{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:34:54Z","timestamp":1787070894634,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Multiple sclerosis (MS) is considered the most prevalent neurological disorder in young adults with many patients manifesting sleep-related disorders (SRD) due to its pathomechanisms. This is subsequently reflected in patients\u2019 quality of life and physical activities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>This is a cross-sectional study at a tertiary care center. Patients diagnosed with MS were enrolled, and assessment of their sleep patterns and related disorders were measured using pre-validated scales. A questionnaire consisting of 38 items was used, and the obtained data were analyzed using RStudio software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 260 patients participated in the study. Most participants were aged 31\u201340 (n = 112) with a mean age of 36.49 \u00b1 8.41 (age range: 18\u201356 years). The most used medications were rituximab (27%) and ocrelizumab (25%). Shapiro\u2013Wilk Test was significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04) and just below the significance level of \u03b1 = 0.05, suggesting potential significant deviation in the distribution of age. Logistic regression model was applied, and the female probability of sleeping more than six hours was 3.60 times the probability of sleeping six hours or less.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Sleep quality is multifaceted and requires intensive investigation in patients with chronic disorders including MS. In this study, several novel data have been presented in a population that has very little literature data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_1114_24","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T04:02:19Z","timestamp":1731729739000},"page":"5306-5311","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Exploring sleep-related disorders in patients with multiple sclerosis: A questionnaire-based approach"],"prefix":"10.4103","volume":"13","author":[{"given":"Ahmed K.","family":"Bamaga","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Neuromuscular Medicine Unit, Faculty of Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awatif","family":"Aljohani","sequence":"additional","affiliation":[{"name":"Department of Neurology, King Fahad General Hospital, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama Y.","family":"Muthaffar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas S.","family":"Alyazidi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Y.","family":"Bahowarth","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouf A.","family":"Almasry","sequence":"additional","affiliation":[{"name":"Department of Neurology, King Fahad General Hospital, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danya Y.","family":"Bakhsh","sequence":"additional","affiliation":[{"name":"Department of Neurology, King Fahad General Hospital, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"R1-20250129","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/S1474-4422(10)70064-8","article-title":"The changing demographic pattern of multiple sclerosis epidemiology","volume":"9","author":"Koch-Henriksen","year":"2010","journal-title":"Lancet Neurol"},{"key":"R2-20250129","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1177\/014107680509800616","article-title":"Multiple sclerosis:The history of a disease","volume":"98","author":"Orrell","year":"2005","journal-title":"J R Soc Med"},{"key":"R3-20250129","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1001\/jamaneurol.2023.1135","article-title":"Population-based estimates for the prevalence of multiple sclerosis in the United States by race, ethnicity, age, sex, and geographic region","volume":"80","author":"Hittle","year":"2023","journal-title":"JAMA Neurol"},{"key":"R4-20250129","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/ana.24747","article-title":"Long-term evolution of multiple sclerosis disability in the treatment era","volume":"80","author":"Cree","year":"2016","journal-title":"Ann Neurol"},{"key":"R5-20250129","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jns.2010.12.008","article-title":"Sleep disorders and fatigue in multiple sclerosis:Evidence for association and interaction","volume":"302","author":"Kaminska","year":"2011","journal-title":"J Neurol Sci"},{"key":"R6-20250129","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jns.2011.07.015","article-title":"Sleep disturbances in multiple sclerosis","volume":"309","author":"Caminero","year":"2011","journal-title":"J Neurol Sci"},{"key":"R7-20250129","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1177\/1352458508092807","article-title":"Prevalence of sleep problems in individuals with multiple sclerosis","volume":"14","author":"Bamer","year":"2008","journal-title":"Mult Scler"},{"key":"R8-20250129","doi-asserted-by":"crossref","first-page":"995","DOI":"10.2165\/00023210-200721120-00004","article-title":"Role of the melatonin system in the control of sleep:Therapeutic implications","volume":"21","author":"Pandi-Perumal","year":"2007","journal-title":"CNS Drugs"},{"key":"R9-20250129","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0006-3223(89)90178-9","article-title":"Circadian rhythms of melatonin and cortisol in aging","volume":"25","author":"Sharma","year":"1989","journal-title":"Biol. 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