{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:35:05Z","timestamp":1786649705500,"version":"build-2736575974"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Nevus comedonicus (NC), a rare developmental anomaly in the pilosebaceous unit, is characterized by grouped, dilated follicular orifices filled with keratinous material. NC is usually solitary but may be part of nevus comedonicus syndrome with extracutaneous abnormalities. This study aimed at comprehensively analyze and meticulously document demographic data, clinical presentations, and patterns of cutaneous involvement, concurrent dermatologic or systemic conditions, and complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>An observational study was conducted at a tertiary health centre for the period of one year. This study included patients clinically diagnosed with nevus comedonicus and subjected to further evaluation to rule out systemic involvement and pattern of cutaneous involvement and associated complication in these patients were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The study included nine patients diagnosed with nevus comedonicus, showing slight female preponderance and predominantly affecting the face. Clinical manifestations varied from asymptomatic to inflammatory or lesions leading to secondary complications such as bacterial superinfection, cyst formation in a few patients, and scarring in all the patients. All patients had single area of involvement, while the pattern of cutaneous involvement was mainly dermatomal in five patients. All patients had cosmetic disfigurement to some extent. No patient had any abnormalities of the eyes, skeleton, or central nervous system. None of the patients showed spontaneous resolution of nevus comedonicus, and lesions persisted after evolution. Therapeutic interventions offered to patients included a spectrum of modalities, including topical retinoids, keratolytics, systemic antibiotics, and surgical approaches such as incision and drainage of cysts, laser therapy, or surgical excision.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Nevus comedonicus is a rare cutaneous hamartoma with clustered, dilated pits filled with soft, black keratin. The study highlights demographic data, clinical presentations, and complications. Therapeutic options are variable, necessitating further research to understand the underlying pathophysiology and develop more effective treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_157_25","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T10:00:20Z","timestamp":1776679220000},"page":"1264-1269","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Exploring clustered comedones: Investigating rare cases of nevus comedonicus: An observational study"],"prefix":"10.4103","volume":"15","author":[{"given":"Mayur S.","family":"Dudhe","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Datta Meghe Medical College, Datta Meghe Institute of Higher Education and Research University (DU), Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabiha","family":"Quazi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Datta Meghe Medical College, Datta Meghe Institute of Higher Education and Research University (DU), Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sugat A.","family":"Jawade","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Datta Meghe Medical College, Datta Meghe Institute of Higher Education and Research University (DU), Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar M.","family":"Makhija","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Index Medical College, Hospital and Research Centre, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"R1-20260424","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.1365-2230.2007.02459.x","article-title":"Naevus comedonicus:A spectrum of body involvement","volume":"32","author":"Guldbakke","year":"2007","journal-title":"Clin Exp Dermatol"},{"key":"R2-20260424","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0045-9380(75)80010-7","article-title":"Epidermal and other congenital organic nevi","volume":"6","author":"Solomon","year":"1975","journal-title":"Curr Probl Pediatr"},{"key":"R3-20260424","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1001\/archderm.1968.01610140009002","article-title":"Nevus comedonicus. A case with palmar involvement and review of the literature","volume":"98","author":"Wood","year":"1968","journal-title":"Arch Dermatol"},{"key":"R4-20260424","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/BF00479677","article-title":"Naevus comedonicus","volume":"208","author":"Beerman","year":"1959","journal-title":"Arch Klin Exp Dermatol"},{"key":"R5-20260424","first-page":"418","article-title":"Nevus comedonicus. Report of a case with genital involvement","volume":"58","author":"Gonzalez-Martinez","year":"1996","journal-title":"Cutis"},{"key":"R6-20260424","doi-asserted-by":"crossref","first-page":"78","DOI":"10.2340\/0001555557880","article-title":"Nevus comedonicus. Report of three cases localized on glans penis","volume":"55","author":"Abdel-Aal","year":"1975","journal-title":"Acta Derm Venereol"},{"key":"R7-20260424","first-page":"409","article-title":"A case of bilateral naevus comedonicus. A contribution on histogenesis. (In German)","volume":"22","author":"Fritsch","year":"1971","journal-title":"Hautarzt"},{"key":"R8-20260424","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/00015558351","article-title":"Bilateral nevus comedonicus:Efficacy of topical tacalcitol ointment","volume":"83","author":"Wakahara","year":"2003","journal-title":"Acta Derm Venereol"},{"key":"R9-20260424","first-page":"674","article-title":"Treatment of nevus comedonicus with topical tazarotene and calcipotriene","volume":"3","author":"Deliduka","year":"2004","journal-title":"J Drugs Dermatol"},{"key":"R10-20260424","doi-asserted-by":"crossref","first-page":"422","DOI":"10.4103\/0019-5154.135533","article-title":"Inflammatory nevus comedonicus with epidermoid cyst","volume":"59","author":"Chhabra","year":"2014","journal-title":"Indian J Dermatol"},{"key":"R11-20260424","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.clindermatol.2010.09.012","article-title":"Blaschko lines and other patterns of cutaneous mosaicism","volume":"29","author":"Molho-Pessach","year":"2011","journal-title":"Clin Dermatol"},{"key":"R12-20260424","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1365-2133.1945.tb11217.x","article-title":"Linear comedo nevus and ichthyosis","volume":"57","author":"Piers","year":"1945","journal-title":"Br J Dermatol"},{"key":"R13-20260424","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1001\/archderm.1952.01530230095011","article-title":"Linear unilateral basal cell nevus with comedones","volume":"65","author":"Carney","year":"1952","journal-title":"AMA Arch Derm Syphilol"},{"key":"R14-20260424","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0190-9622(89)70301-7","article-title":"Nevus comedonicus associated with epidermal nevus","volume":"21","author":"Kim","year":"1989","journal-title":"J Am Acad Dermatol"},{"key":"R15-20260424","first-page":"250","article-title":"Naevus comedonicus associated with epidermoid cyst","volume":"62","author":"Mathur","year":"1996","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"R16-20260424","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1365-2133.1977.tb07160.x","article-title":"Trichilemmal cysts arising in an extensive comedo nevus","volume":"96","author":"Leppard","year":"1977","journal-title":"Br J Dermatol"},{"key":"R17-20260424","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2010.01.017","article-title":"The group of epidermal nevus syndromes Part I. Well defined phenotypes","volume":"63","author":"Happle","year":"2010","journal-title":"J Am Acad Dermatol"},{"key":"R18-20260424","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/S0190-9622(89)70039-6","article-title":"Treatment of nevus comedonicus with ammonium lactate lotion","volume":"20","author":"Milton","year":"1989","journal-title":"J Am Acad Dermatol"},{"key":"R19-20260424","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/S0140-6736(76)91685-8","article-title":"Treatment of lamellar ichthyosis and other keratinising dermatoses with an oral syntheticretinoid","volume":"27","author":"Peck","year":"1976","journal-title":"Lancet"},{"key":"R20-20260424","doi-asserted-by":"crossref","first-page":"361","DOI":"10.5021\/ad.2021.33.4.361","article-title":"Extensive nevus comedonicus with inflammatory nodules and cysts controlled with adalimumab","volume":"33","author":"Lee","year":"2021","journal-title":"Ann Dermatol"},{"key":"R21-20260424","doi-asserted-by":"crossref","first-page":"534","DOI":"10.4103\/0378-6323.55419","article-title":"Successful treatment of nevus comedonicus with ultrapulse CO2laser","volume":"75","author":"Sardana","year":"2009","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"R22-20260424","doi-asserted-by":"crossref","first-page":"33","DOI":"10.4103\/JCAS.JCAS_122_17","article-title":"Extensive nevus comedonicus, complicated with recurrent abscesses, successfully treated with surgical resurfacing","volume":"11","author":"Manikavachakan","year":"2018","journal-title":"J Cutan Aesthet Surg"},{"key":"R23-20260424","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/00000637-199210000-00015","article-title":"Tissue expansion in a patient with extensive nevus comedonicus","volume":"29","author":"Marcus","year":"1992","journal-title":"Ann Plast Surg"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_157_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:57:19Z","timestamp":1786647439000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_157_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_157_25","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-01-24","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}