{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:23:39Z","timestamp":1787844219636,"version":"build-2784847793"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"\n BACKGROUND:<\/jats:title>\n Diagnostic dilemma arises when patients with clinical suspicion of COVID-19 disease having moderate-to-severe respiratory symptoms yield negative result for COVID-19 in reverse transcription polymerase chain reaction (RT-PCR). This study evaluated the clinical, laboratory and HRCT thorax findings among RT-PCR-negative COVID-19 suspects with moderate-to-severe disease.<\/jats:p>\n <\/jats:sec>\n \n MATERIALS AND METHODS:<\/jats:title>\n A hospital-based retrospective observational study was conducted between July 2021 to December 2021, among 60 moderate and severe symptomatic COVID-19 suspects admitted in the severe acute respiratory illness (SARI) ward and intensive care unit (ICU), who were negative for COVID-19 in RT-PCR. Data were abstracted from the medical records section of the hospital using a predesigned data abstraction form and presented by descriptive statistics.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n Mean age of study participants was 55.5 years (SD 14.1 years), and majority were males (\n n<\/jats:italic>\n = 43, 71.7%). Common presenting symptoms were fever (\n n<\/jats:italic>\n = 60, 100%), dyspnea (\n n<\/jats:italic>\n = 57, 95%), and cough (\n n<\/jats:italic>\n = 54, 90%). The common laboratory findings were rise of C-reactive protein (\n n<\/jats:italic>\n = 60, 100%), NLR (\n n<\/jats:italic>\n = 49, 81.7%), d-dimer (\n n<\/jats:italic>\n = 47, 78.3%), ferritin (\n n<\/jats:italic>\n = 46, 76.7%), and LDH (\n n<\/jats:italic>\n = 40, 66.7%). HRCT scan of thorax revealed ground glass opacities with or without consolidations located bilaterally with diffuse or peripheral distribution, interlobar septal thickening (\n n<\/jats:italic>\n = 43, 74.1%), vascular thickening (\n n<\/jats:italic>\n = 35, \u226558.3%), and sub-pleural lines (\n n<\/jats:italic>\n = 32, 53.3%). Median CT-SS value was 15 (IQR 11\u201319), and majority (\n n<\/jats:italic>\n = 56, 93.3%) belonged to CO-RADS \u22654.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n Diagnosis of COVID-19 can be presumed in RT-PCR-negative suspected COVID-19 patients with moderate-to-severe disease, with marked rise of inflammatory markers and HRCT revealing typical findings of COVID-19 pneumonia.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jehp.jehp_287_22","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T11:41:41Z","timestamp":1667302901000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Clinical, laboratory and high-resolution computed tomography (HRCT) thorax profile of reverse transcription polymerase chain reaction (RT-PCR) negative COVID-19 suspects with moderate to severe disease"],"prefix":"10.4103","volume":"11","author":[{"given":"Arnab","family":"Banerjee","sequence":"first","affiliation":[{"name":"Department of General Medicine, Deben Mahata Government Medical College and Hospital, Purulia, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Bankura Sammilani Medical College and Hospital, Bankura, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjita","family":"Santra","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Deben Mahata Government Medical College and Hospital, Purulia, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuran","family":"Bhadury","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Deben Mahata Government Medical College and Hospital, Purulia, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirshendu","family":"Chaudhuri","sequence":"additional","affiliation":[{"name":"Department of Public Health, Institute of Public Health, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"R1-20260529","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41563-020-00906-z","article-title":"Diagnostics for SARS-CoV-2 infections","volume":"20","author":"Kevadiya","year":"2021","journal-title":"Nat Mater"},{"key":"R2-20260529","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1136\/thoraxjnl-2020-214916","article-title":"Managing high clinical suspicion COVID-19 inpatients with negative RT-PCR: A pragmatic and limited role for thoracic 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