{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:23:20Z","timestamp":1787847800495,"version":"build-2784847793"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>Wernicke's encephalopathy (WE) is an acute neurological condition characterized by the triad of ophthalmoparesis with nystagmus, ataxia, and global confusion. WE is a life-threatening illness caused by thiamine deficiency, primarily affecting the peripheral and central nervous systems. Thiamine deficiency is predominantly associated with chronic alcoholism, but various other causes have also been reported, including severe malnutrition, prolonged parenteral nutrition, malignancies, immunodeficiency syndromes, liver disease, hyperthyroidism and severe anorexia nervosa, and hyperemesis gravidarum. We, hereby, report a unique case of WE induced by hyperemesis gravidarum that presented in mid-trimester of pregnancy in a rather extremely unusual way with focal seizures and secondary generalization but fortunately ended up with a good feto-maternal outcome.<\/jats:p>","DOI":"10.4103\/jfmpc.jfmpc_1466_20","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T09:31:56Z","timestamp":1611653516000},"page":"567-571","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Seizure as a presenting manifestation of Wernicke's encephalopathy induced by hyperemesis gravidarum"],"prefix":"10.4103","volume":"10","author":[{"given":"Ritwik","family":"Ghosh","sequence":"first","affiliation":[{"name":"Department of General Medicine, Burdwan Medical College & Hospital, Burdwan, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpan","family":"Mandal","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Burdwan Medical College & Hospital, Burdwan, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devlina","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of General Medicine-Infectious Disease and Beleghata General Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhankar","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrinal Kanti","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Burdwan Medical College & Hospital, Burdwan, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souvik","family":"Dubey","sequence":"additional","affiliation":[{"name":"Department of Neuromedicine, Bangur Institute of Neurosciences, Institute of Postgraduate Medical Education & Research and SSKM Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Durjoy","family":"Lahiri","sequence":"additional","affiliation":[{"name":"Department of Neuromedicine, Bangur Institute of Neurosciences, Institute of Postgraduate Medical Education & Research and SSKM Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Finsterer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Krankenanstalt Rudolfstiftung, Messerli Institute, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biman Kanti","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Neuromedicine, Bangur Institute of Neurosciences, Institute of Postgraduate Medical Education & Research and SSKM Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,1]]},"reference":[{"key":"R1-20260813","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.mayocp.2019.02.018","article-title":"Wernicke encephalopathy-clinical pearls","volume":"94","author":"Sinha","year":"2019","journal-title":"Mayo Clin Proc"},{"key":"R2-20260813","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1080\/1028415X.2017.1416941","article-title":"Recurrent Wernicke's encephalopathy in pregnancy: A case report","volume":"22","author":"Stephens","year":"2019","journal-title":"Nutr Neurosci"},{"key":"R3-20260813","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejogrb.2019.03.006","article-title":"Wernicke's encephalopathy in hyperemesis gravidarum: A systematic review","volume":"236","author":"Oudman","year":"2019","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"R4-20260813","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/j.1460-9568.2006.04651.x","article-title":"Gene expression changes in thalamus and inferior colliculus associated with inflammation, cellular stress, metabolism and structural damage in thiamine deficiency","volume":"23","author":"Vemuganti","year":"2006","journal-title":"Eur J Neurosci"},{"key":"R5-20260813","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/01.ogx.0000206336.08794.65","article-title":"Hyperemesis gravidarum complicated by Wernicke encephalopathy: Background, case report, and review of the literature","volume":"61","author":"Chiossi","year":"2006","journal-title":"Obstet Gynecol Surv"},{"key":"R6-20260813","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1007\/s11011-017-0106-1","article-title":"Epileptic seizures in nonalcoholic Wernicke's encephalopathy: A case report and literature review","volume":"32","author":"Shang","year":"2017","journal-title":"Metab Brain Dis"},{"key":"R7-20260813","doi-asserted-by":"crossref","first-page":"260","DOI":"10.4103\/0022-3859.191005","article-title":"Wernicke's encephalopathy due to hyperemesis gravidarum: Clinical and magnetic resonance imaging characteristics","volume":"62","author":"Ashraf","year":"2016","journal-title":"J Postgrad Med"},{"key":"R8-20260813","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2214\/AJR.07.3959","article-title":"Neuroimaging findings in acute Wernicke's encephalopathy: Review of the literature","volume":"192","author":"Zuccoli","year":"2009","journal-title":"AJR Am J Roentgenol"},{"key":"R9-20260813","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3174\/ajnr.A1280","article-title":"MR imaging findings in 56 patients with Wernicke encephalopathy: Nonalcoholics may differ from alcoholics","volume":"30","author":"Zuccoli","year":"2009","journal-title":"AJNR Am J Neuroradiol"},{"key":"R10-20260813","first-page":"2301","article-title":"MR imaging of nonalcoholic Wernicke's encephalopathy: A follow-up study","volume":"26","author":"Zhong","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"R11-20260813","doi-asserted-by":"crossref","first-page":"31","DOI":"10.12968\/hmed.2011.72.1.31","article-title":"Wernicke's encephalopathy: A preventable cause of maternal death","volume":"72","author":"Wedisinghe","year":"2011","journal-title":"Br J Hosp Med (Lond)"},{"key":"R12-20260813","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.3109\/14767058.2011.629253","article-title":"Wernicke's encephalopathy complicating hyperemesis gravidarum: From the background to the present","volume":"25","author":"Di Gangi","year":"2012","journal-title":"J Matern Fetal Neonatal Med"},{"key":"R13-20260813","doi-asserted-by":"crossref","first-page":"e227530","DOI":"10.1136\/bcr-2018-227530","article-title":"Complete recovery in Wernicke's encephalopathy complicating hyperemesis gravidarum","volume":"12","author":"Aneja","year":"2019","journal-title":"BMJ Case Rep"},{"key":"R14-20260813","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/S0140-6736(99)00182-8","article-title":"Wernicke's encephalopathy induced by magnesium depletion","volume":"353","author":"McLean","year":"1999","journal-title":"Lancet"},{"key":"R15-20260813","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/s41430-020-0592-9","article-title":"Wernicke encephalopathy-a rare complication of hyperemesis gravidarum","volume":"74","author":"\u017digrai","year":"2020","journal-title":"Eur J Clin Nutr"},{"key":"R16-20260813","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.ajem.2019.09.012","article-title":"Wernicke encephalopathy associated with hyperemesis gravidarum","volume":"38","author":"Meggs","year":"2020","journal-title":"Am J Emerg Med"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1466_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:38:36Z","timestamp":1787845116000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1466_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_1466_20","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2020-07-17","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-28","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}