{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:36:37Z","timestamp":1787841397419,"version":"build-2784847793"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n BACKGROUND:<\/jats:title>\n Since the advent of coronavirus disease 2019 (COVID-19) infection, there is debate whether pregnancy outcome in COVID-19 is more severe as compared to general population. Pregnant population is particularly susceptible to viral infections due to altered immune response. H1N1 infection and Zika virus infection led to unfavorable maternal and fetal outcomes. SARS during pregnancy has been linked previously with high risk of spontaneous abortions, preterm births and intrauterine growth restriction. The effects of this novel virus need to be studied.<\/jats:p>\n <\/jats:sec>\n \n MATERIALS AND METHODS:<\/jats:title>\n This is a single-center descriptive prospective observational study of 65 pregnant women with reverse transcriptase\u2013polymerase chain reaction confirmed COVID-19 infection, regardless of gestational age at diagnosis, admitted from April 15 to June 30, 2020, at the COVID hospital in SN Medical college a tertiary center of Agra in North India. Maternal and perinatal outcomes were studied. Data were analyzed using the SPSS software for windows. Continuous variables were expressed as mean \u00b1 standard deviation. Categorical variables were expressed as numbers and percentages.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n Majority 88.4% of the women were asymptomatic. Rest had mild illness only. Majority 94.23% were third-trimester pregnancies; preterm birth was not reported in any singleton pregnancy. Majority 85% were delivered by cesarean section done for obstetric indications. Maternal outcome of all patients was favourable, and only two women who had moderate pneumonia recovered. Maternal mortality was reported in only 1 case. All neonates were negative for COVID-19. Neonatal outcome was favorable.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n COVID-19 in pregnancy led to mild symptoms only. Infection in the third trimester did not led to adverse obstetric outcome including preterm labor and premature membrane rupture. SARSCoV2 infection in pregnancy did not increase the risk of maternal mortality. Vertical transmission of COVID-19 was not found in neonates. The maternal, neonatal, and perinatal outcomes of COVID-19 patients infected in late pregnancy were favorable.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jehp.jehp_954_20","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T12:47:54Z","timestamp":1713876474000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["Coronavirus disease 2019 in pregnancy: Maternal and perinatal outcome"],"prefix":"10.4103","volume":"10","author":[{"given":"Neha","family":"Agarwal","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, SN Medical College, Agra, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchika","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, SN Medical College, Agra, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saroj","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, SN Medical College, Agra, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arti","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Microbiology, SN Medical College, Agra, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,5]]},"reference":[{"key":"R1-20250921","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1056\/NEJMoa030781","article-title":"A novel coronavirus associated with severe acute respiratory syndrome","volume":"348","author":"Ksiazek","year":"2003","journal-title":"N Engl J Med"},{"key":"R2-20250921","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1056\/NEJMoa1211721","article-title":"Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia","volume":"367","author":"Zaki","year":"2012","journal-title":"N Engl J Med"},{"key":"R3-20250921","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.ajog.2003.11.019","article-title":"Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome","volume":"191","author":"Wong","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"R4-20250921","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(20)30251-8","article-title":"Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding","volume":"395","author":"Lu","year":"2020","journal-title":"Lancet"},{"key":"R5-20250921","doi-asserted-by":"crossref","first-page":"78","DOI":"10.4103\/jehp.jehp_189_20","article-title":"Novel coronavirus disease 2019 and perinatal outcomes","volume":"9","author":"Irani","year":"2020","journal-title":"J Educ Health Promot"},{"key":"R6-20250921","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4103\/jehp.jehp_483_20","article-title":"World one-hundred days after COVID-19 outbreak: Incidence, case fatality rate, and trend","volume":"9","author":"Kazemi-Karyani","year":"2020","journal-title":"J Educ Health Promot"},{"key":"R7-20250921","doi-asserted-by":"crossref","first-page":"7","DOI":"10.26502\/jppch.74050034","article-title":"Vertical transmission of COVID-19-A systematic review","volume":"4","author":"Fornari","year":"2020","journal-title":"J Pediatr Perinatol Child Health"},{"key":"R8-20250921","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1056\/NEJMc2009316","article-title":"Universal screening for SARS-CoV-2 in women admitted for delivery","volume":"382","author":"Sutton","year":"2020","journal-title":"N Engl J Med"},{"key":"R9-20250921","article-title":"Pregnancy outcomes, Newborn complications and Maternal-Fetal Transmission of SARS-CoV-2 in women with COVID-19: A systematic review of 441 cases. Preprint 15April 2020 medRxiv 2020PPR: PPR15125","author":"Gajbhiye"},{"key":"R10-20250921","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0140-6736(20)30360-3","article-title":"Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: A retrospective review of medical records","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet"},{"key":"R11-20250921","doi-asserted-by":"crossref","first-page":"e100","DOI":"10.1056\/NEJMc2009226","article-title":"Clinical Characteristics of Pregnant Women with Covid-19 in Wuhan, China","volume":"382","author":"Chen","year":"2020","journal-title":"N Engl J Med"},{"key":"R12-20250921","doi-asserted-by":"crossref","first-page":"914.e1","DOI":"10.1016\/j.ajog.2020.06.022","article-title":"Coronavirus disease 2019 in pregnancy was associated with maternal morbidity and preterm birth","volume":"223","author":"Sentilhes","year":"2020","journal-title":"Am J Obstet Gynecol"},{"issue":"7","key":"R13-20250921","doi-asserted-by":"crossref","first-page":"799","DOI":"10.5858\/arpa.2020-0901-SA","article-title":"An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: Maternal coronavirus infections and pregnancy outcomes","volume":"144","author":"Schwartz","year":"2020","journal-title":"Arch Pathol Lab Med"},{"key":"R14-20250921","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/frph.2020.00001","article-title":"Mild and asymptomatic Covid-19 infections: Implications for maternal, fetal, and reproductive health?","volume":"2","author":"Sun","year":"2020","journal-title":"Front Reprod Health"},{"key":"R15-20250921","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.ijid.2020.04.065","article-title":"Coronavirus disease 2019 in pregnancy","volume":"95","author":"Qiancheng","year":"2020","journal-title":"Int J Infect Dis"},{"key":"R16-20250921","doi-asserted-by":"crossref","first-page":"111.e1","DOI":"10.1016\/j.ajog.2020.04.014","article-title":"Coronavirus disease 2019 in pregnant women: A report based on 116 cases","volume":"223","author":"Yan","year":"2020","journal-title":"Am J Obstet Gynecol"},{"key":"R17-20250921","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2214\/AJR.20.23072","article-title":"Women with coronavirus disease (COVID-19) pneumonia: A preliminary analysis","volume":"215","author":"Liu","year":"2020","journal-title":"Am J Roentgenol"}],"container-title":["Journal of Education and Health Promotion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jehp.jehp_954_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:53:04Z","timestamp":1787838784000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jehp.jehp_954_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/jehp.jehp_954_20","relation":{},"ISSN":["2277-9531","2319-6440"],"issn-type":[{"value":"2277-9531","type":"print"},{"value":"2319-6440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"2020-08-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-09","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}