{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:44:07Z","timestamp":1786653847649,"version":"build-2736575974"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12]]},"abstract":"\n Background:<\/jats:title>\n \n Helicobacter pylorus<\/jats:italic>\n is one of the most common bacterial infections affecting the world\u2019s population. Peptic ulcer disease is caused by\n H. pylori<\/jats:italic>\n and the use of nonsteroidal anti-inflammatory drugs. The aim of this study was to assessment of two antibiotic regimens in the treatment of\n H. pylori<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n A total of 220\n H. pylori<\/jats:italic>\n infected patients were enrolled in the randomized clinical trial that referred to Imam Khomeini Hospital gasterointestinal clinic, Ahvaz. Patients were allocated into two groups randomly. Group 1 received the 14-day proton pump inhibitor (PPI) amoxicillin-containing high-dose therapy and group II received the bismuth-containing quadruple therapy. Basic characteristics, adverse events, and eradication rates were compared between two groups.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The PPI\u2013amoxicillin-containing high-dose therapy group achieved eradication rates of 73.6% and 72.4% as determined by the intention-to-treat and per-protocol analyses, respectively (\n P<\/jats:italic>\n > 0.05). The eradication rates at bismuth-containing quadruple therapy group were 77.2% and 76.1%, respectively, (\n P<\/jats:italic>\n > 0.05). Also, there were no significant differences in the compliance rates and adverse effects between two groups (\n P<\/jats:italic>\n > 0.05). Furthermore, the cost of medications in the PPI\u2013amoxicillin-containing high-dose therapy was significantly lower compared with that in the quadruple therapy contained bismuth.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n PPI\u2013amoxicillin-containing high-dose treatment regimen can be used especially in the pregnancy and lactating patient or low-economic patient because safer and less costly compared with bismuth-containing quadruple therapy.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_1035_22","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T03:51:56Z","timestamp":1675050716000},"page":"7806-7809","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Eradication efficacy of high-dose amoxicillin and proton pump inhibitor compared with quadruple therapy contained bismuth in the treatment of Helicobacter pylori"],"prefix":"10.4103","volume":"11","author":[{"given":"Eskandar","family":"Hajiani","sequence":"first","affiliation":[{"name":"Research Institute for Infectious Diseases of Digestive System, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seid Jalal","family":"Hashemi","sequence":"additional","affiliation":[{"name":"Research Institute for Infectious Diseases of Digestive System, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abazar","family":"Parsi","sequence":"additional","affiliation":[{"name":"Research Institute for Infectious Diseases of Digestive System, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seid Saeed","family":"Seyedian","sequence":"additional","affiliation":[{"name":"Research Institute for Infectious Diseases of Digestive System, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayeb","family":"Ramim","sequence":"additional","affiliation":[{"name":"Department of Health Information Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Sabbaghan","sequence":"additional","affiliation":[{"name":"Research Institute for Infectious Diseases of Digestive System, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"R1-20260204","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1056\/NEJMra020542","article-title":"Helicobacter pylori infection","volume":"347","author":"Suerbaum","year":"2002","journal-title":"N Engl J Med"},{"key":"R2-20260204","first-page":"88","article-title":"Clarithromycin vs. gemifloxacin in quadruple therapy regimens for empiric primary treatment of helicobacter pylori infection: Arandomized clinical trial","volume":"7","author":"Masoodi","year":"2015","journal-title":"Middle East J Dig Dis"},{"issue":"Suppl 1","key":"R3-20260204","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1523-5378.2011.00874.x","article-title":"Epidemiology of helicobacter pylori infection and public health implications","volume":"16","author":"Goh","year":"2011","journal-title":"Helicobacter"},{"key":"R4-20260204","doi-asserted-by":"crossref","first-page":"5578","DOI":"10.3748\/wjg.v25.i37.5578","article-title":"Pathogenesis and clinical management of Helicobacter pylori gastric infection","volume":"25","author":"de Brito","year":"2019","journal-title":"World J Gastroenterol"},{"key":"R5-20260204","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.3748\/wjg.v24.i22.2373","article-title":"Treatment of helicobacter pylori infection in atrophic gastritis","volume":"24","author":"Lahner","year":"2018","journal-title":"World J Gastroenterol"},{"key":"R6-20260204","first-page":"4791","article-title":"Comparison of esophageal function tests to investigate the effect of helicobacter pylori infection on gastroesophageal reflux disease (GERD)","volume":"24","author":"Liu","year":"2018","journal-title":"Med SciMonit"},{"key":"R7-20260204","doi-asserted-by":"crossref","first-page":"e013248","DOI":"10.1136\/bmjopen-2016-013248","article-title":"Accuracy of testing for anti-helicobacter pylori IgG in urine for H. pylori infection diagnosis: A systematic review and meta-analysis","volume":"7","author":"Gong","year":"2017","journal-title":"BMJ Open"},{"key":"R8-20260204","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.3748\/wjg.v22.i3.1311","article-title":"Helicobacter pylori associated gastric intestinal metaplasia: Treatment and surveillance","volume":"22","author":"Liu","year":"2016","journal-title":"World J Gastroenterol"},{"key":"R9-20260204","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/hel.12031","article-title":"Prevalence of primary and secondary antimicrobial resistance of helicobacter pylori in Korea from 2003 through 2012","volume":"18","author":"Lee","year":"2013","journal-title":"Helicobacter"},{"key":"R10-20260204","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1136\/gutjnl-2012-302084","article-title":"Management of helicobacter pylori infection\u2014The Maastricht IV\/Florence consensus report","volume":"61","author":"Malfertheiner","year":"2012","journal-title":"Gut"},{"key":"R11-20260204","doi-asserted-by":"crossref","first-page":"7235","DOI":"10.1073\/pnas.0702300104","article-title":"Gene expression in vivo shows that helicobacter pylori colonizes an acidic niche on the gastric surface","volume":"104","author":"Scott","year":"2007","journal-title":"ProcNatlAcadSci U S A"},{"key":"R12-20260204","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1136\/gutjnl-2015-309252","article-title":"Kyoto global consensus report on Helicobacter pylori gastritis","volume":"64","author":"Sugano","year":"2015","journal-title":"Gut"},{"key":"R13-20260204","first-page":"448","article-title":"High-dose esomeprazole and amoxicillin dual therapy for first-line Helicobacter pylori eradication: Aproof of concept study","volume":"28","author":"Zullo","year":"2015","journal-title":"Ann Gastroenterol"},{"key":"R14-20260204","doi-asserted-by":"crossref","first-page":"437","DOI":"10.14309\/ajg.0000000000000132","article-title":"Eradication efficacy of modified dual therapy compared with bismuth-containing quadruple therapy as a first line treatment of helicobacter pylori","volume":"114","author":"Jing","year":"2019","journal-title":"Am J Gastroenterol"},{"key":"R15-20260204","first-page":"1718","article-title":"A day esomeprazole- and amoxicillin-containing high-dose dual therapy regimen achieves a high eradication rate as first-line anti-Helicobacter pylori treatment in Taiwan: Aprospective randomized trial","volume":"74","author":"Tai","year":"2019","journal-title":"J AntimicrobChemother"},{"key":"R16-20260204","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1648047","article-title":"High dose ilaprazole\/amoxicillin as first-line regimen for helicobacter pylori infection in Korea","author":"Kwack","year":"2016","journal-title":"Gastroenterol Res Pract 2016"}],"container-title":["Journal of Family Medicine and Primary 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History"}},{"value":"2022-08-27","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}