{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:26:27Z","timestamp":1787840787083,"version":"build-2784847793"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Bone mineral density (BMD) is affected in diabetes, and we studied the changes in BMD in children with type 1 diabetes mellitus (T1DM) and matched controls. We also assessed the impact of diabetes duration on BMD using the Dual-energy X-ray absorptiometry (DXA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this single-centre, case-control study, we included 30 children and adolescents aged between 6 and 18 years with a T1DM duration of more than 6 months and a similar number of age, sex, and puberty-matched healthy controls. All the participants underwent a detailed clinical and biochemical evaluation and the BMD was assessed by DXA. The results were analysed by appropriate statistical methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The study population (14 M: 16F) had a mean (SD) age of 11.9 (3.8) years, T1DM duration of 2.7 (2) years and HbA1c of 11.2 (2.7) percent. The BMD (gm\/cm\n                      <jats:sup>2<\/jats:sup>\n                      ) at total body less head (TBLH) and lumbar spine (LS) was 0.63 (0.13), 0.59 (0.15) in cases and 0.65 (0.12), 0.62 (0.15) in controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.473), respectively. The duration of diabetes did not show significant correlation with the BMD (r = 0.328,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.077). BMD is correlated positively with physical activity and negatively with screen time in both cases and controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study did not find a significant difference in BMD between children with T1DM and matched controls. However, it showed the importance of physical activity and screen time for bone health in children, irrespective of diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_1637_24","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T12:01:43Z","timestamp":1774008103000},"page":"740-745","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Bone mineral density in children and adolescents with type 1 diabetes: A case-control study from South India"],"prefix":"10.4103","volume":"15","author":[{"given":"Sayyad","family":"Aleem","sequence":"first","affiliation":[{"name":"Department of Endocrinology, ESIC Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KVS","family":"Hari Kumar","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, ESIC Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Guddeti","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, ESIC Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naseemuddin Nayeemuddin","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, ESIC Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, ESIC Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai Ramya","family":"Vasamsetti","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, ESIC Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anushri","family":"Sridharan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, ESIC Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sravanthi","family":"Mashetty","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, ESIC Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"key":"R1-20260325","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S2213-8587(22)00218-2","article-title":"Global incidence, prevalence, and mortality of type 1 diabetes in 2021 with projection to 2040:A modelling study","volume":"10","author":"Gregory","year":"2022","journal-title":"Lancet Diabetes 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