{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:02:42Z","timestamp":1787169762592,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Spontaneous pneumomediastinum is an uncommon complication of Corona Virus Disease (COVID)-19 presenting mostly in moderate to severe cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This is a retrospective observational imaging and hospital data-based study done on 15 confirmed patients of COVID-19 who underwent high resolution computed tomography (HRCT) thorax at the Department of Radio-Diagnosis of a tertiary medical center in the Himalayan foothills. The clinico-radiological profile of the study group was assessed and it was aimed at finding the association of pneumomediastinum with the severity of lung changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A strong association of pneumomediastinum was observed with severe lung changes on HRCT thorax (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 13, 87%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.00001). Dyspnea was the most common presenting factor. The mortality rate is high in mechanically intubated patients of pneumomediastinum with COVID-19 (75%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Pneumomediastinum is a complication of a severe COVID-19 disease spectrum. Along with severe lung parenchymal disease, systemic inflammation, systemic steroid therapy, comorbid state, and mechanical intubation, it is a part of the pool of poor prognostic factors. HRCT is essential for making a quick and comprehensive diagnosis, thereby, guiding the clinician for further management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_1346_21","type":"journal-article","created":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T11:54:47Z","timestamp":1645876487000},"page":"537-541","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Pneumomediastinum: Radiological profile and associations of uncommon complication of COVID-19"],"prefix":"10.4103","volume":"11","author":[{"given":"Prashant","family":"Sarda","sequence":"first","affiliation":[{"name":"Department of Radiodiagnosis, SGRRIM and HS, Dehradun, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Thakker","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, SGRRIM and HS, Dehradun, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Premila D.","family":"Waikhom","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, SGRRIM and HS, Dehradun, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manali","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, SGRRIM and HS, Dehradun, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, SGRRIM and HS, Dehradun, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sovinder","family":"Baisoya","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, SGRRIM and HS, Dehradun, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagdish","family":"Rawat","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, SGRRIM and HS, Dehradun, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv K.","family":"Azad","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, SGRRIM and HS, Dehradun, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,2,16]]},"reference":[{"key":"B1-20240828","doi-asserted-by":"crossref","first-page":"e00806","DOI":"10.1016\/j.idcr.2020.e00806","article-title":"Spontaneous pneumomediastinum occurring in the SARS-COV-2 infection","volume":"21","author":"Kolani","year":"2020","journal-title":"IDCases"},{"key":"B2-20240828","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1089\/lap.2020.0692","article-title":"Clinical characteristics and outcome of 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