{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:20:18Z","timestamp":1787772018674,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>The AST\/platelet ratio index (APRI) is a well-researched indicator of liver fibrosis. Some studies have shown that APRI can be used as a predictor of severe dengue, but the data is limited. As dengue epidemics are common in our country with limited healthcare resources, we believe APRI can help emergency physicians\/primary physicians in predicting the severity of dengue and plan for the appropriate use of limited healthcare resources.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>1) To determine the utility of APRI as a predictor of severe dengue. 2) To determine the association of APRI with length of hospital stay and platelet requirement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A retrospective cross-sectional study was done on patients presented to the Emergency Medicine department at Travancore Medicity Medical College with a positive Dengue NS1 antigen or IgM antibody.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We found from the univariate analysis results that ALT &gt; 74.5 IU\/L has a sensitivity of 59.6 and a specificity of 76.3 (AUC: 0.696; 95% CI: 0.606\u20130.786), AST &gt; 160.5 IU\/L has a sensitivity of 42.3 and a specificity of 93.7 (AUC: 0.747; 95% CI: 0.665\u20130.829), and APRI &gt; 3.2 has a sensitivity of 69.2 and a specificity of 84.2 (AUC: 0.806; 95% CI: 0.72\u20130.884) to predict severe dengue. Patients with an APRI of &gt;3.2 required a mean hospital stay of 5.47 days (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.005); 27 (81.8%) requiring platelet transfusion had an APRI of &gt; 3.2 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.00).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>APRI is a straightforward index that can be easily derived from AST and platelet values. APRI values of &gt;3.2 can predict severe dengue with a sensitivity of 69.2 and a specificity of 84.2. APRI values of &gt;3.2 are also associated with the length of hospital stay and requirement of platelet transfusion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_1127_23","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T11:14:45Z","timestamp":1709637285000},"page":"613-618","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["APRI as a predictor of severe dengue fever"],"prefix":"10.4103","volume":"13","author":[{"given":"Ajith K.","family":"Jayachandran","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Travancore Medical College, Kollam, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincy","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Travancore Medical College, Kollam, Kerala, 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