{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:14:18Z","timestamp":1791897258906,"version":"4.3.4"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hemangioblastomas (HBs) are rare lesions accounting for 1%\u20135% of all spinal cord tumors, and are mostly associated with Von Hippel-Lindau (VHL) syndrome. Localization in the cauda equina is uncommon.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>In this manuscript, we aimed to describe a rare case of sporadic intradural extramedullary HB of the cauda equina and present a literature review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Mathods:<\/jats:title>\n                    <jats:p>A systematic research was performed on PubMed, MEDLINE, and Google Scholar, using the keywords \u201cspinal HB\u201d and \u201ccauda equina tumors.\u201d The previous literature is integrated by the description of the present case. A 49-year-old female presented in August 2020 to our institution with a magnetic resonance imaging (MRI) which showed an intradural mass at L1\/2 level and angiography that showing a nidus of serpiginous vessels inside the lesion. Symptoms were right sciatica and paresthesia in right L5 radicular dermatome for more than 3 months. Neurological examination revealed claudicatio spinalis and hypoesthesia on right L5 dermatome and weakness of right anterior tibialis muscle. Microsurgical en bloc resection of lesion was performed with adjuvant neurophysiological intraoperative monitoring. The histological examination provided the diagnosis of HB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>After surgery, symptoms and neurological impairment gradually improved. Postoperative MRI showed no residual tumor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Although intradural extramedullary HB of the cauda equina without VHL syndrome is a rare pathological entity, this diagnosis must be taken in consideration when a mass affects cauda equina. Preoperative embolization is an option to minimize intraoperative bleeding. Radiosurgery seems to prevent recurrences when the tumor is not completely excised. A complete surgical removal of the lesion is usually possible and it leads to a low likelihood of recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jcvjs.jcvjs_87_22","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T05:18:30Z","timestamp":1663046310000},"page":"265-270","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Sporadic hemangioblastoma of cauda equina"],"prefix":"10.4103","volume":"13","author":[{"given":"Salvatore","family":"D' Oria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Giraldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Andres Alvarado","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Murrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"D' Angelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bipin","family":"Chaurasia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20240904","first-page":"58","article-title":"Isolated hemangioblastoma of the filum terminale","volume":"45","author":"Farneti","year":"2001","journal-title":"Case report. J Neurosurg Sci"},{"key":"R2-6-20240904","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S0090-3019(03)00399-9","article-title":"Proximal nerve root spinal hemangioblastomas: Presentation of three cases, MR appearance, and literature review","volume":"61","author":"Escott","year":"2004","journal-title":"Surg Neurol"},{"key":"R3-6-20240904","first-page":"435","article-title":"Hemangioblastoma of the spinal cord","volume":"33","author":"Browne","year":"1976","journal-title":"Review and report of five cases. Arch Neurol"},{"key":"R4-6-20240904","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11060-020-03506-8","article-title":"Role of VHL-JAK-STAT signaling pathway in central nervous system hemangioblastoma associated with von Hippel-Lindau disease","volume":"148","author":"Kanno","year":"2020","journal-title":"J Neurooncol"},{"key":"R5-6-20240904","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000441147","article-title":"Incidence and prognosis of spinal hemangioblastoma: A surveillance epidemiology and end results study","volume":"46","author":"Westwick","year":"2016","journal-title":"Neuroepidemiology"},{"key":"R6-6-20240904","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0025-6196(11)65031-3","article-title":"Von Hippel-Lindau disease","volume":"75","author":"Couch","year":"2000","journal-title":"In Mayo Clin Proc Elsevier"},{"key":"R7-6-20240904","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s11060-019-03189-w","article-title":"Sporadic and von-Hippel Lindau disease-associated spinal hemangioblastomas: Institutional experience on their similarities and differences","volume":"143","author":"Yousef","year":"2019","journal-title":"J Neurooncol"},{"key":"R8-6-20240904","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3171\/2017.3.SPINE1622","article-title":"Intraosseous hemangioblastoma of the cervical spine: Case report","volume":"27","author":"Li","year":"2017","journal-title":"J Neurosurg Spine"},{"key":"R9-6-20240904","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3171\/jns.2003.98.1.0082","article-title":"The natural history of hemangioblastomas of the central nervous system in patients with von Hippel-Lindau disease","volume":"98","author":"Wanebo","year":"2003","journal-title":"J Neurosurg"},{"key":"R10-6-20240904","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/ons\/opx019","article-title":"Functional outcome after resection of von Hippel-Lindau disease-associated cauda equina hemangioblastomas: An observational cohort study","volume":"13","author":"Mehta","year":"2017","journal-title":"Oper Neurosurg (Hagerstown"},{"key":"R11-6-20240904","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2214\/ajr.174.2.1740377","article-title":"MR imaging of spinal hemangioblastoma","volume":"174","author":"Baker","year":"2000","journal-title":"AJR Am J Roentgenol"},{"key":"R12-6-20240904","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.wneu.2017.10.104","article-title":"Sporadic intradural extramedullary hemangioblastoma of the cauda equina: Case report and literature review","volume":"109","author":"Blaty","year":"2018","journal-title":"World Neurosurg"},{"key":"R13-6-20240904","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3390\/surgeries2030030","article-title":"Surgical approach for spinal tumors: Our experience in combined military hospital dhaka","volume":"2","author":"Islam","year":"2021","journal-title":"Surgeries"},{"key":"R14-6-20240904","doi-asserted-by":"crossref","first-page":"405","DOI":"10.25259\/SNI_579_2020","article-title":"Diagnosis and treatment of noncommunicating extradural spinal thoracolumbar arachnoid cyst","volume":"11","author":"Khan","year":"2020","journal-title":"Surg Neurol Int"},{"key":"R15-6-20240904","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s007010070063","article-title":"Extramedullary hemangioblastoma of the conus medullaris","volume":"142","author":"Brisman","year":"2000","journal-title":"Acta Neurochir (Wien"},{"key":"R16-6-20240904","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.3390\/ijerph19031719","article-title":"Virtual reality in neurosurgery: Beyond neurosurgical planning","volume":"19","author":"Mishra","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"R17-6-20240904","first-page":"84","article-title":"Focused ultrasound in neuroscience","volume":"11","author":"Giammalva","year":"2021","journal-title":"State of the art and future perspectives. Brain Sci"},{"key":"R18-6-20240904","first-page":"55","article-title":"Hemangioblastomas of the central nervous system in von Hippel-Lindau syndrome and sporadic disease","volume":"48","author":"Conway","year":"2001","journal-title":"Neurosurgery"},{"key":"R19-6-20240904","first-page":"145","article-title":"Does hemangioblastoma exist outside von Hippel-Lindau disease?","volume":"40","author":"Richard","year":"1994","journal-title":"Neurochirurgie"},{"key":"R20-6-20240904","first-page":"160","article-title":"Hemangioblastoma of the L-5 nerve root","volume":"90","author":"Chazono","year":"1999","journal-title":"Case illustration. J Neurosurg"},{"key":"R21-6-20240904","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.compmedimag.2007.08.008","article-title":"MRI of hemangioblastoma in the conus medullaris","volume":"32","author":"Chen","year":"2008","journal-title":"Comput Med Imaging Graph"},{"key":"R22-6-20240904","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1590\/S0004-282X2003000300024","article-title":"Cauda equina hemangioblastoma: Case report","volume":"61","author":"da Costa","year":"2003","journal-title":"Arq Neuropsiquiatr"},{"key":"R23-6-20240904","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s13760-020-01420-4","article-title":"Spinal hemangioblastoma: Surgical procedures, outcomes and review of the literature","volume":"121","author":"Wang","year":"2021","journal-title":"Acta Neurol Belg"},{"key":"R24-6-20240904","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2176\/nmc.52.659","article-title":"Intra-extradural dumbbell-shaped hemangioblastoma manifesting as subarachnoid hemorrhage in the cauda equina","volume":"52","author":"Nishimura","year":"2012","journal-title":"Neurol Med Chir (Tokyo"},{"key":"R25-6-20240904","first-page":"206","article-title":"MR findings in spinal hemangioblastoma: Correlation with symptoms and with angiographic and surgical findings","volume":"22","author":"Chu","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"R26-6-20240904","first-page":"192","article-title":"Treatment of spinal vascular malformations: an integrated approach","volume":"52","author":"Gonzalez","year":"2005","journal-title":"Clinical Neurosurgery"},{"key":"R27-6-20240904","doi-asserted-by":"crossref","first-page":"E969","DOI":"10.1097\/BRS.0b013e3181b8e4f4","article-title":"A rare case of extramedullary-intradural hemangioblastoma in the thoracic spine","volume":"34","author":"Taniguchi","year":"2009","journal-title":"Spine (Phila Pa 1976"},{"key":"R28-6-20240904","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s11060-009-9861-0","article-title":"Results of microsurgical treatment of medulla oblongata and spinal cord hemangioblastomas: A comparison of two distinct clinical patient groups","volume":"93","author":"Parker","year":"2009","journal-title":"J Neurooncol"},{"key":"R29-6-20240904","doi-asserted-by":"crossref","first-page":"560","DOI":"10.2176\/nmc.50.560","article-title":"Comparative analysis of spinal hemangioblastomas in sporadic disease and von Hippel-Lindau syndrome","volume":"50","author":"Takai","year":"2010","journal-title":"Neurol Med Chir (Tokyo"},{"key":"R30-6-20240904","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3340\/jkns.2012.52.3.221","article-title":"Surgical outcome of spinal cord hemangioblastomas","volume":"52","author":"Park","year":"2012","journal-title":"J Korean Neurosurg Soc"},{"key":"R31-6-20240904","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1023\/A:1021297622944","article-title":"Spinal cord hemangioblastoma: Surgical strategy and clinical outcome","volume":"61","author":"Lee","year":"2003","journal-title":"J Neurooncol"},{"key":"R32-6-20240904","first-page":"321","article-title":"Surgical management of isolated hemangioblastomas of the spinal cord","volume":"49","author":"Roonprapunt","year":"2001","journal-title":"Neurosurgery"},{"key":"R33-6-20240904","first-page":"936","article-title":"Hemangioblastomas of the lower spinal region: Report of four cases with preoperative embolization and review of the literature","volume":"26","author":"Biondi","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"R34-6-20240904","first-page":"525","article-title":"Preoperative endovascular embolization of craniospinal hemangioblastomas","volume":"17","author":"Eskridge","year":"1996","journal-title":"AJNR Am J Neuroradiol"},{"key":"R35-6-20240904","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11060-019-03213-z","article-title":"Growth rate and fate of untreated hemangioblastomas: Clinical assessment of the experience of a single institution","volume":"144","author":"Byun","year":"2019","journal-title":"J Neurooncol"},{"key":"R36-6-20240904","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s11060-019-03118-x","article-title":"Gamma knife stereotactic radiosurgery favorably changes the clinical course of hemangioblastoma growth in von Hippel-Lindau and sporadic patients","volume":"142","author":"Liebenow","year":"2019","journal-title":"J Neurooncol"},{"key":"R37-6-20240904","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1023\/B:NEON.0000041889.71136.62","article-title":"Spinal cord and intradural-extraparenchymal spinal tumors: Current best care practices and strategies","volume":"69","author":"Parsa","year":"2004","journal-title":"J Neurooncol"},{"key":"R38-6-20240904","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0303-8467(85)90070-8","article-title":"Hemangioblastoma of the cauda equina","volume":"87","author":"Wolbers","year":"1985","journal-title":"Clin Neurol Neurosurg"}],"container-title":["Journal of Craniovertebral Junction and Spine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jcvjs.jcvjs_87_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:12:55Z","timestamp":1787757175000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jcvjs.jcvjs_87_22"}},"subtitle":["A case report and brief literature review"],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jcvjs.jcvjs_87_22","relation":{},"ISSN":["0974-8237"],"issn-type":[{"value":"0974-8237","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]}}}