{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:38:54Z","timestamp":1786653534265,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>\n                    In India, it is estimated that 10\u201324 million people are living with active HCV infection, with a seroprevalence of 0.09% to 2.02% among the healthy population. The current study evaluates the efficacy of newer pan-genotypic directly acting antiviral drugs for SVR, which is the hallmark of successful HCV therapy. Data were collected on the prevalence of HCV infection, rates of SVR, and associated risk factors. In univariate analysis, serum albumin, AST, and APRI are significant predictors of SVR with\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05. Specifically, a unit increase in serum albumin doubled the chances of achieving SVR (OR: 2.08, CI: 1.02\u20134.19), while increases in AST and APRI values were associated with reduced chances of SVR (OR: -0.99, CI: 0.98\u20130.99; OR: -0.79, CI: 0.64\u20130.98). Non-cirrhotic patients were significantly more likely to achieve SVR compared to decompensated cirrhotic patients (OR: 6.48, CI: 1.46\u201328.59). In the multivariable logistic regression analysis, taking all variables with a P value &lt; 0.05 in the univariate analysis, such an association was not found, and it established the multifactorial nature of SVR. The present study underlines the importance of early diagnosis and the effectiveness of antiviral drugs against improved treatment outcomes of HCV patients in India. The findings present the challenges and successes in HCV elimination in a diverse and populous country.\n                  <\/jats:p>","DOI":"10.4103\/jfmpc.jfmpc_1379_24","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T04:06:21Z","timestamp":1742789181000},"page":"942-946","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Sustained virological response in HCV patients receiving antiviral treatment at a teaching centre of northern India"],"prefix":"10.4103","volume":"14","author":[{"family":"Astha","sequence":"first","affiliation":[{"name":"Department of Microbiology, F.H. Medical College, Agra, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arti","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayushi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Liberal Arts and Humanities, Jindal School of Liberal Arts and Humanities, Jindal Global University, Sonipat, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Sahu","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, ASMC, Auraiya, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharmendra","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of ENT, ASMC, Auraiya, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pragya","family":"Shakya","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"issue":"2","key":"R1-20250325","first-page":"1","article-title":"Recent trends in chronic hepatitis C virus treatment","volume":"2","author":"Sally","year":"2018","journal-title":"Med J Viral Hepat"},{"key":"R2-20250325","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.4254\/wjh.v7.i10.1377","article-title":"Hepatitis C virus:Virology, diagnosis and treatment","volume":"7","author":"Li","year":"2015","journal-title":"World J Hepatol"},{"key":"R3-20250325","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.18203\/2394-6040.ijcmph20212022","article-title":"Community-based transmission of hepatitis C in India:A systematic review","volume":"8","author":"Husain","year":"2021","journal-title":"Int J Community Med Public Health"},{"key":"R5-20250325","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.3390\/diagnostics12051255","article-title":"Diagnostic accuracy of point-of-care HCV Viral load assays for HCV diagnosis:A systematic review and meta-analysis","volume":"12","author":"Tang","year":"2022","journal-title":"Diagnostics"},{"key":"R6-20250325","doi-asserted-by":"crossref","first-page":"S114","DOI":"10.1002\/hep.1840360715","article-title":"Introduction to therapy of hepatitis C","volume":"36","author":"Lindsay","year":"2002","journal-title":"Hepatology"},{"key":"R7-20250325","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/cld.1014","article-title":"Histological grading and staging of chronic hepatitis","volume":"17","author":"Krishna","year":"2021","journal-title":"Clin Liver Dis"},{"key":"R8-20250325","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/cld.1137","article-title":"Hepatitis C virus in India:Challenges and successes","volume":"18","author":"Anand","year":"2021","journal-title":"Clin Liver Dis (Hoboken)"},{"key":"R9-20250325","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2147\/HMER.S62014","article-title":"Daclatasvir-sofosbuvir combination therapy with or without ribavirin for hepatitis C virus infection:From the clinical trials to real life","volume":"8","author":"Pol","year":"2016","journal-title":"Hepat Med"},{"key":"R10-20250325","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.jhep.2015.06.003","article-title":"HCV targeting of patients with cirrhosis","volume":"63","author":"Ferenci","year":"2015","journal-title":"J Hepatol"},{"key":"R11-20250325","doi-asserted-by":"crossref","first-page":"204","DOI":"10.21608\/mjmr.2022.217944","article-title":"Predictors of sustained virological response in chronic hepatitis C patients treated with current direct acting antiviral drugs","volume":"31","author":"Soliman","year":"2020","journal-title":"Minia J Med Res"},{"key":"R12-20250325","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.idc.2017.07.014","article-title":"Hepatitis C virus infection in the older patient","volume":"31","author":"Reid","year":"2017","journal-title":"Infect Dis Clin North Am"},{"key":"R13-20250325","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.3390\/jpm12091517","article-title":"Direct-acting antivirals for HCV treatment in decompensated liver cirrhosis patients:A systematic review and meta-analysis","volume":"12","author":"An","year":"2022","journal-title":"J Pers Med"},{"key":"R14-20250325","first-page":"144","article-title":"Efficacy and safety of sofosbuvir-based regimens in hepatitis C patients with decompensated cirrhosis:A systematic review and meta-analysis","volume":"11","author":"Zhang","year":"2023","journal-title":"J Clin Transl Hepatol"},{"key":"R15-20250325","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12876-019-0973-5","article-title":"Rapid decline of noninvasive fibrosis index values in patients with hepatitis C receiving treatment with direct-acting antiviral agents","volume":"19","author":"Hsu","year":"2019","journal-title":"BMC Gastroenterol"},{"key":"R16-20250325","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3892\/etm.2020.9531","article-title":"Dynamics of APRI and FIB-4 in HCV cirrhotic patients who achieved SVR after DAA therapy","volume":"21","author":"Leu\u015ftean","year":"2021","journal-title":"Exp Ther Med"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1379_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:39:03Z","timestamp":1786649943000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1379_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_1379_24","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-08-09","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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