{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:00:43Z","timestamp":1787169643081,"version":"build-2736575974"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>Systemic lupus erythematosus (SLE) is an autoimmune disease associated with several autoantibodies targeted to nuclear and cytoplasmic antigens. Positivity of the serum antinuclear antibody (ANA), double stranded (ds) DNA, anti-smith (sm) antibody are essential for the diagnosis of SLE. Anti-histone antibody is usually present in drug-induced SLE. Autoimmune hemolytic anemia (AIHA) in SLE is usually mediated by warm IgG anti-erythrocyte antibodies. Our case evaluation revealed negative anti-ds antibody and anti-smith antibody, low C3 and C4 complement level, strong anti-histone antibody-positive status, and AIHA. She responded with intravenous methyl prednisolone and showed significant clinical improvement. Anti-histone antibody-positive SLE presenting with AIHA is rare, probably we are reporting the first case.<\/jats:p>","DOI":"10.4103\/jfmpc.jfmpc_1324_21","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T01:12:59Z","timestamp":1648516379000},"page":"1542-1544","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["An unusual association between anti-histone antibody seropositive SLE, autoimmune hemolytic anemia, and herpetic rash: A case report"],"prefix":"10.4103","volume":"11","author":[{"given":"Ajay Kumar","family":"Jha","sequence":"first","affiliation":[{"name":"Department of Medicine, Tata Main Hospital, Jamshedpur, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Sunder","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tata Main Hospital, Jamshedpur, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,3,18]]},"reference":[{"key":"B1-20240828","first-page":"2515","volume":"2","year":"2018","journal-title":"Harrison's Principle of Internal Medicine"},{"key":"B2-20240828","doi-asserted-by":"crossref","first-page":"bcr2013009337","DOI":"10.1136\/bcr-2013-009337","article-title":"Cold agglutinin-induced haemolysis in association with antinuclear antibody-negative SLE","volume":"2013","author":"Chaubey","year":"2013","journal-title":"BMJ Case Rep"},{"key":"B3-20240828","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1191\/0961203304lu2025oa","article-title":"Review of ACR hematologic criteria in systemic lupus erythematosus","volume":"2013","author":"Kao","year":"2004","journal-title":"Lupus"},{"key":"B4-20240828","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1024\/0040-5930.62.5.292","article-title":"Systemic lupus erythematosus\u2014myths and dogma","volume":"62","author":"Schifferli","year":"2005","journal-title":"Ther Umsch"},{"key":"B5-20240828","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/rheumatology\/keg069","article-title":"Prevalence, patterns of disease and outcome in patients with systemic lupus erythematosus who develop severe haematological problems","volume":"42","author":"Sultan","year":"2003","journal-title":"Rheumatology (Oxford)"},{"key":"B6-20240828","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0268-960X(93)90006-P","article-title":"Haematological manifestations of systemic lupus erythematosus","volume":"2013","author":"Keeling","year":"1993","journal-title":"Blood Rev"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1324_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:10:50Z","timestamp":1787166650000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1324_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,18]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_1324_21","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,18]]},"assertion":[{"value":"2021-07-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-20","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}