{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:22:51Z","timestamp":1787847771286,"version":"build-2784847793"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Stereotactic ablative radiotherapy (SABR) is increasingly administered in hepatocellular carcinoma (HCC) treatment. The CyberKnife (CK) system is the most advanced robotic radiosurgery system for delivering SABR. Using three-dimensional multi-angle irradiation, a unique fiducial marker, and a synchronous respiratory tracking system, the off-target caused by respiratory movement is maximally avoided, which achieves favorable dose conformation, and the dose rapidly drops off in the surrounding normal tissue. In a real sense, CK achieves accurate positioning, planning, and irritation. The Chinese expert consensus on CK for HCC was established after discussion.<\/jats:p>","DOI":"10.4103\/jcrt.jcrt_7_25","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T07:00:25Z","timestamp":1779951625000},"page":"215-221","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Expert consensus on robotic radiosurgery system for hepatocellular carcinoma"],"prefix":"10.4103","volume":"22","author":[{"given":"Bin","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Peking University Third Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking University Third Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuping","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Oncology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youke","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Oncology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Oncology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking University Third Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking University Third Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking University Third Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking University Third Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking University Third Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xue","sequence":"additional","affiliation":[{"name":"Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wu","sequence":"additional","affiliation":[{"name":"Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enmin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huojun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Changhai Hospital, Naval Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benhua","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Union Hospital Affiliated to Fujian Medical University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Jilin Provincial Cancer Hospital, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuezhang","family":"Duan","sequence":"additional","affiliation":[{"name":"Radiation Oncology Center, The Fifth Medical Center of PLA General Hospital (Beijing 302 Hospital), No. 100 \u00d7 i Si Huan Middle Road, Fengtai District, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking University Third Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"R1-20260528","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"R2-20260528","first-page":"47","article-title":"Cancer incidence and mortality in China, 2022","volume":"4","author":"Han","year":"2024","journal-title":"J Natl Cancer Cent"},{"key":"R3-20260528","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S0140-6736(22)01200-4","article-title":"Hepatocellular carcinoma","volume":"400","author":"Vogel","year":"2022","journal-title":"Lancet"},{"key":"R4-20260528","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jhep.2021.11.018","article-title":"BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update","volume":"76","author":"Reig","year":"2022","journal-title":"J Hepatol"},{"key":"R5-20260528","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1056\/NEJMra1713263","article-title":"Hepatocellular Carcinoma","volume":"380","author":"Villanueva","year":"2019","journal-title":"N Engl J Med"},{"key":"R6-20260528","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ijrobp.2023.08.015","article-title":"Stereotactic body radiation therapy for hepatocellular carcinoma: Meta-analysis and international stereotactic radiosurgery society practice guidelines","volume":"118","author":"Bae","year":"2024","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R7-20260528","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1200\/JCO.18.02184","article-title":"Neoadjuvant three-dimensional conformal radiotherapy for resectable hepatocellular carcinoma with portal vein tumor thrombus: A randomized, open-label, multicenter controlled study","volume":"37","author":"Wei","year":"2019","journal-title":"J Clin Oncol"},{"key":"R8-20260528","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1001\/jamasurg.2022.4702","article-title":"Phase 2 evaluation of neoadjuvant intensity-modulated radiotherapy in centrally located hepatocellular carcinoma: A nonrandomized controlled trial","volume":"157","author":"Wu","year":"2022","journal-title":"JAMA Surg"},{"key":"R9-20260528","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.jhep.2020.09.026","article-title":"Proton beam radiotherapy vs. radiofrequency ablation for recurrent hepatocellular carcinoma: A randomized phase III trial","volume":"74","author":"Kim","year":"2021","journal-title":"J Hepatol"},{"key":"R10-20260528","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s13014-020-01634-z","article-title":"Clinical impact of Hypofractionated carbon ion radiotherapy on locally advanced hepatocellular carcinoma","volume":"15","author":"Shiba","year":"2020","journal-title":"Radiat Oncol"},{"key":"R11-20260528","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.ijrobp.2023.02.036","article-title":"Repeated carbon-ion radiation therapy for intrahepatic recurrent hepatocellular carcinoma","volume":"116","author":"Tomizawa","year":"2023","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R12-20260528","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jhep.2011.07.012","article-title":"Radioembolization for hepatocellular carcinoma","volume":"56","author":"Sangro","year":"2012","journal-title":"J Hepatol"},{"key":"R13-20260528","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ijrobp.2020.08.046","article-title":"Individualized adaptive radiation therapy allows for safe treatment of hepatocellular carcinoma in patients with Child-Turcotte-Pugh B liver disease","volume":"109","author":"Jackson","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R14-20260528","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.3390\/jcm12103517","article-title":"Local therapies for hepatocellular carcinoma and role of MRI-guided adaptive radiation therapy","volume":"12","author":"Liu","year":"2023","journal-title":"J Clin Med"},{"key":"R15-20260528","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000367767","article-title":"How to improve therapeutic ratio in radiotherapy of HCC","volume":"5","author":"Tsai","year":"2016","journal-title":"Liver Cancer"},{"key":"R16-20260528","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.soc.2023.02.002","article-title":"Advances in radiation therapy for primary liver cancer","volume":"32","author":"Cuneo","year":"2023","journal-title":"Surg Oncol Clin N Am"},{"key":"R17-20260528","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1118\/1.1758351","article-title":"Dosimetric properties of radiophotoluminescent glass rod detector in high-energy photon beams from a linear accelerator and cyber-knife","volume":"31","author":"Arakia","year":"2004","journal-title":"Med Phys"},{"key":"R18-20260528","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1177\/153303461000900502","article-title":"The CyberKnife robotic radiosurgery system in 2010","volume":"9","author":"Kilby","year":"2010","journal-title":"Technol Cancer Res Treat"},{"key":"R19-20260528","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1111\/1754-9485.13309","article-title":"Stereotactic ablative radiotherapy for hepatocellular carcinoma: A systematic review and meta-analysis of local control, survival and toxicity outcomes","volume":"65","author":"Shanker","year":"2021","journal-title":"J Med Imaging Radiat Oncol"},{"key":"R20-20260528","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1111\/jgh.15175","article-title":"Stereotactic radiotherapy for hepatocellular carcinoma: Expanding the multidisciplinary armamentarium","volume":"36","author":"Shanker","year":"2021","journal-title":"J Gastroenterol Hepatol"},{"key":"R21-20260528","doi-asserted-by":"crossref","first-page":"8802","DOI":"10.3390\/curroncol29110692","article-title":"Stereotactic radiotherapy after incomplete transarterial (chemo-) embolization (TAE\\TACE) versus exclusive TAE or TACE for treatment of inoperable HCC: A phase III trial (NCT02323360)","volume":"29","author":"Comito","year":"2022","journal-title":"Curr Oncol"},{"key":"R22-20260528","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ijrobp.2022.09.052","article-title":"Phase 1 randomized trial of stereotactic body radiation therapy followed by nivolumab plus ipilimumab or nivolumab alone in advanced\/unresectable hepatocellular carcinoma","volume":"115","author":"Juloori","year":"2023","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R23-20260528","first-page":"1495","article-title":"Is hepatocellular carcinoma complicated with portal vein tumor thrombosis potentially curable by radiotherapy in the form of stereotactic body radiation therapy?Int J Radiat Biol","volume":"98","author":"Srivastava","year":"2022"},{"key":"R24-20260528","doi-asserted-by":"crossref","first-page":"4088","DOI":"10.1158\/1078-0432.CCR-22-2592","article-title":"Efficacy and safety of stereotactic body radiotherapy combined with camrelizumab and apatinib in patients with hepatocellular carcinoma with portal vein tumor thrombus","volume":"29","author":"Hu","year":"2023","journal-title":"Clin Cancer Res"},{"key":"R25-20260528","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.radonc.2018.12.005","article-title":"Clinical feasibility and efficacy of stereotactic body radiotherapy for hepatocellular carcinoma: A systematic review and meta-analysis of observational studies","volume":"131","author":"Rim","year":"2019","journal-title":"Radiother Oncol"},{"key":"R26-20260528","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ijrobp.2011.11.058","article-title":"Stereotactic body radiation therapy in recurrent hepatocellular carcinoma","volume":"84","author":"Huang","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R27-20260528","doi-asserted-by":"crossref","first-page":"e447","DOI":"10.1016\/j.ijrobp.2011.04.011","article-title":"Stereotactic body radiotherapy for primary hepatocellular carcinoma","volume":"81","author":"Andolino","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R28-20260528","first-page":"644","article-title":"Oxford Centre for Evidence-Based Medicine (OCEBM) Levels of Evidence Working Group","volume":"68","author":"Durieux","year":"2013","journal-title":"The Oxford levels of evidence 2. 2010-10-07 [2024-07-30]. Rev Med Liege"},{"key":"R29-20260528","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13014-021-01778-6","article-title":"Optimal stereotactic body radiotherapy dosage for hepatocellular carcinoma: A multicenter study","volume":"16","author":"Su","year":"2021","journal-title":"Radiat Oncol"},{"key":"R30-20260528","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1118\/1.3438081","article-title":"Stereotactic body radiation therapy: The report of AAPM Task Group 101","volume":"37","author":"Benedict","year":"2010","journal-title":"Med Phys"},{"key":"R31-20260528","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.3390\/curroncol30020190","article-title":"Stereotactic body radiotherapy for hepatocellular carcinoma: A brief overview","volume":"30","author":"Matsuo","year":"2023","journal-title":"Curr Oncol"},{"key":"R32-20260528","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1186\/s12885-016-2512-x","article-title":"Clinical outcomes and prognostic factors of cyberknife stereotactic body radiation therapy for unresectable hepatocellular carcinoma","volume":"16","author":"Que","year":"2016","journal-title":"BMC Cancer"},{"key":"R33-20260528","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.ijrobp.2017.02.095","article-title":"Long-term survival analysis of stereotactic ablative radiotherapy versus liver resection for small hepatocellular carcinoma","volume":"98","author":"Su","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R34-20260528","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1002\/hep.31992","article-title":"Prospective study of stereotactic body radiation therapy for hepatocellular carcinoma on waitlist for liver transplant","volume":"74","author":"Wong","year":"2021","journal-title":"Hepatology"},{"key":"R35-20260528","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jhep.2017.02.022","article-title":"Stereotactic body radiotherapy vs. TACE or RFA as a bridge to transplant in patients with hepatocellular carcinoma. An intention-to-treat analysis","volume":"67","author":"Sapisochin","year":"2017","journal-title":"J Hepatol"},{"key":"R36-20260528","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ijrobp.2019.05.066","article-title":"Comparison of stereotactic body radiation therapy and transarterial chemoembolization for unresectable medium-sized hepatocellular carcinoma","volume":"105","author":"Shen","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R37-20260528","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ijrobp.2023.03.064","article-title":"Transarterial chemoembolization with drug-eluting beads versus stereotactic body radiation therapy for hepatocellular carcinoma: Outcomes from a multicenter, randomized, phase 2 trial (the TRENDY Trial)","volume":"117","author":"Mendez Romero","year":"2023","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R38-20260528","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ijrobp.2022.05.021","article-title":"Combination transarterial chemoembolization and stereotactic body radiation therapy for unresectable single large hepatocellular carcinoma: Results from a prospective phase 2 trial","volume":"114","author":"Buckstein","year":"2022","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R39-20260528","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.ijrobp.2020.07.033","article-title":"A pilot trial evaluating stereotactic body radiation therapy to induce hyperemia in combination with transarterial chemoembolization for hepatocellular carcinoma","volume":"108","author":"Sebastian","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R40-20260528","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.ijrobp.2019.09.006","article-title":"Safety and efficacy of liver stereotactic body radiation therapy for hepatocellular carcinoma after segmental transarterial radioembolization","volume":"105","author":"Hardy-Abeloos","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R41-20260528","doi-asserted-by":"crossref","first-page":"e0268779","DOI":"10.1371\/journal.pone.0268779","article-title":"Stereotactic body radiotherapy plus transcatheter arterial chemoembolization for inoperable hepatocellular carcinoma patients with portal vein tumour thrombus: A meta-analysis","volume":"17","author":"Zhang","year":"2022","journal-title":"PLoS One"},{"key":"R42-20260528","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ijrobp.2012.08.043","article-title":"Hepatocellular carcinoma radiation therapy: Review of evidence and future opportunities","volume":"87","author":"Klein","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Journal of Cancer Research and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jcrt.jcrt_7_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:36:50Z","timestamp":1787845010000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jcrt.jcrt_7_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/jcrt.jcrt_7_25","relation":{},"ISSN":["0973-1482","1998-4138"],"issn-type":[{"value":"0973-1482","type":"print"},{"value":"1998-4138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-01-08","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}