{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:39:59Z","timestamp":1790102399020,"version":"4.0.1"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Delayed recognition and treatment of vitamin A deficiency (VAD) in adults leads to devastating complications. A 24-year-old woman presented with diarrhea, malaise, and shortness of breath. Her medical history included blunt abdominal trauma for which, she had bowel resection surgery and revision surgery within a year of the last surgery at the age of 8 years. She had difficulty in night vision and dry eyes. The best-corrected visual acuity was 6\/18 in the BE. On slit-lamp examination in the both eyes (BE), the conjunctiva was thick, dry-looking with wrinkling, and the cornea had diffused superficial punctate keratitis and in the left eye, there was corneal xerosis of 1.5 \u00d7 1.5 mm. Tear film breakup time was 0-s in the BE. Schirmer's were 30 mm BE. The rest of the ocular examination was within normal limits. A clinical diagnosis of xerophthalmia secondary to malabsorption was made and treated with systemic vitamin A and intense lubrication. With time, ophthalmic conditions improved, but she died due to poor general wellbeing and repeated hospital-acquired infections. The infrequent presentation of VAD in adults and the unusual etiology in this patient make this case interesting, whereas its potentially devastating consequences highlight the importance of its early recognition, treatment, and regular follow up needed by both patient and physician in the community (general practitioner and ophthalmologists) for the prevention of VAD complications and poor prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_1020_21","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T10:04:42Z","timestamp":1633428282000},"page":"3515-3518","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Xerophthalmia with secondary malabsorption syndrome in a young lady"],"prefix":"10.4103","volume":"10","author":[{"given":"Shama Irfan","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasan Kumar","family":"Panda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeti","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-61-20240828","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000185254","article-title":"Xerophthalmia","volume":"103","author":"McLaren","year":"2012","journal-title":"World Rev Nutr Diet"},{"key":"R2-61-20240828","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.ophtha.2004.12.045","article-title":"Ocular complications of hypovitaminosis after bariatric surgery","volume":"112","author":"Lee","year":"2005","journal-title":"Ophthalmology"},{"key":"R3-61-20240828","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1136\/bjo.2006.092502","article-title":"Vitamin A deficiency in patients with a remote history of intestinal surgery","volume":"90","author":"Chae","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"R5-61-20240828","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1053\/gast.1997.v113.pm9352883","article-title":"Short-bowel syndrome in children and adults","volume":"113","author":"Vanderhoof","year":"1997","journal-title":"Gastroenterology"},{"key":"R6-61-20240828","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000310270","article-title":"Xerophthalmia in liver cirrhosis. Correct diagnosis after 15 years","volume":"204","author":"Ettl","year":"1992","journal-title":"Ophthalmologica"},{"key":"R7-61-20240828","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1136\/bjo.67.1.37","article-title":"Night vision in a case of vitamin A deficiency due to malabsorption","volume":"67","author":"Perlman","year":"1983","journal-title":"Br J Ophthalmol"},{"key":"R8-61-20240828","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3923\/ajcn.2009.65.82","article-title":"Vitamin A: A review","volume":"1","author":"Edem","year":"2009","journal-title":"Asian J Clin Nutr"},{"key":"R9-61-20240828","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1515\/CCLM.2003.151","article-title":"Factors affecting intestinal absorption of highly lipophilic food microconstituents (fat soluble vitamins, carotenoids and phytosterols)","volume":"41","author":"Borel","year":"2003","journal-title":"Clin Chem Lab Med"},{"key":"R10-61-20240828","first-page":"66","article-title":"The eye signs of vitamin A deficiency","volume":"26","author":"Gilbert","year":"2013","journal-title":"Community Eye Health"},{"key":"R11-61-20240828","doi-asserted-by":"crossref","first-page":"2902S","DOI":"10.1093\/jn\/132.9.2902S","article-title":"Recommendations for vitamin A supplementation","volume":"132","author":"Ross","year":"2002","journal-title":"J Nutr"},{"key":"R12-61-20240828","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1136\/bjo.2003.022459","article-title":"Rapid recovery of night blindness due to obesity surgery after vitamin A repletion therapy","volume":"88","author":"Spits","year":"2003","journal-title":"Br J Ophthalmol"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1020_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:08:07Z","timestamp":1787166487000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1020_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":11,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_1020_21","relation":{},"ISSN":["2249-4863"],"issn-type":[{"value":"2249-4863","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]}}}