{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:27:08Z","timestamp":1787758028499,"version":"build-2784847793"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Scrub typhus is a reemerging zoonosis, which presents as acute febrile illness. Very few paediatric prospective studies on this disease are reported from Eastern India. This prospective observational study was carried out to study the clinical presentation, diagnosis, complications and immediate outcome of Scrub typhus in paediatric population in a tertiary care hospital from Eastern India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>Totally 209 cases between 1 month and 18 years of age were included. Clinical manifestations, laboratory parameters and immediate outcome of all patients were recorded. All the data were collected and plotted in Microsoft Excel master chart. Continuous data were presented as mean \u00b1 standard deviation (SD) and categorical data as frequency and percentage. All the data analysis was performed using statistical software IBM Statistical Package for the Social Sciences (SPSS) version 20.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Highest number of cases (41.1%) were found between 1 year and 5 years age group. Fever was the presenting complaint in all cases. Other common symptoms were cough (34%), pain abdomen (23.4%), vomiting (23%), seizure (11.5%) and altered sensorium (9.6%). Hepatomegaly was found in 56.5% and splenomegaly in 39.7% cases. Eschar was found in 27.3% cases. C-reactive protein was elevated (&gt;10 mg\/L) in 93.3% children. Other complications were pneumonitis (20.6%), meningoencephalitis (12.4%), septic shock (8.6%), acute respiratory distress syndrome (5.7%), myocarditis (4.8%) and acute kidney injury (4.3%). Mortality was low (1%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Scrub typhus is not uncommon in paediatric population and it must be considered as a close differential diagnosis of any acute febrile illness even when classical clinical presentations are not found. Early treatment results in favourable outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_1464_21","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T10:17:00Z","timestamp":1656584220000},"page":"2503-2506","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Scrub Typhus in Paediatric Age Group at a Tertiary Care Centre of Eastern India: Clinical, Biochemical Profile and Complications"],"prefix":"10.4103","volume":"11","author":[{"given":"Aman","family":"Agrawal","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preetinanda","family":"Parida","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit Ranjan","family":"Rup","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibabratta","family":"Patnaik","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebaranjan","family":"Biswal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"B1-20240828","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1258\/td.2010.090508","article-title":"Scrub typhus in Southern India:Are we doing enough?","volume":"40","author":"Razak","year":"2010","journal-title":"Trop Doct"},{"key":"B2-20240828","doi-asserted-by":"crossref","first-page":"208","DOI":"10.7883\/yoken.JJID.2005.208","article-title":"Investigation of an outbreak of scrub typhus in the Himalayan region of India","volume":"58","author":"Sharma","year":"2005","journal-title":"Jpn J Infect Dis"},{"key":"B3-20240828","first-page":"24","article-title":"Outbreak of scrub typhus in Pondicherry","volume":"58","author":"Vivekanandan","year":"2010","journal-title":"J Assoc Physicians India"},{"key":"B4-20240828","first-page":"CD002150","article-title":"Antibiotics for treating scrub typhus","volume":"2018","author":"Liu","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"B5-20240828","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s13312-011-0141-7","article-title":"Rickettsial diseases in central India:Proposed clinical scoring system for early detection of spotted fever","volume":"48","author":"Rathi","year":"2011","journal-title":"Indian Pediatr"},{"key":"B6-20240828","article-title":"Scrub typhus in children:Jammu experience","author":"Digra","year":"2010","journal-title":"Jk Science"},{"key":"B7-20240828","first-page":"385","article-title":"Rickettsial infections seen in rural India","volume":"51","author":"Joshi","year":"2009","journal-title":"Bombay Hosp J"},{"key":"B8-20240828","doi-asserted-by":"crossref","first-page":"419","DOI":"10.4103\/mjdrdypu.mjdrdypu_236_18","article-title":"Epidemiological and clinical features of scrub typhus in Odisha, Eastern India","volume":"12","author":"Das","year":"2019","journal-title":"Med J Dr Patil Vidyapeeth"},{"key":"B9-20240828","first-page":"1","article-title":"Kidney disease:Improving global outcomes (KDIGO) acute kidney injury work group. 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