{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:36:41Z","timestamp":1787773001050,"version":"build-2784847793"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Human immunodeficiency virus (HIV) and malaria infections are among the major public health concerns in sub-Saharan Africa, where they are associated with high morbidity and mortality. The study was conducted to assess the occurrence and clinical features of HIV and malaria in co-infected individuals in Osun State, Nigeria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      The study was cross-sectional, which involved 422 participants who were administered structured questionnaires for socio-demographic and clinical data. Venous blood was collected for malaria parasite detection and count from One hundred and seventy-four HIV seropositive individuals. They were re-examined clinically for HIV diagnosis, CD\n                      <jats:sub>4<\/jats:sub>\n                      <jats:sup>+<\/jats:sup>\n                      T cell counts, and packed cell volume (PCV).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean age of the participants was 28.48 \u00b1 15.38 while the overall predominance of malaria among the HIV-positive patients was 11.5% (20\/174). The malaria prevalence was significantly higher in female patients (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0088) and occupational status among students (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0001). Malaria\/HIV co-infected patients had a significantly lower mean value of PCV (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0001), CD\n                      <jats:sub>4<\/jats:sub>\n                      <jats:sup>+<\/jats:sup>\n                      cell count (0.0001), and temperature (0.0001) compared to HIV-infected patients having no malaria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      The study showed that females had relatively higher malaria infection compared to their male counterparts. To achieve better management of HIV patients against malaria infection, proper preventive measures, antiretroviral therapy (ART), and chemoprophylaxis are a useful strategy to put in place. Also, the monitoring of CD\n                      <jats:sub>4<\/jats:sub>\n                      <jats:sup>+<\/jats:sup>\n                      cell count, viral load, and some hematology indices on a regular basis is crucial.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_1361_21","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T07:34:07Z","timestamp":1666164847000},"page":"5332-5339","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Occurrence and clinical features of HIV and malaria in co-infected individuals in Osun State, Nigeria"],"prefix":"10.4103","volume":"11","author":[{"given":"Oyeniran O.","family":"Adeola","sequence":"first","affiliation":[{"name":"Department of Pure and Applied Biology (Microbiology Unit), Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oladipo E.","family":"Kolawole","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Laboratory of Molecular Biology and Bioinformatics, Adeleke University, Ede, Osun State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abiodun F.","family":"Yemi","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, Ambrose Ali University, Ekpoma, Edo State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awoyelu E.","family":"Hilda","sequence":"additional","affiliation":[{"name":"Department of Physiology, Obafemi Awolowo University, Ile-ife, Osun State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adu T.","family":"Samson","sequence":"additional","affiliation":[{"name":"Department of Physiology, Obafemi Awolowo University, Ile-ife, Osun State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oloke J.","family":"Kola","sequence":"additional","affiliation":[{"name":"Department of Pure and Applied Biology (Microbiology Unit), Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria"},{"name":"Department of Natural Sciences (Microbiology), Precious Cornerstone University, Ibadan, Oyo State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,10,14]]},"reference":[{"key":"B2-20240828","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1756-3305-6-18","article-title":"Effect of malaria on HIV\/AIDS transmission and progression","volume":"6","author":"Alemu","year":"2013","journal-title":"Parasit Vectors"},{"key":"B4-20240828","doi-asserted-by":"crossref","first-page":"e0206907","DOI":"10.1371\/journal.pone.0206907","article-title":"Discontinuing cotrimoxazole preventive therapy in HIV-infected adults who are stable 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