{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:32:44Z","timestamp":1787761964235,"version":"build-2784847793"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Various minimally invasive surgeries were proposed for the management of herniated lumbar intervertebral disc. However, to choose optimal treatment modality to maximize patient benefit is a clinical challenge for the treatment givers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The objective was to study the role of ozone disc nucleolysis in the management of herniated lumbar intervertebral disc by retrospective analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of patients of lumbar disc herniation treated by ozone disc nucleolysis during May 2007\u2013May 2021. There were total of 2089 patients with 58% of males and 42% of females. The age ranged from 18 to 88 years. Outcome was measured on the Visual Analog Scale (VAS) and the Oswestry Disability Index (ODI) along with modified MacNab method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean baseline VAS score was 7.73, which became 3.07 at 1 month, 1.44 at 3 months, 1.42 at 6 months, and 1.36 at 1 year. Similarly, the mean ODI index was 35.92 at baseline, which improved to 9.17 at 1 month, 6.14 at 3 months, 6.10 at 6 months, and 6.09 at 1 year. VAS score and ODI analysis was found to be statistically significant with\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05. Modified MacNab criterion showed successful treatment outcome in 85.6% with excellent recovery in 1161 (55.58%), good recovery in 423 (20.25%), and fair recovery in 204 (9.77%). Mediocre or no recovery was seen in the remaining 301 patients amounting to a 14.40% failure rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This retrospective analysis confirms that ozone disc nucleolysis is an optimally effective and least invasive treatment option for herniated lumbar intervertebral disc with a significant reduction in disability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jcvjs.jcvjs_141_22","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T02:36:05Z","timestamp":1678674965000},"page":"16-23","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Ozone disc nucleolysis in the management of herniated lumbar intervertebral disc"],"prefix":"10.4103","volume":"14","author":[{"given":"Sharad Balasaheb","family":"Ghatge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit Pannalal","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmal","family":"Surya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Sankhala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetan Jagjivandas","family":"Unadkat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulam M.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhaval B.","family":"Modi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20240904","doi-asserted-by":"crossref","first-page":"299","DOI":"10.21037\/atm.2020.02.175","article-title":"Global low back pain prevalence and years lived with disability from 1990 to 2017: Estimates from the Global Burden of Disease Study 2017","volume":"8","author":"Wu","year":"2020","journal-title":"Ann Transl Med"},{"key":"R2-4-20240904","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1097\/BRS.0b013e318133fad8","article-title":"Back pain in the German adult population: Prevalence, severity, and sociodemographic correlates in a multiregional survey","volume":"32","author":"Schmidt","year":"2007","journal-title":"Spine (Phila Pa 1976"},{"key":"R3-4-20240904","first-page":"996","article-title":"Minimally invasive oxygen-ozone therapy for lumbar disk herniation","volume":"24","author":"Andreula","year":"2003","journal-title":"AJNR Am J Neuroradiol"},{"key":"R4-4-20240904","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0150-9861(04)96989-1","article-title":"Treatment of herniated lumbar disc by intradiscal and intraforaminal oxygen-ozone (O2-O3) injection","volume":"31","author":"Muto","year":"2004","journal-title":"J Neuroradiol"},{"key":"R5-4-20240904","first-page":"996","article-title":"2)-O. versus periradicular steroidal infiltrations in lower back pain: Randomized controlled study","volume":"26","author":"Bonetti","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"R6-4-20240904","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1526-4637.2011.01089.x","article-title":"Failed back surgery syndrome","volume":"12","author":"Chan","year":"2011","journal-title":"Pain Med"},{"key":"R7-4-20240904","first-page":"271","article-title":"The Oswestry low back pain disability questionnaire","volume":"66","author":"Fairbank","year":"1980","journal-title":"Physiotherapy"},{"key":"R8-4-20240904","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/ar.1092200402","article-title":"Human intervertebral disc: Structure and function","volume":"220","author":"Humzah","year":"1988","journal-title":"Anat Rec"},{"key":"R9-4-20240904","doi-asserted-by":"crossref","first-page":"E93","DOI":"10.1097\/00007632-200103010-00006","article-title":"Nomenclature and classification of lumbar disc pathology. 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