{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:22:26Z","timestamp":1787840546027,"version":"build-2784847793"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    Lumbar spondylolisthesis can cause a significant disability due to back and lower extremity pain. Degenerative spondylolisthesis (DS) and isthmic spondylolisthesis (IS) are the two most common types. DS results from arthritic changes and degenerative disc disease, whereas IS occurs secondary to a pars interarticularis defect. This study compared surgical outcomes between IS and DS. A systematic literature review and meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Twenty studies comprising 3136 patients were included (DS: 1944; IS: 1192). No differences were identified in terms of estimated blood loss (mean difference [MD]: 5.79, 95% confidence interval [CI]: 42.88, 54.46;\n                    <jats:italic toggle=\"yes\">I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 81.7%), length of stay (MD: 0.24, 95% CI: 1.38\u20130.90;\n                    <jats:italic toggle=\"yes\">I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 87.7%), duration of operation (MD: 2.73, 95% CI: 20.61\u201315.16;\n                    <jats:italic toggle=\"yes\">I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 84.7%), reduction of Visual Analog Scale (VAS) for back pain before and after surgery (MD: 0.01, 95% CI: 0.68\u20130.65;\n                    <jats:italic toggle=\"yes\">I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 87.5%), reduction in Oswestry Disability Index before and after surgery (MD: 1.37, 95% CI: 2.39\u20135.12;\n                    <jats:italic toggle=\"yes\">I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 75.5%), return to operating room for any reason (odds ratio [OR]: 1.01, 95% CI: 0.48\u20132.15;\n                    <jats:italic toggle=\"yes\">I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 0%), successful fusion at the last follow-up (OR: 0.68, 95% CI: 0.26\u20131.77;\n                    <jats:italic toggle=\"yes\">I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 60.5%), adjacent segment disease during follow-up (OR: 0.45, 95% CI: 0.18\u20131.13;\n                    <jats:italic toggle=\"yes\">I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 0%), and subjective unsatisfactory outcome (OR: 1.53; 95% CI: 0.99\u20132.35;\n                    <jats:italic toggle=\"yes\">I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 0%). IS was associated with significantly higher odds for reporting subjective unsatisfactory outcome compared to DS (OR: 1.56; 95% CI: 1.00\u20132.43,\n                    <jats:italic toggle=\"yes\">I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    : 0%) in the subgroup analysis of posterior lumbar interbody fusion\/transforaminal lumbar interbody fusion. DS showed greater VAS back pain reduction than IS with posterolateral fusion alone (MD: -1.06, 95% CI: -1.90\u20130.22,\n                    <jats:italic toggle=\"yes\">I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    :0%). Surgical outcomes are largely comparable between IS and DS, though etiology-specific differences in patient-reported outcomes may depend on fusion technique.\n                  <\/jats:p>","DOI":"10.4103\/jcvjs.jcvjs_10_26","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T13:00:32Z","timestamp":1773838832000},"page":"108-117","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of lumbar fusion surgery in isthmic versus degenerative spondylolisthesis: A systematic review and meta-analysis"],"prefix":"10.4103","volume":"17","author":[{"given":"Pavlos","family":"Texakalidis","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Northwestern Memorial Hospital, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros","family":"Matsoukas","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantine L.","family":"Karras","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Northwestern Memorial Hospital, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher S.","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Northwestern Memorial Hospital, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najib El","family":"Tecle","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Northwestern Memorial Hospital, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler R.","family":"Koski","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Northwestern Memorial Hospital, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader S.","family":"Dahdaleh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Northwestern Memorial Hospital, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"R1-20260319","doi-asserted-by":"crossref","first-page":"98","DOI":"10.22603\/ssrr.2017-0007","article-title":"Genetic background of degenerative disc disease in the lumbar spine","volume":"2","author":"Kawaguchi","year":"2018","journal-title":"Spine Surg Relat Res"},{"key":"R2-20260319","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1007\/s00586-015-4177-6","article-title":"Surgery for adult spondylolisthesis: A systematic review of the evidence","volume":"25","author":"Schulte","year":"2016","journal-title":"Eur Spine J"},{"key":"R3-20260319","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/00003086-197606000-00003","article-title":"Classification of spondylolisis and spondylolisthesis","volume":"117","author":"Wiltse","year":"1976","journal-title":"Clin Orthop Relat Res"},{"key":"R4-20260319","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1055\/s-0032-1307257","article-title":"High-grade adult isthmic L5-s1 spondylolisthesis: A report of intraoperative slip progression treated with surgical reduction and posterior instrumented fusion","volume":"2","author":"Mikhael","year":"2012","journal-title":"Global Spine J"},{"key":"R5-20260319","first-page":"S30","article-title":"A critical analysis of the literature regarding surgical approach and outcome for adult low-grade isthmic spondylolisthesis","volume":"18","author":"Kwon","year":"2005","journal-title":"Clin Spine Surg"},{"key":"R6-20260319","doi-asserted-by":"crossref","first-page":"83","DOI":"10.21037\/jss-22-24","article-title":"Outcomes of surgical intervention for degenerative lumbar spondylolisthesis: A comparative analysis of different surgical fixation techniques","volume":"9","author":"Jadhakhan","year":"2023","journal-title":"J Spine Surg"},{"key":"R7-20260319","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1007\/s00586-013-3144-3","article-title":"Surgery in lumbar degenerative spondylolisthesis: Indications, outcomes and complications. 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