{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:27:43Z","timestamp":1786739263186,"version":"build-2736575974"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Early diagnosis of neonatal sepsis is very essential part of newborn care to prevent mortality and decrease morbidity in newborns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The aim of this study is to correlate an increase in C-reactive protein (CRP) titre and a decrease in platelet count with an increased incidence of neonatal septicemia, for an effective subtle approach in neonatal septicemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A retrospective study was conducted in the neonatal intensive care unit (NICU) of a tertiary care hospital from Jan 2022 to July 2023. Neonates admitted to the NICU with suspected sepsis were screened for sepsis. Screening was done by taking blood culture samples before administration of antibiotics, serum samples for CRP and blood samples for platelet count.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result:<\/jats:title>\n                    <jats:p>A total of 270 newborns with suspected sepsis were included in the study. Blood culture positivity was seen in 27.7 (27\/75) cases. About 32.9% (89\/270) of the neonates with suspected sepsis and 61.3% (46\/75) neonates with confirmed sepsis had raised CRP; 32.2% (87\/270) neonates with suspected sepsis and 64% (48\/75) with confirmed sepsis had decreased platelet count. Both an increase in CRP and a decrease in platelets were seen in 61.3% (46\/75) of confirmed cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In our study, both raised CRP and decreased platelet count were seen in around 60% of confirmed cases of sepsis. So, CRP titre and platelet count can be used as early, rapid diagnostic markers for confirmed sepsis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_1390_23","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T06:08:07Z","timestamp":1718345287000},"page":"2233-2236","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["C-reactive protein and thrombocytopenia as essential early indicators: Subtle approach to neonatal sepsis"],"prefix":"10.4103","volume":"13","author":[{"given":"Ruchi","family":"Kotpal","sequence":"first","affiliation":[{"name":"Department of Microbiology, NCR Medical College, Meerut, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonal","family":"Jindal","sequence":"additional","affiliation":[{"name":"Department of Microbiology, LLRM Govt Medical College, Meerut, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"R1-20260204","doi-asserted-by":"crossref","first-page":"1092671","DOI":"10.3389\/fped.2023.1092671","article-title":"Risk factors for neonatal sepsis among neonates in the neonatal intensive care unit at Hawassa University Comprehensive Specialized Hospital and Adare General Hospital in Hawassa City, Ethiopia","volume":"11","author":"Shifera","year":"2023","journal-title":"Front Pediatr"},{"key":"R2-20260204","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1056\/NEJM200007203430310","article-title":"Neonatal group B streptococcal disease\u2014Screening and prevention","volume":"343","author":"Schuchat","year":"2000","journal-title":"N Engl J Med"},{"issue":"Suppl 2","key":"R3-20260204","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/S0378-3782(12)70019-1","article-title":"Early and late onset sepsis in very-low-birth-weight infants from a large group of neonatal intensive care units","volume":"88","author":"Hornik","year":"2012","journal-title":"Early Hum Dev"},{"issue":"4","key":"R4-20260204","doi-asserted-by":"crossref","first-page":"e0215683","DOI":"10.1371\/journal.pone.0215683","article-title":"Risk factors of neonatal sepsis in India: A systematic review and meta-analysis","volume":"14","author":"Murthy","year":"2019","journal-title":"PLoS One"},{"key":"R5-20260204","doi-asserted-by":"crossref","first-page":"F25","DOI":"10.1136\/fn.87.1.F25","article-title":"Blood cultures in newborns and children: Optimising an everyday test","volume":"87","author":"Buttery","year":"2002","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"R6-20260204","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/BF02727835","article-title":"Rapid diagnostic tests in neonatal septicemia","volume":"55","author":"Chandna","year":"1988","journal-title":"Indian J Pediatr"},{"key":"R7-20260204","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0022-3476(79)80096-7","article-title":"The neonatal blood count in health and disease. 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