{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:38:13Z","timestamp":1786649893641,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Patients with allergic rhinitis (AR) usually present with symptoms such as frequent sneezing, nasal obstruction, a runny nose, and nasal itching. Allergic eye symptoms, such as itchy eyes, epiphora, and redness, might coexist with nasal symptoms, potentially worsening the severity of the condition and impairing quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed to assess the frequency and severity of allergic nasal and ocular symptoms in individuals diagnosed with AR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This cross-sectional study was conducted from April 2024 to March 2025. The study population included 438 adults diagnosed with AR, who exhibited at least two allergic symptoms. The participants were recruited through an ENT clinic and completed a self-administered questionnaire. Symptom severity was measured using a 4-point Likert scale. Spearman\u2019s rank correlation coefficient was used to assess the relationship between the summed severity of nasal symptoms with that of ocular symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of the 438 participants, 86.1% reported at least one allergic ocular symptom. Frequent sneezing (83.3%) and nasal obstruction (80.1%) were the most prevalent nasal symptoms, whereas itchy eyes (76.5%) were the most common ocular symptom. A significant moderate correlation was found between the summed severities of nasal and ocular symptoms (rho = 0.436,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study highlights the significant co-occurrence and association between nasal and ocular symptoms in patients with AR. These findings underscore the importance of considering both nasal and ocular symptoms in the clinical management of AR to improve patient outcomes and quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_1068_25","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T13:01:08Z","timestamp":1767013268000},"page":"5212-5216","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Interplay and severity of nasal and ocular symptoms in allergic rhinitis"],"prefix":"10.4103","volume":"14","author":[{"given":"Manal M.","family":"Al-Surayhi","sequence":"first","affiliation":[{"name":"Department of Surgery, College of Medicine, Taif University, Taif, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahya A.","family":"Fageeh","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, Taif University, Taif, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"key":"R1-20251230","first-page":"8","article-title":"Relationship between allergic rhinitis and allergic conjunctivitis (allergic rhinoconjunctivitis) \u2013 review","volume":"66","author":"Iordache","year":"2022","journal-title":"Rom J Ophthalmol"},{"key":"R2-20251230","first-page":"e2020007","article-title":"Allergic rhinoconjunctivitis","volume":"91","author":"Del Giudice","year":"2020","journal-title":"Acta Biome"},{"key":"R3-20251230","doi-asserted-by":"crossref","first-page":"44","DOI":"10.29262\/ram.v66i1.570","article-title":"Diagnosis of allergic sensitization in patients with allergic rhinitis and asthma in a tropical environment","volume":"66","author":"S\u00e1nchez-Borges","year":"2019","journal-title":"Rev Alerg Mex"},{"key":"R4-20251230","doi-asserted-by":"crossref","first-page":"83","DOI":"10.18231\/j.ijceo.2021.017","article-title":"Prevalence and risk factors of allergic conjunctivitis in a semi urban set up","volume":"7","author":"Charani","year":"2021","journal-title":"Indian J Clin Exp Ophthalmol"},{"key":"R5-20251230","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.jaci.2017.03.050","article-title":"Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines-2016 revision","volume":"140","author":"Bro\u017cek","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"R6-20251230","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.anai.2018.03.028","article-title":"The burden of allergic rhinitis and allergic rhinoconjunctivitis on adolescents: A literature review","volume":"121","author":"Blaiss","year":"2018","journal-title":"Ann Allergy Asthma Immunol"},{"key":"R7-20251230","first-page":"330","article-title":"Effectiveness of intranasal corticosteroids for sleep disturbances in patients with allergic rhinitis: A systematic review and meta-analysis","volume":"186","author":"Tabata","year":"2025","journal-title":"Int Arch Allergy Immunol"},{"key":"R8-20251230","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/j.jaip.2024.01.038","article-title":"Sublingual tablet immunotherapy improves quality of life in adults with allergic rhinoconjunctivitis","volume":"12","author":"Blaiss","year":"2024","journal-title":"J Allergy Clin Immunol Pract"},{"key":"R9-20251230","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.2147\/JAA.S391142","article-title":"The prevalence, clinical picture, and triggers of allergic rhinitis in Saudi population: A systematic review and meta-analysis","volume":"15","author":"Aburiziza","year":"2022","journal-title":"J Asthma Allergy"},{"key":"R10-20251230","first-page":"25158414241294020","article-title":"Clinical characteristics of allergic conjunctivitis in the Southern region of Saudi Arabia: A cross-sectional study","volume":"16","author":"ALDhabaan","year":"2024","journal-title":"Ther Adv Ophthalmol"},{"key":"R11-20251230","doi-asserted-by":"crossref","first-page":"357","DOI":"10.5144\/0256-4947.2017.357","article-title":"Validation of the Arabic version of the score for allergic rhinitis tool","volume":"37","author":"Alharethy","year":"2017","journal-title":"Ann Saudi Med"},{"key":"R12-20251230","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.anai.2014.02.006","article-title":"Diagnosis and treatment of nasal and ocular allergies: The Allergies, Immunotherapy, and rhinoconjunctivitis (AIRS) surveys","volume":"112","author":"Blaiss","year":"2014","journal-title":"Ann Allergy Asthma Immunol"},{"key":"R13-20251230","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4103\/ojo.OJO_31_2019","article-title":"Prevalence and causative agents of allergic conjunctivitis and its determinants in adult citizens of Western Saudi Arabia: A survey","volume":"13","author":"Alqurashi","year":"2020","journal-title":"Oman J Ophthalmol"},{"key":"R14-20251230","doi-asserted-by":"crossref","first-page":"277","DOI":"10.23822\/EurAnnACI.1764-1489.231","article-title":"Severity and duration of allergic conjunctivitis: Are they associated with severity and duration of allergic rhinitis and asthma?","volume":"54","author":"S\u00e1nchez-Hern\u00e1ndez","year":"2022","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"R15-20251230","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1159\/000334286","article-title":"The burden associated with ocular symptoms in allergic rhinitis","volume":"158","author":"Klossek","year":"2012","journal-title":"Int Arch Allergy Immunol"},{"key":"R16-20251230","doi-asserted-by":"crossref","first-page":"e135","DOI":"10.2500\/ajra.2013.27.3937","article-title":"Prevalence of ocular symptoms in patients with allergic rhinitis: Korean multicenter study","volume":"27","author":"Lee","year":"2013","journal-title":"Am J Rhinol Allergy"},{"key":"R17-20251230","doi-asserted-by":"crossref","first-page":"100540","DOI":"10.1016\/j.waojou.2021.100540","article-title":"Naso-ocular neuropeptide interactions in allergic rhinoconjunctivitis, rhinitis, and conjunctivitis","volume":"14","author":"Meng","year":"2021","journal-title":"World Allergy Organ J"},{"key":"R19-20251230","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1177\/19458924211041438","article-title":"Effect of medical therapy in allergic rhinitis: A systematic review and meta-analysis","volume":"36","author":"Zhang","year":"2022","journal-title":"Am J Rhinol Allergy"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1068_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:59:36Z","timestamp":1786647576000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1068_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_1068_25","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-06-13","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-14","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}