, PNR, PLR and PMR among cases were 315.03 \u00b1 98.26, 10.94 \u00b1 1.66, 9.91 \u00b1 0.77, 23.52 \u00b1 5.64, 0.31 \u00b1 0.086, 62.55 \u00b1 31.51, 149.34 \u00b1 61.32, and 498.67 \u00b1 194.91, respectively, and among controls were 287.88 \u00b1 74.11, 10.84 \u00b1 1.18, 9.89 \u00b1 0.72, 23.45 \u00b1 4.55, 0.29 \u00b1 0.061, 60.27 \u00b1 21.02, 138.71 \u00b1 49.28, and 497.64 \u00b1 172.28, respectively. The association between means of platelet count, PDW, P-LCR, and PCT among cases and controls were statistically significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.020, 0.006, 0.030, and 0.000, respectively). No statistically significant association was found between means of platelet count, PDW, MPV, P-LCR, PCT, PNR, PLR, and PMR versus tumor size, lymph node status, and tumor grades. The association between the means of PCT\/PMR and TNM Stages I and II were statistically significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.029 and 0.016, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Platelet count, morphology, and functions are altered in oral SCC. Platelet activation plays an important role in oral cancer. PCT and PMR can be used to predict the progress of oral SCC as a cost-effective inflammatory marker.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jcrt.jcrt_786_21","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T03:54:10Z","timestamp":1654833250000},"page":"1036-1041","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Significance of platelet parameters in squamous cell carcinoma of oral cavity \u2013 A case-control study"],"prefix":"10.4103","volume":"18","author":[{"given":"Ankit","family":"Anand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalyani","family":"Raju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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