{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:38:46Z","timestamp":1786649926250,"version":"build-2736575974"},"reference-count":5,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>A 49-year-old lady, hypertensive with dyslipidaemia, had thalamic bleed with intracranial multiple micro-haemorrhages. An extensive search was done and vasculitis was ruled out in the patient. Henceforth, she remained strict with medications and maintained blood pressure and lipids under control. After a lucid interval of 3 years, she attended emergency with complex partial seizure. We detected extensive microbleeds (significant increment) in magnetic resonance imaging of the brain and periventricular ischemic changes. A cerebrospinal fluid study and digital subtraction angiography of the brain were consistent with primary central nervous system (CNS) vasculitis (small vessel). She improved and currently is well on follow-up with immunosuppressive therapy. Interesting learning part in our case was late presentation of the patient with primary CNS vasculitis after a latency. It implies requirement of strong suspicion and stringent follow-up in these types of patients.<\/jats:p>","DOI":"10.4103\/jfmpc.jfmpc_1268_22","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T07:25:32Z","timestamp":1671607532000},"page":"7445-7447","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Vessel wall calcification and vascular event: Are we concerned enough?"],"prefix":"10.4103","volume":"11","author":[{"given":"Debabrata","family":"Chakraborty","sequence":"first","affiliation":[{"name":"Department of Neurology, Apollo Multispeciality Hospitals, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamashis","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Apollo Multispeciality Hospitals, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sankha S.","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Apollo Multispeciality Hospitals, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramanick","family":"Gobinda","sequence":"additional","affiliation":[{"name":"Department of Radiology, Apollo Multispeciality Hospitals, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushan","family":"Mukhopadhayay","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Apollo Multispeciality Hospitals, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"key":"R1-20260109","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1177\/17474930211065917","article-title":"World Stroke Organization (WSO):Global stroke fact sheet 2022","volume":"17","author":"Feigin","year":"2022","journal-title":"Int J Stroke"},{"key":"R2-20260109","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.tcm.2012.07.002","article-title":"Genetic pathways of vascular calcification","volume":"22","author":"Hofmann","year":"2012","journal-title":"Trends Cardiovasc Med"},{"key":"R3-20260109","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.jacc.2006.04.089","article-title":"Coronary artery calcification and myocardial perfusion in asymptomatic adults:The MESA (Multi-Ethnic Study of Atherosclerosis)","volume":"48","author":"Wang","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"R4-20260109","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1161\/CIRCULATIONAHA.107.743161","article-title":"Demer and yin tintut. Vascular calcification:Pathobiology of a multifaceted disease","volume":"117","author":"Linda","year":"2008","journal-title":"Circulation"},{"key":"R5-20260109","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00223-013-9712-z","article-title":"Vascular calcification:An update on mechanisms and challenges in treatment","volume":"93","author":"Wu","year":"2013","journal-title":"Calcif Tissue Int"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1268_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:00:04Z","timestamp":1786647604000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1268_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":5,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_1268_22","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"2022-06-15","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-16","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}