{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:01:13Z","timestamp":1787169673357,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To describe the clinical pattern of invasive fungal sinusitis in COVID-19 and post-COVID-19 cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>All patients affected by COVID-19 or having a history of COVID-19 infection with an invasive fungal lesion (mucormycosis\/aspergillosis) of the paranasal sinuses, orbit, palate, brain, lung, skin\/cheek, and dental has been evaluated for possible description in tertiary care hospital in May 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twenty-four patients presented with clinical signs and symptoms of fungal infection with a history of COVID-19. Paranasal sinuses were involved in all patients. Palatal involvement was seen in seven cases. Intraorbital extension was seen in 13 cases. Intracerebral involvement was seen in three cases. Comorbid type 2 diabetes was seen in 20 patients. The use of steroids was noticed in 16 cases. Our observation revealed that uncontrolled diabetes, overuse of steroids, increased ferritin levels, and low hemoglobin percentage are the main factors aggravating mucormycosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_1352_21","type":"journal-article","created":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T11:54:47Z","timestamp":1645876487000},"page":"807-811","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Epidemic in pandemic: Fungal sinusitis in COVID-19"],"prefix":"10.4103","volume":"11","author":[{"given":"Ripu Daman","family":"Arora","sequence":"first","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, AIIMS, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin M.","family":"Nagarkar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, AIIMS, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. S. B. S. Krishna","family":"Sasanka","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, AIIMS, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pugazhenthan","family":"Thangaraju","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, AIIMS, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupa","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, AIIMS, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish S.","family":"Satpute","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, AIIMS, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmistha","family":"Chakravarty","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, AIIMS, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Keche","sequence":"additional","affiliation":[{"name":"Department of Microbiology, AIIMS, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aakash","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, AIIMS, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sree Sudha","family":"TY","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, AIIMS, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,2,16]]},"reference":[{"key":"B2-20240828","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1001\/jamaoto.2020.1922","article-title":"SARS-CoV-2 virus isolated from the mastoid and middle ear:Implications for COVID-19 precautions during ear surgery","volume":"146","author":"Frazier","year":"2020","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"B3-20240828","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0030-6665(00)80002-X","article-title":"Definitions of fungal rhinosinusitis","volume":"33","author":"Ferguson","year":"2000","journal-title":"Otolaryngol Clin North Am"},{"key":"B4-20240828","first-page":"13236","article-title":"Zygomycetes in human disease","author":"Ribes","year":"2000","journal-title":"Clin Microbiol Rev"},{"key":"B5-20240828","first-page":"76","article-title":"Attachment of spores of the human pathogenic fungus Rhizopus oryzaeto extracellular matrix components","volume":"70","author":"Bouchara","year":"1996","journal-title":"Eur J Cell Biol"},{"key":"B6-20240828","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.anl.2009.09.001","article-title":"Emerging therapeutic options in fulminant invasive rhinocerebral mucormycosis","volume":"37","author":"Scheckenbach","year":"2010","journal-title":"Auris Nasus Larynx"},{"key":"B7-20240828","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1439-0507.2007.01364.x","article-title":"Rhinocerebral mucormycosis:The disease spectrum in 27 patients","volume":"50","author":"Mohindra","year":"2007","journal-title":"Mycoses"},{"key":"B8-20240828","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1056\/NEJM199707243370407","article-title":"Fungal sinusitis","volume":"337","author":"DeShazo","year":"1997","journal-title":"N Engl J Med"},{"key":"B9-20240828","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0030-6665(00)80008-0","article-title":"Analgorithmic approach to the diagnosisand management of invasive fungal rhinosinusitis in the immunocompromised patient","volume":"33","author":"Gillespie","year":"2000","journal-title":"Otolaryngol Clin North Am"},{"key":"B10-20240828","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/BF01932420","article-title":"Mycosismucorina","volume":"102","author":"Paltauf","year":"1885","journal-title":"Virchows Arch Pathol Anat Physiol Klin Med"},{"key":"B11-20240828","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.jinf.2020.02.016","article-title":"Clinicalcharacter- istics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19):A multi-center study in Wenzhou city, Zhejiang, China","volume":"80","author":"Yang","year":"2020","journal-title":"J Infect"},{"key":"B12-20240828","article-title":"Dexamethasone in hospitalised patients with COVID-19:preliminary report","author":"Peter","year":"2020","journal-title":"N Eng J Med"},{"key":"B13-20240828","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/ki.1994.89","article-title":"Deferoxamine augmentsgrowth and pathogenicity of Rhizopus, while hydroxypyridinone chelators have no effect","volume":"45","author":"Boelaert","year":"1994","journal-title":"Kidney Int"},{"key":"B14-20240828","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.2337\/diacare.31.12.1109","article-title":"A mechanism of susceptibility to mucormycosisin diabetic ketoacidosis:Transferrin and iron availability","volume":"31","author":"Artis","year":"1982","journal-title":"Diabetes"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1352_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:11:31Z","timestamp":1787166691000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1352_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_1352_21","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"2021-07-08","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-16","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}