{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:29:55Z","timestamp":1787840995157,"version":"build-2784847793"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>INTRODUCTION:<\/jats:title>\n                    <jats:p>Hemophagocytic lymphohistiocytosis (HLH) is caused by overactivation of immune system. Gene mutations, infections, malignant, and autoimmune trigger the development of the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>Clinical data and peripheral blood samples of 21 patients suspected of HLH were collected in Shiraz Medical Centers 2017\u20132018. Peripheral blood samples were analyzed for soluble interleukin-2 receptor alpha (sIL2R\u03b1) marker (sCD25), and the results were compared with 36 normal controls as well as comparison with clinical findings and other laboratory parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Twenty-one patients (11 males and 10 females) with an average age of 5.2 were investigated. In this study, peripheral blood samples were taken from 16 newly diagnosed patients before treatment, and five were posttreatment blood samples. The mean sIL2R\u03b1 level before treatment in 16 patients was 9023 pg\/ml. The mean peripheral blood sample of the 36 controls was 3025 pg\/ml. The mean of the five posttreatment samples was 4198 pg\/ml. Significant difference between pretreatment and the control group was observed. However, no significant difference was detected between after treatment samples and the control group. By comparing the sIL2R\u03b1 levels between patients with increased aspartate aminotransaminase (AST) and patients with normal AST level, there was a significant difference in the amount of IL2R\u03b1 level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>This study highlights the importance of IL2R\u03b1 marker in the diagnosis and follow-up, during treatment and suppression. Furthermore, a significant difference with respect to AST level requires further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jehp.jehp_579_19","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T10:58:09Z","timestamp":1713869889000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Association of soluble interleukin-2 receptor alpha with laboratory parameters and clinical findings of hemophagocytic lymphohistiocytosis patients: The first report from South of Iran"],"prefix":"10.4103","volume":"9","author":[{"given":"Mansoureh","family":"Shokripour","sequence":"first","affiliation":[{"name":"Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"},{"name":"Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maral","family":"Mokhtari","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Samizadeh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,2,28]]},"reference":[{"key":"R1-20260528","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.jpeds.2013.06.053","article-title":"Hemophagocytic lymphohistiocytosis: Advances in pathophysiology, diagnosis, and treatment","volume":"163","author":"Chandrakasan","year":"2013","journal-title":"J Pediatr"},{"key":"R2-20260528","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.3109\/10428194.2011.566394","article-title":"Significance of soluble interleukin-2 receptor in patients with hemophagocytic lymphohistiocytosis","volume":"52","author":"Zhang","year":"2011","journal-title":"Leuk Lymphoma"},{"key":"R3-20260528","first-page":"333","article-title":"Bone marrow and karyotype findings of patients with pancytopenia in Southern Iran","volume":"39","author":"Safaei","year":"2014","journal-title":"Iran J Med Sci"},{"key":"R4-20260528","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/pbc.21039","article-title":"HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis","volume":"48","author":"Henter","year":"2007","journal-title":"Pediatr Blood Cancer"},{"key":"R5-20260528","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.amjmed.2014.04.034","article-title":"Reactive hemophagocytic syndrome in adults: A retrospective analysis of 162 patients","volume":"127","author":"Rivi\u00e8re","year":"2014","journal-title":"Am J Med"},{"key":"R6-20260528","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1182\/blood-2016-01-690636","article-title":"Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages","volume":"127","author":"Emile","year":"2016","journal-title":"Blood"},{"key":"R7-20260528","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13052-016-0262-7","article-title":"Comparison of Th1\/Th2 cytokine profiles between primary and secondary haemophagocytic lymphohistiocytosis","volume":"42","author":"Chen","year":"2016","journal-title":"Ital J Pediatr"},{"key":"R8-20260528","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1002\/art.38690","article-title":"Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome","volume":"66","author":"Fardet","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"R9-20260528","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1182\/blood.V73.8.2128.2128","article-title":"Elevated soluble interleukin-2 receptor in childhood hemophagocytic histiocytic syndromes","volume":"73","author":"Komp","year":"1989","journal-title":"Blood"},{"key":"R10-20260528","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fimmu.2013.00072","article-title":"Elevated granzyme b in cytotoxic lymphocytes is a signature of immune activation in hemophagocytic lymphohistiocytosis","volume":"4","author":"Mellor-Heineke","year":"2013","journal-title":"Front Immunol"},{"key":"R11-20260528","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.4238\/2015.May.18.21","article-title":"Pre-B-cell colony-enhancing factor is markedly elevated in childhood hemophagocytic lymphohistiocytosis","volume":"14","author":"Gao","year":"2015","journal-title":"Genet Mol Res"},{"key":"R12-20260528","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1182\/bloodadvances.2017012310","article-title":"Soluble interleukin-2 receptor is a sensitive diagnostic test in adult HLH","volume":"1","author":"Hayden","year":"2017","journal-title":"Blood Adv"},{"issue":"Suppl 1","key":"R13-20260528","first-page":"4939","article-title":"Natural-killer cell cytotoxicity and interleukin-2R as a relevant marker for diagnosis of secondary hemophagocytic lymphohistiocytosis in adult patients: The results of prospective Phase II observational study","volume":"132","author":"Yoon","year":"2018","journal-title":"Am Soc Hematology"},{"key":"R14-20260528","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3109\/10428199109107916","article-title":"Serum levels of interferon-gamma, cytotoxic factor and soluble interleukin-2 receptor in childhood hemophagocytic syndromes","volume":"3","author":"Imashuku","year":"1991","journal-title":"Leuk Lymphoma"},{"key":"R15-20260528","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.1182\/blood.V86.12.4706.bloodjournal86124706","article-title":"Soluble interleukin-2 receptor: A useful prognostic factor for patients with hemophagocytic lymphohistiocytosis","volume":"86","author":"Imashuku","year":"1995","journal-title":"Blood"},{"key":"R16-20260528","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1002\/art.22416","article-title":"The diagnostic significance of soluble CD163 and soluble interleukin-2 receptor alpha-chain in macrophage activation syndrome and untreated new-onset systemic juvenile idiopathic arthritis","volume":"56","author":"Bleesing","year":"2007","journal-title":"Arthritis Rheum"},{"key":"R17-20260528","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1093\/ajcp\/aqw076","article-title":"Performances of the H-score for diagnosis of hemophagocytic lymphohistiocytosis in adult and pediatric patients","volume":"145","author":"Debaugnies","year":"2016","journal-title":"Am J Clin Pathol"},{"key":"R18-20260528","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1097\/INF.0000000000000685","article-title":"Hemophagocytic lymphohistiocytosis in children with visceral leishmaniasis","volume":"34","author":"Bl\u00e1zquez-Gamero","year":"2015","journal-title":"Pediatr Infect Dis J"},{"key":"R19-20260528","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1177\/0885066613517076","article-title":"hemophagocytic syndrome and critical illness: New insights into diagnosis and management","volume":"30","author":"Tothova","year":"2015","journal-title":"J Intensive Care Med"},{"key":"R20-20260528","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/bjh.13461","article-title":"Laboratory parameters identify familial haemophagocytic lymphohistiocytosis from other forms of paediatric haemophagocytosis","volume":"170","author":"Yasumi","year":"2015","journal-title":"Br J Haematol"}],"container-title":["Journal of Education and Health Promotion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jehp.jehp_579_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:39:05Z","timestamp":1787837945000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jehp.jehp_579_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":20,"URL":"https:\/\/doi.org\/10.4103\/jehp.jehp_579_19","relation":{},"ISSN":["2277-9531","2319-6440"],"issn-type":[{"value":"2277-9531","type":"print"},{"value":"2319-6440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2019-10-03","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-25","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}