{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:24:45Z","timestamp":1787757885383,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Monomelic amyotrophy (MMA) is a benign, rare, sporadic disorder of adolescent and young adults with male predominance, where neurogenic amyotrophy is restricted to an upper or lower limb. It is a variant of lower motor neuron disorder with insidious onset and slow progression for 2-4 years. Paucity of cohort studies as well as relative unawareness among physicians in eastern India stimulated us to do this work.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>Prospective observational study involving 140 cases of MMA from 2012 to 2016, conducted at S.C.B.Medical College, cuttack, Odisha to evaluate clinical profile, electrophysiology and radiological features. All the data were analysed &amp; subjected to statistical analysis through SPSS software version 24.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Mean age at onset and presentation were 19.6yrs and 21.7yrs respectively and the average duration 3.2yrs. Upper limb involvement was more common (91.4%) with distal affection (83%) more than proximal (7%). Isolated Leg amyotrophy found in 12 cases (~9%) and 10 cases were having thigh weakness &amp; atrophy. B\/L Upper Limb distal involvement was present in 18.5% cases asymmetrically. Family history found in~2.8%. Autonomic symptoms were present in affected and bilateral homologous Limb in 21%, 5.8%(~6%) patients. Changes in electromyography (EMG) were present in affected limb (100%) and clinically unaffected limb (15%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>MMA is a benign disease of young males with weakness and atrophy confined to unilateral limb or asymmetrical homologous limb and areflexia without sensory loss. It progresses variably for 2-3 years followed by stabilization without progression to Motor neuron disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_1340_21","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T07:41:10Z","timestamp":1653464470000},"page":"1740-1744","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Monomelic amyotrophy with clinico-radiological and electrophysiological evaluation"],"prefix":"10.4103","volume":"11","author":[{"given":"Maheswar","family":"Samanta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manasi","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok Kumar","family":"Mallick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kali Prasanna","family":"Swain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhankar","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-22-20240828","first-page":"2190","article-title":"Juvenile muscular atrophy of unilateral upper extremity:A new clinical entity","volume":"61","author":"Hirayama","year":"1959","journal-title":"Psychiatr Neurol Jpn"},{"key":"R2-22-20240828","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1001\/archneur.1984.04050160050015","article-title":"Monomelicamyotrophy","volume":"41","author":"Gourie-Devi","year":"1984","journal-title":"Arch Neurol"},{"key":"R3-22-20240828","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0303-8467(81)80005-4","article-title":"Wasted Leg Syndrome:A clinical, electrophysiological and histopathological study","volume":"83","author":"Prabhakar","year":"1981","journal-title":"Clin Neurol Neurosurgery"},{"key":"R4-22-20240828","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0072-9752(07)80014-5","article-title":"Monomelicamyotrophy of upper or lower limbs","volume":"82","author":"Gourie-Devi","year":"2007","journal-title":"Hand Book of Clinical Neurology"},{"key":"R5-22-20240828","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3109\/21678421.2014.903976","article-title":"Monomelic amyotrophy:Clinical profile and natural history of 279 cases seen over five years (1976-2010)","volume":"15","author":"Nalini","year":"2014","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"R6-22-20240828","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1590\/S0004-282X2000000500003","article-title":"Benign monomelicamyotrophy:A study of twenty-one cases","volume":"58","author":"Freitas","year":"2000","journal-title":"Arq Neuropsiquiatr"},{"key":"R7-22-20240828","first-page":"363","article-title":"Widespread electromyographic abnormalities in patients with monomelicamyotrophy:A detailed EMG study","volume":"45","author":"Khandelwal","year":"2005","journal-title":"Electromyogr Clin Neurophysiol"},{"key":"R8-22-20240828","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1034\/j.1600-0404.2003.02142.x","article-title":"Long termfollow-up of 44 patients with Brachial monomelic amyotrophy","volume":"107","author":"Gourie-Devi","year":"2003","journal-title":"Acta Nerol Scand"},{"key":"R9-22-20240828","first-page":"478516","article-title":"Review article, nosology of juvenile muscular atrophy of distal upper extremity:From monomelicamyotrophy to Hirayama disease- Indian perspective","volume":"2013","author":"Maqbool","year":"2013","journal-title":"Biomed Res Int"},{"key":"R10-22-20240828","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3346\/jkms.1994.9.2.145","article-title":"A clinical study of benign focal amyotrophy","volume":"9","author":"Kim","year":"1994","journal-title":"J Korean Med Sci"},{"key":"R11-22-20240828","doi-asserted-by":"crossref","first-page":"e02073","DOI":"10.1002\/brb3.2073","article-title":"Benign monomelic amyotrophy of lower limb in a cohort of Chinese patients","volume":"11","author":"Wang","year":"2021","journal-title":"Brain Behav"},{"key":"R12-22-20240828","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1016\/j.clinph.2021.02.036","article-title":"Symposium 3: Motor neuron disease SY3. 1. Monomelic amyotrophy\u2013experience from a large cohort","volume":"132","author":"Nalini","year":"2021","journal-title":"Clin Neurophysiol"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1340_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:56:06Z","timestamp":1787756166000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1340_21"}},"subtitle":["A study from Eastern India"],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_1340_21","relation":{},"ISSN":["2249-4863"],"issn-type":[{"value":"2249-4863","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]}}}