{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:40:52Z","timestamp":1786653652869,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The present study aimed to compare clinical features, management, and outcomes between children and adolescents admitted as cases of multi-system inflammatory syndrome in children (MIS-C) in Indira Gandhi Medical College (IGMC), Shimla.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>We conducted a cross-sectional study for MIS-C from January to July 2021, in the pediatric ward of IGMC in Himachal Pradesh. All children admitted with a diagnosis of MIS-C were included in the study. Data regarding socio-demographic factors, clinical features, and treatment modalities were extracted and analyzed using Epi Info V7 software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 31 children diagnosed as cases of MIS-C were included. The mean age was 7.12 \u00b1 4.78 years. 71% were in group 0\u201310 years, followed by 29% in 11\u201318 years. Although the duration of hospital stay, mortality, and Kawasaki disease cases were more in children as compared to adolescents, the difference was not significant. Similarly, fever, rash, cough, hematemesis, tachypnea, respiratory distress, hypotension, vomiting, bleeding diathesis, hematuria, seizure, encephalopathy, hepatomegaly, splenomegaly, and lymphadenopathy were greater in children as compared to adolescents but were not significant. Likewise, abnormalities in various biochemical, hematological, inflammatory, and cardiac markers were deranged to a greater extent in children as compared to adolescents, but there was no significant difference. The need for various treatment modalities such as IVIG, methylprednisolone, low-molecular weight heparin, aspirin, respiratory Support, O\n                      <jats:sub>2<\/jats:sub>\n                      , ventilatory support, and inotropic support was more in children as compared to an adolescent, but there was no significant difference.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There was no significant difference in socio-demographic factors, clinical presentation, diagnostic test, mode of treatment, duration of stay, and mortality among children and adolescents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_1248_22","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T03:51:56Z","timestamp":1675050716000},"page":"7824-7829","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of clinical features, management, and outcomes between children and adolescents diagnosed with multi-system inflammatory syndrome in children"],"prefix":"10.4103","volume":"11","author":[{"given":"Pancham","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Sharma","sequence":"additional","affiliation":[{"name":"Medical College, Solan, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambika","family":"Sood","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanya","family":"Sharma","sequence":"additional","affiliation":[{"name":"Medical College, Mandi, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"R1-20260204","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1056\/NEJMoa2021680","article-title":"Multisystem inflammatory syndrome in U. S. children and adolescents","volume":"383","author":"Leora","year":"2020","journal-title":"N Engl J Med"},{"key":"R5-20260204","doi-asserted-by":"crossref","first-page":"fmaa127","DOI":"10.1093\/tropej\/fmaa127","article-title":"Unusual clinical manifestations and outcome of multisystem inflammatory syndrome in children (MIS-C) in a tertiary care hospital of North India","volume":"67","author":"Gupta","year":"2021","journal-title":"J Trop Pediatr"},{"key":"R6-20260204","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1001\/jamapediatrics.2021.0630","article-title":"Trends in geographic and temporal distribution of US children with multisystem inflammatory syndrome during the COVID-19 pandemic","volume":"175","author":"Belay","year":"2021","journal-title":"JAMA Pediatr"},{"key":"R7-20260204","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1007\/s00431-021-03993-5","article-title":"Multisystem inflammatory syndrome in children related to COVID-19: A systematic review","volume":"180","author":"Hoste","year":"2021","journal-title":"Eur J Pediatr"},{"key":"R9-20260204","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1007\/s00431-021-03993-5","article-title":"Multisysteminflammatory syndrome in children related to COVID-19: A systematic review","volume":"180","author":"Hoste","year":"2021","journal-title":"Eur J Pediatr"},{"key":"R10-20260204","doi-asserted-by":"crossref","first-page":"594127","DOI":"10.3389\/fped.2020.594127","article-title":"Case report: Case series of children with multisystem inflammatory syndrome following SARS-CoV-2 infection in Switzerland","volume":"8","author":"Fouriki","year":"2021","journal-title":"Front. Pediatr"},{"key":"R11-20260204","first-page":"1074","article-title":"Characteristics and outcomes of US children and adolescents with multisystem inflammatory syndrome in children (MIS-C) compared with severe acute COVID-19 JAMA","volume":"325","author":"Leora","year":"2021"},{"key":"R12-20260204","doi-asserted-by":"crossref","first-page":"100527","DOI":"10.1016\/j.eclinm.2020.100527","article-title":"Multisystem inflammatory syndrome in children: A systematic review","volume":"26","author":"Ahmed","year":"2020","journal-title":"EClinicalMedicine"},{"key":"R13-20260204","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1001\/jama.2021.2091","article-title":"Characteristics and outcomes of US children and adolescents with multisystem inflammatory syndrome in children (MIS-C) compared with severe acute COVID-19","volume":"325","author":"Feldstein","year":"2021","journal-title":"JAMA"},{"key":"R14-20260204","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3345\/cep.2020.01900","article-title":"Clinical features, diagnosis, and outcomes of multisystem inflammatory syndrome in children associated with coronavirus disease 2019","volume":"64","author":"Kwak","year":"2021","journal-title":"Clin Exp Pediatr"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1248_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:40:30Z","timestamp":1786650030000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1248_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":10,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_1248_22","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"2022-06-12","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-27","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}