{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:27:42Z","timestamp":1786728462014,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Spinal anesthesia is the method of choice for cesarean section (CS). This method poses risks such as maternal hypotension. Measures such as prescribing appropriate preventative medications can be an important strategy in the prevention and treatment of hypotension in mothers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>\n                      This quasi-experimental study was conducted at Arash Hospital, Tehran University of Medical Sciences, on 110 patients undergoing CS under spinal anesthesia. Then, patients who met the necessary conditions were randomly divided into one of two groups: ondansetron (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 55) and phenylephrine (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 55). After spinal anesthesia, one group received an intravenous dose of 100 micrograms of phenylephrine and the other group received 4 mg of ondansetron. During the procedure, the patient\u2019s blood pressure and heart rate were measured every 2 minutes for 20 minutes and then every 5 minutes until the end of the procedure. Data were collected using a researcher-made questionnaire that included demographic information. A\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value &lt; 0.05 will be considered significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      The mean age of all participants was 30.08 years, with a standard deviation of 5.90 years. Nausea occurred in 21 of the 110 participants (19.09%) during the surgical procedure. It was more common in the phenylephrine group, affecting 14 patients (25.45%), compared to only 7 patients (12.73%) in the ondansetron group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.089). Vomiting was a relatively rare event, occurring in only 4 participants (3.64%) across both groups. Of these, 3 cases (5.45%) were in the phenylephrine group, while only 1 case (1.82%) occurred in the ondansetron group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.308).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>The findings revealed that while both agents were effective in managing maternal hemodynamics during surgery, ondansetron was associated with a significantly lower need for repeat antiemetic administration and reduced nausea and vomiting without increasing the risk of hypotension or bradycardia. Therefore, this finding may be useful for clinical practice and further studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jehp.jehp_952_25","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T15:01:10Z","timestamp":1778166070000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparing ondansetron versus phenylephrine in reduce the incidence of hypotension after spinal anesthesia in cesarean section"],"prefix":"10.4103","volume":"15","author":[{"given":"Masoomeh Nataj","family":"Majd","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Arash Women\u2019s Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afzal","family":"Shamsi","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israa Hussein","family":"Ali Alallo","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Parnian","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,4]]},"reference":[{"key":"R1-20260507","doi-asserted-by":"crossref","first-page":"357","DOI":"10.4103\/jehp.jehp_923_22","article-title":"Cesarean section or normal vaginal delivery: A cross-sectional study of attitude of medical students","volume":"11","author":"Saraf","year":"2022","journal-title":"J Edu Health Promot"},{"key":"R2-20260507","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3390\/ph18030392","article-title":"The impact of fentanyl and morphine on maternal hemodynamics in spinal anesthesia for cesarean section","volume":"18","author":"Moisa","year":"2025","journal-title":"Pharmaceuticals (Basel)"},{"key":"R3-20260507","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1213\/ANE.0000000000004534","article-title":"A Prospective, randomized, double-blinded study of the effect of intravenous ondansetron on the effective dose in 50% of subjects of prophylactic phenylephrine infusions for preventing spinal anesthesia-induced hypotension during cesarean delivery","volume":"131","author":"Xiao","year":"2020","journal-title":"Anesth Analg"},{"key":"R4-20260507","first-page":"103","article-title":"Effect of ondansetron in preventing spinal anesthesia-induced hypotension in pregnant women undergoing elective cesarean section","volume":"4","author":"Hoseinikhah","year":"2025","journal-title":"GMJ Medicine"},{"key":"R5-20260507","first-page":"e49886","article-title":"Risk factors in administering spinal anesthesia: A comprehensive review","volume":"15","author":"Doelakeh","year":"2023","journal-title":"Cureus"},{"key":"R6-20260507","doi-asserted-by":"crossref","first-page":"374","DOI":"10.4103\/jehp.jehp_762_21","article-title":"Development and implementation of anxiety management program for women under gynecological surgery with spinal anesthesia: Protocol of action research study","volume":"11","author":"Halakou","year":"2022","journal-title":"J Edu Health Promot"},{"key":"R7-20260507","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1097\/CM9.0000000000001477","article-title":"Effects of colloid preload on the incidence of hypotension in spinal anesthesia for cesarean section: A systematic review and meta-analysis","volume":"134","author":"Gong","year":"2021","journal-title":"Chin Med J (Engl)"},{"key":"R8-20260507","doi-asserted-by":"crossref","first-page":"103175","DOI":"10.1016\/j.ijoa.2021.103175","article-title":"Prediction of spinal anesthesia-induced hypotension during elective cesarean section: A systematic review of prospective observational studies","volume":"47","author":"Yu","year":"2021","journal-title":"Int J Obstet Anesth"},{"key":"R9-20260507","doi-asserted-by":"crossref","first-page":"226","DOI":"10.4103\/aer.aer_48_22","article-title":"Comparison of prophylactic phenylephrine infusion versus intravenous ondansetron on hypotension during spinal anesthesia for cesarean section","volume":"16","author":"Ali","year":"2022","journal-title":"Anesth Essays Res"},{"key":"R10-20260507","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1111\/j.1399-6576.2011.02646.x","article-title":"Vasopressors for the management of hypotension after spinal anesthesia for elective caesarean section. Systematic review and cumulative meta-analysis","volume":"56","author":"Veeser","year":"2012","journal-title":"Acta Anaesthesiol Scand"},{"key":"R11-20260507","doi-asserted-by":"crossref","first-page":"103542","DOI":"10.1016\/j.ijoa.2022.103542","article-title":"Effect of low-dose phenylephrine infusion on shivering and hypothermia in patients undergoing cesarean section under spinal anesthesia: A randomized clinical trial","volume":"50","author":"Palanisamy","year":"2022","journal-title":"Int J Obstet Anesth"},{"key":"R12-20260507","doi-asserted-by":"crossref","first-page":"1194196","DOI":"10.3389\/fphar.2024.1194196","article-title":"Intravenous ondansetron for the prevention of supine hypotensive syndrome during spinal anesthesia for cesarean section: A randomized controlled trial","volume":"15","author":"Zhang","year":"2024","journal-title":"Front Pharmacol"},{"key":"R13-20260507","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.2147\/DDDT.S452983","article-title":"Dose-response study of phenylephrine for preventing spinal-induced hypotension during cesarean delivery with combined spinal-epidural anesthesia under the effect of prophylactic intravenous ondansetron","volume":"18","author":"Sun","year":"2024","journal-title":"Drug Des Devel Ther"},{"key":"R14-20260507","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.2147\/DDDT.S257880","article-title":"Does an earlier or later intravenous injection of ondansetron affect the dose of phenylephrine needed to prevent spinal-anesthesia induced hypotension in cesarean sections?","volume":"14","author":"Qian","year":"2020","journal-title":"Drug Des Devel Ther"},{"key":"R15-20260507","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12909-019-1453-x","article-title":"Preclinical curriculum of prospective case-based teaching with faculty- and student-blinded approach","volume":"19","author":"Waliany","year":"2019","journal-title":"BMC Med Educ"},{"key":"R16-20260507","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.3390\/ph15121588","article-title":"Ondansetron reduces the incidence of hypotension after spinal anaesthesia: A systematic review and meta-analysis","volume":"15","author":"Hou","year":"2022","journal-title":"Pharmaceuticals"},{"key":"R17-20260507","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1213\/ANE.0000000000004833","article-title":"Fourth consensus guidelines for the management of postoperative nausea and vomiting","volume":"131","author":"Gan","year":"2019","journal-title":"Anesth Analg"},{"key":"R18-20260507","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/aas.14225","article-title":"Incidence of bradycardia during noradrenaline or phenylephrine bolus treatment of postspinal hypotension in cesarean delivery: A randomized double-blinded controlled trial","volume":"67","author":"de Queiroz","year":"2023","journal-title":"Acta Anaesthesiol Scand"},{"key":"R19-20260507","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1111\/anae.14675","article-title":"A randomised controlled trial of phenylephrine and noradrenaline boluses for treatment of postspinal hypotension during elective caesarean section","volume":"74","author":"Mohta","year":"2019","journal-title":"Anaesthesia"},{"key":"R20-20260507","first-page":"e288","article-title":"Preemptive administration of ondansetron and phenylephrine for prevention of perioperative hypotension under spinal anesthesia for cesarean section: A quasi-experimental study","volume":"7","author":"Lakhe","year":"2020","journal-title":"JSAN"}],"container-title":["Journal of Education and Health Promotion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jehp.jehp_952_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:27:15Z","timestamp":1786724835000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jehp.jehp_952_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/jehp.jehp_952_25","relation":{},"ISSN":["2277-9531","2319-6440"],"issn-type":[{"value":"2277-9531","type":"print"},{"value":"2319-6440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-05-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-11","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}