{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:23:14Z","timestamp":1787757794970,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>Solitary pancreatic metastasis from renal cell carcinoma (RCC) is uncommon and may present decades after nephrectomy. We report an unusually late (17-year) solitary pancreatic metastasis from clear-cell RCC treated with curative resection. A 66-year-old man with a prior right nephrectomy 17 years earlier presented with 3 months of unintentional weight loss. Contrast-enhanced computed tomography (CECT) demonstrated an 8.0 \u00d7 5.0 cm hypervascular exophytic mass in the pancreatic neck body. Tumor markers (CEA, CA19-9) were within normal limits. Because of lesion vascularity, preoperative percutaneous biopsy was deferred. The patient underwent distal pancreatectomy with splenectomy. Gross and histology showed sheets of polygonal clear cells with prominent vasculature; immunohistochemistry was positive for CD10 and PAX8 and negative for synaptophysin and chromogranin, confirming metastatic clear-cell RCC. Resection margins were negative (R0). The patient declined adjuvant systemic therapy and remains disease-free at 36 months post-surgery. This case illustrates the potential for extremely late solitary pancreatic metastasis from RCC and underscores the importance of lifelong surveillance in RCC survivors. In selected patients, complete surgical resection can achieve durable disease control, even in the absence of adjuvant therapy.<\/jats:p>","DOI":"10.4103\/jfmpc.jfmpc_1600_25","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T14:01:09Z","timestamp":1779544869000},"page":"1842-1846","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Late solitary pancreatic metastasis from clear-cell renal cell carcinoma: A case report"],"prefix":"10.4103","volume":"15","author":[{"given":"Emil P.","family":"Mariantony","sequence":"first","affiliation":[{"name":"Department of General Surgery, AIIMS, Madurai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruthrendhra","family":"Ethirajulu","sequence":"additional","affiliation":[{"name":"Surgical Oncology, Iswarya Cancer Centre, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasikala","family":"Kathiresan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, AIIMS, Madurai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"R1-20260603","first-page":"39","article-title":"Renal cell carcinoma: An overview of the epidemiology, diagnosis, and treatment","author":"Bahadoram","year":"2022","journal-title":"G Ital Nefrol"},{"key":"R2-20260603","doi-asserted-by":"crossref","first-page":"695","DOI":"10.3390\/medicina60050695","article-title":"Revolutionizing the pancreatic tumor diagnosis: emerging trends in imaging technologies","volume":"60","author":"\u015eolea","year":"2024","journal-title":"Medicina"},{"key":"R3-20260603","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jclinepi.2017.04.026","article-title":"CARE guidelines for case reports: explanation and elaboration document","volume":"89","author":"Riley","year":"2017","journal-title":"J Clin Epidemiol"},{"key":"R4-20260603","doi-asserted-by":"crossref","first-page":"e38268","DOI":"10.1097\/MD.0000000000038268","article-title":"Therapeutic options for different metastatic sites arising from renal cell carcinoma: A review","volume":"103","author":"Wang","year":"2024","journal-title":"Medicine (Baltimore)"},{"key":"R5-20260603","doi-asserted-by":"crossref","first-page":"980","DOI":"10.5858\/arpa.2023-0358-RA","article-title":"Neoplastic progression in macroscopic precursor lesions of the pancreas","volume":"148","author":"Thompson","year":"2024","journal-title":"Arch Pathol Lab Med"},{"key":"R6-20260603","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/1097-0142(20000901)89:5<1076::AID-CNCR17>3.0.CO;2-M","article-title":"Renal cell carcinoma to the pancreas in surgical pathology material: A clinicopathologic study of 21 cases with a review of the literature","volume":"89","author":"Thompson","year":"2000","journal-title":"Cancer"},{"key":"R7-20260603","first-page":"e54973","article-title":"Isolated pancreatic metastasis from renal clear cell renal cell carcinoma 29 years after radical nephrectomy","volume":"16","author":"Fujiwara","year":"2024","journal-title":"Cureus"},{"key":"R8-20260603","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.3390\/cancers14061539","article-title":"Isolated pancreatic metastases of renal cell cancer: Genetics and epigenetics of an unusual tumour entity","volume":"14","author":"Sellner","year":"2022","journal-title":"Cancers (Basel)"},{"key":"R9-20260603","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1007\/s00261-018-01889-x","article-title":"Differentiation of pancreatic neuroendocrine tumors from pancreas renal cell carcinoma metastases on CT using qualitative and quantitative features","volume":"44","author":"van der Pol","year":"2019","journal-title":"Abdom Radiol (NY)"},{"key":"R10-20260603","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.hpb.2019.10.017","article-title":"Pancreatic resection for metastatic renal cell carcinoma. A systematic review","volume":"22","author":"Jaen-Torrejimeno","year":"2020","journal-title":"HPB (Oxford)"},{"key":"R11-20260603","doi-asserted-by":"crossref","first-page":"709","DOI":"10.3389\/fonc.2020.00709","article-title":"Isolated pancreatic metastases of renal cell carcinoma: A paradigm of a seed and soil mechanism","volume":"10","author":"Sellner","year":"2020","journal-title":"Front Oncol"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1600_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:53:54Z","timestamp":1787756034000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1600_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_1600_25","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-08-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-25","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}