{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:27:35Z","timestamp":1786728455775,"version":"build-2736575974"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Preeclampsia remains a major cause of maternal morbidity and mortality, characterized by hypertension and signs of organ dysfunction, including thrombocytopenia. Platelet indices such as mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), and platelet-large cell ratio (P-LCR) are emerging as potential biomarkers for preeclampsia severity and progression. To assess the association between platelet indices and preeclampsia among pregnant women attending antenatal care at a private healthcare facility in Bhubaneswar, Odisha.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>\n                      A hospital-based prospective case-control study was conducted, including pregnant women diagnosed with preeclampsia (both mild and severe) and normotensive controls. Platelet indices were measured at the time of delivery and compared across groups. Statistical analysis included ANOVA and\n                      <jats:italic toggle=\"yes\">post hoc<\/jats:italic>\n                      test for group comparisons and for relationship between platelet indices and disease severity. ROC curve analysis for diagnostic performance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      A significant decrease in platelet count was observed in pre-eclamptic women compared to normotensive controls (mean platelet count: 2.38 \u00b1 0.44 \u00d7 10\n                      <jats:sup>3<\/jats:sup>\n                      \/\u00b5l in normotensive, 2.14 \u00b1 0.47 \u00d7 10\n                      <jats:sup>3<\/jats:sup>\n                      \/\u00b5l in mild preeclampsia, and 1.90 \u00b1 0.312 \u00d7 10\n                      <jats:sup>3<\/jats:sup>\n                      \/\u00b5l in severe preeclampsia). In contrast, platelet indices such as MPV, PDW, PCT, and P-LCR were elevated in preeclampsia, with levels increasing in proportion to disease severity, except for PCT, which showed an inconsistent pattern. ROC analysis demonstrated that PDW (AUC: 0.622,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.004), PCT (AUC: 0.712,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01), and MPV (AUC: 0.678,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01) had diagnostic significance, suggesting their potential role in predicting disease severity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>Platelet indices, particularly PDW, MPV, and PCT, are significantly associated with preeclampsia and its severity. Incorporating these markers into routine antenatal screening could aid in early risk stratification. However, further multicenter studies and longitudinal follow-ups are recommended to establish standardized diagnostic cut-offs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jehp.jehp_835_25","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T15:01:21Z","timestamp":1778166081000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic and prognostic role of platelet indices in pre-eclampsia: Insights from a hospital-based study in Eastern part of India"],"prefix":"10.4103","volume":"15","author":[{"given":"Sura Sai","family":"Rashmi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Government Medical College, Maheswaram, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manasi","family":"Patnaik","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Kalinga Institute of Medical Sciences, KIIT University, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snigdha","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Kalinga Institute of Medical Sciences, KIIT University, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lipipuspa","family":"Pattnaik","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Kalinga Institute of Medical Sciences, KIIT University, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhusmita","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kalinga Institute of Medical Sciences, KIIT University, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,4]]},"reference":[{"key":"R1-20260507","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.preghy.2018.10.011","article-title":"Preeclampsia: Disease biology and burden, its management strategies with reference to India","volume":"15","author":"Malik","year":"2019","journal-title":"Pregnancy Hypertens"},{"key":"R2-20260507","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/HYPERTENSIONAHA.117.10803","article-title":"Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for international practice","volume":"72","author":"Brown","year":"2018","journal-title":"Hypertension"},{"key":"R3-20260507","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1111\/j.1471-0528.2012.03460.x","article-title":"Hypertensive disorders in pregnancy and fetal death at different gestational lengths: A population study of 2 121 371 pregnancies","volume":"119","author":"Ahmad","year":"2012","journal-title":"BJOG"},{"key":"R4-20260507","doi-asserted-by":"crossref","first-page":"1","DOI":"10.23937\/2474-3690\/1510024","article-title":"Preeclampsia: Pathophysiology and the maternal-fetal risk","volume":"3","author":"Khalil","year":"2017","journal-title":"J Hypertens Manag"},{"key":"R5-20260507","first-page":"1122","article-title":"Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists\u2019 task force on hypertension in pregnancy","volume":"122","year":"2013","journal-title":"Obstet Gynecol"},{"key":"R6-20260507","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12884-021-03809-2","article-title":"Epidemiological trends of maternal hypertensive disorders of pregnancy at the global, regional, and national levels: A population\u2010based study","volume":"21","author":"Wang","year":"2021","journal-title":"BMC Pregnancy Childbirth"},{"key":"R7-20260507","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5005\/jp-journals-10006-1164","article-title":"Predictive value of platelet indices in development of preeclampsia","volume":"4","author":"Dadhich","year":"2012","journal-title":"J SAFOG"},{"key":"R8-20260507","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.semnephrol.2010.10.004","article-title":"Angiogenic factors and preeclampsia","volume":"31","author":"Maynard","year":"2011","journal-title":"Semin Nephrol"},{"issue":"1","key":"R9-20260507","first-page":"397","article-title":"Thrombocytopenia in pregnancy","volume":"2010","author":"McCrae","year":"2010","journal-title":"Hematology 2010, the American Society of Hematology Education Program Book."},{"key":"R10-20260507","first-page":"71","article-title":"Platelet indices among Sudanese pregnant women with medical disorders association, a cross-sectional study in port Sudan city","volume":"6","author":"Bashir","year":"2017","journal-title":"Int J Sci"},{"issue":"1","key":"R11-20260507","first-page":"55","article-title":"Thrombocytopenia in pregnancy","volume":"11","author":"Ciobanu","year":"2016","journal-title":"Maedica."},{"key":"R12-20260507","first-page":"55","article-title":"Thrombocytopenia in pregnancy","volume":"11","author":"Ciobanu","year":"2016","journal-title":"Maedica"},{"key":"R13-20260507","first-page":"38","article-title":"How I treat thrombocytopenia in pregnancy","volume":"121","author":"Gernsheimer","year":"2013","journal-title":"Blood J Am Soc Hematol"},{"key":"R14-20260507","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1179\/1607845413Y.0000000098","article-title":"Preeclampsia: Are platelet count and indices useful for its prognostic?","volume":"18","author":"Freitas","year":"2013","journal-title":"Hematology"},{"key":"R15-20260507","first-page":"90","article-title":"Platelets in pregnancy","volume":"5","author":"Piazze","year":"2011","journal-title":"J Prenat Med"},{"key":"R16-20260507","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3109\/10641955.2012.704109","article-title":"Is there an association between platelet count during the first trimester and preeclampsia or other obstetric complications later in pregnancy?","volume":"32","author":"Tzur","year":"2013","journal-title":"Hypertens Pregnancy"},{"key":"R17-20260507","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/j.1365-2141.2004.05357.x","article-title":"Platelet size deviation width, platelet large cell ratio, and mean platelet volume have sufficient sensitivity and specificity in the diagnosis of immune thrombocytopenia","volume":"128","author":"Kaito","year":"2005","journal-title":"Br J Haematol"},{"key":"R18-20260507","doi-asserted-by":"crossref","first-page":"e91198","DOI":"10.1371\/journal.pone.0091198","article-title":"Risk factors of preeclampsia\/eclampsia and its adverse outcomes in low- and middle income countries: A WHO secondary analysis","volume":"9","author":"Luanni","year":"2014","journal-title":"PLoS One"},{"key":"R19-20260507","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1471-0528.2000.tb11582.x","article-title":"Risk factors for pre\u2010eclampsia in a large cohort of Latin American and Caribbean women","volume":"107","author":"Conde\u2010Agudelo","year":"2000","journal-title":"BJOG"},{"key":"R20-20260507","doi-asserted-by":"crossref","first-page":"172","DOI":"10.5530\/ijmedph.2017.3.35","article-title":"Risk factor assessment for preeclampsia: A case control study","volume":"7","author":"Verma","year":"2017","journal-title":"Int J Med Public Health"},{"issue":"2","key":"R21-20260507","first-page":"57","article-title":"The role of platelet parameters as a biomarker in the diagnosis and predicting the severity of preeclampsia","volume":"2","author":"Amita","year":"2015","journal-title":"Indian J Pathol Oncol"},{"key":"R22-20260507","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1111\/j.1471-0528.2005.00565.x","article-title":"Outcomes of severe pre\u2010eclampsia\/eclampsia in Yorkshire 1999\/2003","volume":"112","author":"Tuffnell","year":"2005","journal-title":"BJOG"},{"key":"R23-20260507","doi-asserted-by":"crossref","first-page":"e08484","DOI":"10.1016\/j.heliyon.2021.e08484","article-title":"Correlation of platelet parameters with adverse maternal and neonatal outcomes in severe preeclampsia: A case-control study","volume":"7","author":"Umezuluike","year":"2021","journal-title":"Heliyon"},{"key":"R24-20260507","doi-asserted-by":"crossref","first-page":"166","DOI":"10.4103\/PMRR.PMRR_28_24","article-title":"Modified BG Prasad and modified Kuppuswami socio-economic status scales: Revision and updates for January 2024","volume":"1","author":"Mohanty","year":"2024","journal-title":"Prevent Med Res Rev"},{"key":"R25-20260507","doi-asserted-by":"crossref","first-page":"359","DOI":"10.4103\/jehp.jehp_1097_23","article-title":"Effect of hypnosis on anxiety and blood pressure of pregnant women with preeclampsia: A double-blind controlled clinical trial study","volume":"13","author":"Seitz","year":"2024","journal-title":"J Educ Health Promot"},{"key":"R26-20260507","doi-asserted-by":"crossref","first-page":"110","DOI":"10.4103\/jehp.jehp_116_17","article-title":"Comparing the effects of simulation-based training, blended, and lecture on the simulated performance of midwives in preeclampsia and eclampsia","volume":"7","author":"Tabatabaeian","year":"2018","journal-title":"J Educ Health Promot"},{"key":"R27-20260507","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.18203\/2320-1770.ijrcog20201795","article-title":"Role of platelet distribution width and plateletcrit in assessment of nonthrombocytopenic preeclampsia and eclampsia in a tertiary care hospital of Odisha: An observational study","volume":"9","author":"Mohapatra","year":"2020","journal-title":"Int J Reprod Contracept Obstet Gynecol"},{"key":"R28-20260507","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ejogrb.2013.12.036","article-title":"Significance of the platelet distribution width as a severity marker for the development of preeclampsia","volume":"175","author":"Yang","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"R29-20260507","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s13224-017-1036-x","article-title":"Role of platelet distribution width (PDW) and plateletcrit in the assessment of nonthrombocytopenic preeclampsia and eclampsia","volume":"68","author":"Singh","year":"2018","journal-title":"J Obstet Gynecol India"},{"key":"R30-20260507","doi-asserted-by":"crossref","first-page":"e24305","DOI":"10.1002\/jcla.24305","article-title":"The role of platelet parameters for the diagnosis of preeclampsia among pregnant women attending at the University of Gondar Comprehensive Specialized Hospital antenatal care unit, Gondar, Ethiopia","volume":"36","author":"Walle","year":"2022","journal-title":"J Clin Lab Anal"},{"key":"R31-20260507","doi-asserted-by":"crossref","first-page":"792","DOI":"10.5603\/GP.a2021.0056","article-title":"Role of platelet indices in prediction of preeclampsia","volume":"92","author":"Temur","year":"2021","journal-title":"Ginekol Pol"}],"container-title":["Journal of Education and Health Promotion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jehp.jehp_835_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:27:15Z","timestamp":1786724835000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jehp.jehp_835_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/jehp.jehp_835_25","relation":{},"ISSN":["2277-9531","2319-6440"],"issn-type":[{"value":"2277-9531","type":"print"},{"value":"2319-6440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-05-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}