{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:38:02Z","timestamp":1786649882127,"version":"build-2736575974"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Subacute thyroiditis (SAT) is a self-limited inflammatory thyroid disease that follows or co-exists with a viral infection. COVID-19 has numerous multisystemic effects, including thyroid disorders. Possible mechanisms involved in COVID-19 infection-associated thyroid dysfunction include: apoptosis, inflammatory reaction and damage to follicular cells, direct effect of the virus, or interaction with thyroid angiotensin converting enzyme 2 (ACE2) receptors, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology and Results:<\/jats:title>\n                    <jats:p>In the period November 2021-February 2022, 12 patients with SAT associated with COVID-19 were evaluated in our department (11 women, one man); mean age 50 \u00b1 13.1 years. The mean time between COVID-19 infection and the onset of subacute thyroiditis was 23 \u00b1 10.2 days. The most common symptoms presented by affected patients were: fever, pain in the thyroid, and complaints associated with thyrotoxicosis. All patients presented severe inflammatory syndrome, but the clinical and biochemical picture of thyrotoxicosis was more severe compared to other viral subacute thyroiditis. In 60% of cases, 2D ultrasonography was suggestive for subacute thyroiditis, but the parameters of Share-Wave Elastography (SWE) confirmed the diagnosis in 100% of cases (mean thyroid stiffness 234.2 \u00b1 34.5 kPa). Under steroid therapy, during follow-up, thyroid stiffness gradually decreased at 4 weeks (130.38 \u00b1 15.4 kPa), respectively, at 8 weeks (64.7 \u00b1 5.3 kPa). The clinical outcome was favorable in all cases. Two patients developed hypothyroidism and were treated accordingly. SAT is characterized by a significantly increased stiffness of the thyroid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>The results of this study documented a significant difference in thyroid tissue stiffness between. SAT at baseline and values recorded at the follow-up visit. It should be noted that changes in the elastic properties of the thyroid parenchyma were associated with gradual normalization of biochemical parameters. The early diagnosis of SAT associated with COVID-19 is crucial, as prompt treatment with glucocorticoids leads to complete resolution of the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>SWE sonoelastography is useful in the positive diagnosis of subacute thyroiditis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_1542_24","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T13:01:21Z","timestamp":1767013281000},"page":"4984-4990","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Subacute thyroiditis after COVID-19 - Clinical, laboratory and ultrasound aspects"],"prefix":"10.4103","volume":"14","author":[{"given":"Ioana","family":"Golu","sequence":"first","affiliation":[{"name":"Centre for Molecular Research in Nephrology and Vascular Disease\/MOL-NEPHRO-VASC, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania (Golu, Balas, Milos, Vlad)"},{"name":"Department of Endocrinology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania (Golu, Balas, Milos, Vlad)"},{"name":"Department of Endocrinology, \u201cPius Brinzeu\u201d Emergency Hospital, 300182 Timisoara, Romania (Golu, Balas, Vlad)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melania","family":"Balas","sequence":"additional","affiliation":[{"name":"Centre for Molecular Research in Nephrology and Vascular Disease\/MOL-NEPHRO-VASC, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania (Golu, Balas, Milos, Vlad)"},{"name":"Department of Endocrinology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania (Golu, Balas, Milos, Vlad)"},{"name":"Department of Endocrinology, \u201cPius Brinzeu\u201d Emergency 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