{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:00:56Z","timestamp":1787169656926,"version":"build-2736575974"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>A five-month-old infant presented with fever and cough for 3 weeks. She was diagnosed with multiple tuberculomas and cavitating pulmonary tuberculosis. She was a household contact of an open case of tuberculosis (TB) and developed severe disease, although she had received the Bacillus Calmette\u2013Gu\u00e9rin (BCG) vaccine and had no primary or secondary immunodeficiency. In infants, due to low levels of cell mediated immunity, tuberculosis can be severe and dissemination of tuberculosis to the central nervous system (CNS) can occur very early without following the usual time frame. CNS TB may not have symptoms in the early stages in infants and may require neuroimaging for diagnosis. This is the youngest child that has been reported with multiple CNS tuberculomas.<\/jats:p>","DOI":"10.4103\/jfmpc.jfmpc_1021_21","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T01:12:59Z","timestamp":1648516379000},"page":"1536-1538","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Multiple tuberculomas and cavitating pulmonary tuberculosis in an infant"],"prefix":"10.4103","volume":"11","author":[{"given":"Rachel Ranitha","family":"Peterson","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Bangalore Baptist Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ramya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Bangalore Baptist Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha","family":"Kuruvilla","sequence":"additional","affiliation":[{"name":"Department of Radiology, Bangalore Baptist Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. S.","family":"Lakshmi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Bangalore Baptist Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,3,18]]},"reference":[{"issue":"(Suppl 1)","key":"B1-20240828","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1471-2334-14-S1-S4","article-title":"Clinical peculiarities of tuberculosis","volume":"14","author":"Piccini","year":"2014","journal-title":"BMC Infect Dis"},{"key":"B3-20240828","first-page":"1445","author":"Hatzenbuehler","year":"2016","journal-title":"Tuberculosis (Mycobacterium tuberculosis)"},{"key":"B4-20240828","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/781320","article-title":"Immune vulnerability of infants to tuberculosis","volume":"2013","author":"Vanden Driessche","year":"2013","journal-title":"Clin Dev Immunol"},{"key":"B8-20240828","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/cid\/cit790","article-title":"Protection by BCG vaccine against tuberculosis:A systematic review of randomized controlled trials","volume":"58","author":"Mangtani","year":"2014","journal-title":"Clin Infect Dis"},{"key":"B9-20240828","first-page":"93","author":"Shivananda","year":"2020","journal-title":"Bacillus Calmette Guerin (BCG) Vaccine. In:IAP GUidebookon Immunization 2018-2019"},{"key":"B10-20240828","first-page":"1","article-title":"Bacille Calmette-Guerin (BCG) revaccination:Is it beneficial for tuberculosis control?","volume":"2","author":"Ahmad","year":"2013","journal-title":"Sci Rep"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1021_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:11:36Z","timestamp":1787166696000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1021_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,18]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_1021_21","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,18]]},"assertion":[{"value":"2021-05-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-19","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}