{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:02:17Z","timestamp":1787169737503,"version":"build-2736575974"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The SARS-CoV-2 pandemic has emerged as the most challenging global health problem of this century. The concomitant presence of co-morbidities like chronic kidney disease (CKD), diabetes, CHD, further complicates the problem.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To assess the patterns of LFT abnormalities in patients of SARS-CoV-2 infection with and without CKD and evaluate the probable outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A cross-sectional retrospective observational study done on 600 patient samples (Group 1: SARS-CoV-2 without CKD, Group 2: SARS-CoV-2 with CKD and Group 3: CKD uninfected with SARS-CoV-2) which were processed for LFT and KFT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      AST and ALT were significantly higher in all SARS-CoV-2 infected; Group 1 mean \u00b1 2SD, (63.63 \u00b1 42.89U\/L &amp; 50.25 \u00b1 46.53U\/L), group 2 (90.59 \u00b1 62.51U\/L &amp; 72.09 \u00b1 67.24 U\/L) as compared to Group 3 (25.24 \u00b1 7.47U\/L &amp; 24.93 \u00b1 11.44U\/L). A statistically significant elevation is seen in these two parameters in Group 2 as compared to Group 1. There was a negative significant correlation between eGFR and AST\/ALT levels in Group 1 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05). In Group 2, a weak positive correlation was seen with ALT. Group 3, eGFR\u2019s showed strong correlations with AST and ALT levels; reduction in kidney function correlated well with increase in serum ALP levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study establishes that SARS-CoV-2 infected, with CKD, show higher elevations in serum aminotransferase levels in comparison to those without CKD. In contrast, the CKD group not infected, shows a decline in serum aminotransferase levels. Serum ALT values in SARS-CoV-2 show significant correlation with eGFR. Also, elevated ALP values in CKD patients may be used as an indicator of declining kidney function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_1594_21","type":"journal-article","created":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T11:54:47Z","timestamp":1645876487000},"page":"751-757","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["An evaluation of liver function tests in severe acute respiratory syndrome - Corona virus 2 (SARS-CoV-2) infection in the backdrop of chronic kidney disease"],"prefix":"10.4103","volume":"11","author":[{"given":"Rajeev","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Biochemistry, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratip","family":"Jana","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indu","family":"Priyadarshini","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smita","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pritha","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saswati","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, ABVIMS and Dr. RML Hospital, New Delhi, 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