{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:22:37Z","timestamp":1787772157645,"version":"build-2784847793"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Literature on the frequency, response to treatment, and outcomes of acute ischemic stroke (AIS) due to intracranial atherostenosis (ICAS)-related intracranial large artery occlusion (ILAO) from Saudi Arabia is scarce. The aim of this study was to identify the percentage, describe the characteristics, and observe the treatment response in patients with AIS attributed to ICAS-related ILAO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>This cross-sectional study included all adult patients from 2017-2021 who fulfilled the inclusion criteria for the diagnosis of ICAS-related AIS. Patients were dichotomized based on ILAO. Mortality and functional outcomes (FOCs) based on 90 days\u2019 dependence level were compared between the two groups. The association between ILAO and other variables was assessed using the Chi-squared test, odds ratios (OR), and 95% confidence interval (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      ILAO was found in 38.7% of patients with ICAS-related AIS. Men comprised three-fourths of the cohort and were more frequent in the ILAO group. Smoking was associated with increased (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04) likelihood of ILAO. Patients with ILAO had more severe strokes (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.001) than patients without. Middle cerebral artery was the most common occluded vessel (52%). Functional dependence (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003, OR = 2.87, CI = 1.42\u20135.77), malignant transformation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001, OR = 8.0, CI = 1.82\u201335.9), and mortality (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.001, OR = 7.67, CI = 2.40\u201324.5) were significantly higher among ILAO group. Patients with ILAO with unfavorable FOC were older than those who achieved better FOC (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.001). Thrombolysis (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02, OR = 2.50, CI = 1.15\u20135.41) and mechanical thrombectomy (MT) improved FOC in patients with ILAO (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04, OR = 2.33, CI = 1.10\u20134.92).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>ILAO is common in patients with ICAS-related AIS. Timely hyperacute stroke treatment can help improve the FOC of otherwise disabling stroke due to ILAO. Raising awareness of the community about stroke is needed, so that a higher number of patients can arrive at hospital within the golden hours. Further data from the region are required to recognize the efficacy of MT in ICAS-related ILAO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfcm.jfcm_313_23","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T11:00:21Z","timestamp":1713178821000},"page":"140-147","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Characteristics and outcomes of large artery occlusion-related stroke due to intracranial atherostenosis: An experience from a single center in Saudi Arabia"],"prefix":"10.4103","volume":"31","author":[{"given":"Azra S.","family":"Zafar","sequence":"first","affiliation":[{"name":"Department of Neurology, College of Medicine and King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Dammam, Saudi 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A.","family":"Alkhamis","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine and King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erum M.","family":"Shariff","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine and King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majed M.","family":"Alabdali","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine and King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Nazish","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine and King Fahd 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