{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:04:09Z","timestamp":1787169849904,"version":"build-2736575974"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Subarachnoid hemorrhage (SAH) is a serious pathology with a high death and morbidity rate. There can be a relationship between hydromyelia and hydrocephalus following SAH; however, this subject has not been well investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Twenty-four rabbits (3 \u00b1 0.4 years old; 4.4 \u00b1 0.5 kg) were used in this study. Five of them were used as the control, and five of them as the SHAM group. The remaining animals (n = 14) had been used as the study group. The central canal volume values at the C1-C2 levels, ependymal cells, numbers of central canal surfaces, and Evans index values of the lateral ventricles were assessed and compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Choroid plexus edema and increased water vesicles were observed in animals with central canal dilatation. The Evans index of the brain ventricles was 0.33 \u00b1 0.05, the mean volume of the central canal was 1.431 \u00b1 0.043 mm\n                      <jats:sup>3<\/jats:sup>\n                      , and ependymal cells density was 5.420 \u00b1 879\/mm\n                      <jats:sup>2<\/jats:sup>\n                      in the control group animals (n = 5); 0.35 \u00b1 0.17, 1.190 \u00b1 0.114 mm\n                      <jats:sup>3<\/jats:sup>\n                      , and 4.135 \u00b1 612\/mm\n                      <jats:sup>2<\/jats:sup>\n                      in the SHAM group animals (n = 5); and 0.44 \u00b1 0.68, 1.814 \u00b1 0.139 mm\n                      <jats:sup>3<\/jats:sup>\n                      , and 2.512 \u00b1 11\/mm\n                      <jats:sup>2<\/jats:sup>\n                      in the study group (n = 14). The relationship between the Evans index values, the central canal volumes, and degenerated ependymal cell densities was statistically significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study showed that hydromyelia occurs following SAH-induced experimental hydrocephalus. Desquamation of ependymal cells and increased cerebrospinal fluid secretion may be responsible factors in the development of hydromyelia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jcvjs.jcvjs_67_23","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T05:32:07Z","timestamp":1695015127000},"page":"253-258","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["New histopathological evidence for the relationship between hydromyelia and hydrocephalus following subarachnoid hemorrhage: An experimental study"],"prefix":"10.4103","volume":"14","author":[{"given":"Ahmet","family":"Yardim","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Medical Faculty, Aksaray University, Aksaray, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayhan","family":"Kanat","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, 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