{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:33:20Z","timestamp":1787758400812,"version":"build-2784847793"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Association of genetic polymorphisms in paired box 1 (\n                      <jats:italic toggle=\"yes\">PAX-1<\/jats:italic>\n                      ) gene can influence the development of adolescent idiopathic scoliosis (AIS). PAX-1 is mainly expressed in the region of the vertebral bodies and intervertebral discs, being important for the proper formation of spinal structures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>\n                      The objective of this study was to evaluate the association of polymorphisms in\n                      <jats:italic toggle=\"yes\">PAX-1<\/jats:italic>\n                      gene with the susceptibility of AIS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings and Design:<\/jats:title>\n                    <jats:p>This was an analytical observational case\u2013control study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Samples of 59 AIS indicated for surgical treatment, and 119 controls, without spinal disease were genotyped for\n                      <jats:italic toggle=\"yes\">PAX-1<\/jats:italic>\n                      rs6137473 and rs169311 polymorphisms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis:<\/jats:title>\n                    <jats:p>The association of the polymorphisms with AIS was evaluated by a multivariable logistic regression model, using odds ratios (OR) and 95% confidence intervals (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      According to Lenke's classification, 89.8% had Type I and 10.2% II curves. The mean value of the Cobb angle of the proximal thoracic curve was 30.8\u00b0, 58.7\u00b0 thoracic, and 30.4\u00b0 for the lumbar and on the bending films 14.6\u00b0, 40.7\u00b0, and 11\u00b0, respectively. Among the AIS group, there was a predominance of females (8.8:1). The\n                      <jats:italic toggle=\"yes\">PAX-1<\/jats:italic>\n                      rs169311 and rs6137473 polymorphisms were positively associated with developing the AIS (OR = 1.98; 95% CI = 1.2\u20133.3 and OR = 3.16; 95% CI = 1.4\u20137.3, respectively). The rs6137473 polymorphism was associated with the lumbar modifier B and C compared to A (OR = 2.52; 95% CI = 1.1\u20135.8).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">PAX-1<\/jats:italic>\n                      polymorphisms were associated with an increased risk of developing the AIS and with curve severity and can be used as a biomarker to map the risk of developing surgical-grade AIS, guiding the treatment of patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jcvjs.jcvjs_54_22","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T05:18:30Z","timestamp":1663046310000},"page":"318-324","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Polymorphisms in paired box 1 gene were associated with susceptibility of adolescent idiopathic scoliosis"],"prefix":"10.4103","volume":"13","author":[{"given":"Ant\u00f4nio Eul\u00e1lio","family":"Pedrosa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Borges Laurindo de","family":"Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica Vilarinho","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Antonio Matheus","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helton Luiz Aparecido","family":"Defino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamila Alessandra","family":"Perini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-12-20240904","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13013-017-0145-8","article-title":"2016 SOSORT guidelines: Orthopaedic and rehabilitation treatment of idiopathic scoliosis during growth","volume":"13","author":"Negrini","year":"2018","journal-title":"Scoliosis Spinal Disord"},{"key":"R2-12-20240904","first-page":"834","article-title":"Clinical practice","volume":"368","author":"Hresko","year":"2013","journal-title":"Idiopathic scoliosis in adolescents. 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