{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:17:37Z","timestamp":1794003457881,"version":"4.8.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Brucellosis is a neglected zoonotic disease of major public health concern. In India, the incidence of brucellosis remains vastly underreported due to its non-specific clinical presentation and sub-optimal sensitivity of existing gold standard tests. Studies in Northeast India have shown high incidences of brucellosis in livestock, but the region lacks data on human brucellosis despite its high associated risk. In the present study, we report the seroprevalence of human brucellosis and its associated risk factors in Meghalaya, Northeast India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A prospective observational study was conducted in East Khasi Hills and Ri.Bhoi districts of Meghalaya, from July 2018 to July 2020. A total of 1046 suspected patients with febrile illness along with associated risk factors were recruited through camps and various diagnostic laboratories in the defined region as per the pre.specified inclusion and exclusion criteria. Baseline, demographics, and clinical characteristics were recorded of all the consenting participants. Blood samples were analyzed for brucellosis-specific IgM antibodies through enzyme-linked immunosorbent assay (ELISA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and discussion:<\/jats:title>\n                    <jats:p>The overall seroprevalence of brucellosis was found to be 11.37% in Meghalaya. Among recruited participants, females were found to be more susceptible than males. Risk factors such as consumption of meat were found to be more significantly associated with brucellosis disease in the study region. Among the clinical presentations, pyrexia of unknown origin, myalgia, and chronic fatigue syndrome were found to be significantly associated with brucellosis disease in IgM.positive cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our result suggests further epidemiological investigations for human brucellosis in Northeast India toward improved advocacy for accurate diagnosis, and development of proper response mechanism in areas of high endemicity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_1705_21","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T07:34:07Z","timestamp":1666164847000},"page":"5176-5186","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":17,"title":["Seroepidemiological study of human brucellosis in the Northeast region of Meghalaya, India"],"prefix":"10.4103","volume":"11","author":[{"given":"Jayshree L.","family":"Shukla","sequence":"first","affiliation":[{"name":"Research Centre, Dr. G.M. Taori Central India Institute of Medical Sciences, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliabbas A.","family":"Husain","sequence":"additional","affiliation":[{"name":"Research Centre, Dr. G.M. Taori Central India Institute of Medical Sciences, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha A.","family":"Lyngdoh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, North-Eastern Hill University, Shillong, Meghalaya, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavius P.","family":"Nonglang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, North-Eastern Hill University, Shillong, Meghalaya, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Sahai","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, North-Eastern Hill University, Shillong, Meghalaya, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manasjit","family":"Gogoi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, North-Eastern Hill University, Shillong, Meghalaya, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lokendra R.","family":"Singh","sequence":"additional","affiliation":[{"name":"Research Centre, Dr. G.M. Taori Central India Institute of Medical Sciences, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surya","family":"Bhan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, North-Eastern Hill University, Shillong, Meghalaya, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajpal S.","family":"Kashyap","sequence":"additional","affiliation":[{"name":"Research Centre, Dr. G.M. Taori Central India Institute of Medical Sciences, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,10,14]]},"reference":[{"key":"B1-20240828","first-page":"9","article-title":"Seroprevalence and associated risk factors of human brucellosis from a tertiary care hospital setting in Central India","volume":"4","author":"Shukla","year":"2020","journal-title":"J Zoo Diseases"},{"key":"B2-20240828","first-page":"85","article-title":"Brucellosis in North India: Results of a prospective study","volume":"30","author":"Handa","year":"1998","journal-title":"J Commun Dis"},{"key":"B3-20240828","doi-asserted-by":"crossref","first-page":"23846","DOI":"10.3402\/ehtj.v7.23846","article-title":"Human brucellosis among pyrexia of unknown origin cases and occupationally exposed individuals in Goa Region, India","volume":"7","author":"Pathak","year":"2014","journal-title":"Emerg Health Threats J"},{"key":"B4-20240828","doi-asserted-by":"crossref","first-page":"271","DOI":"10.4103\/0377-4929.97913","article-title":"Seroprevalence of brucellosis: A 10-year experience at a tertiary care center in North India","volume":"55","author":"Appannanavar","year":"2012","journal-title":"Indian J Pathol Microbiol"},{"key":"B5-20240828","first-page":"BC9","article-title":"Incidence of neurobrucellosis from Central India: A hospital based study","volume":"30","author":"Tembhurne","year":"2018","journal-title":"J Clin Diagnostic Res"},{"key":"B6-20240828","first-page":"199","article-title":"Epidemiology of brucellosis in India: A review","volume":"17","author":"Upadhyay","year":"2019","journal-title":"Pantnagar J Res"},{"key":"B7-20240828","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s12038-008-0072-1","article-title":"Brucellosis in India-A review","volume":"33","author":"Mantur","year":"2008","journal-title":"J Biosci"},{"key":"B8-20240828","doi-asserted-by":"crossref","first-page":"350","DOI":"10.4103\/0975-2870.118265","article-title":"Human Brucellosis: Are we neglecting an enemy at the backyard?","volume":"6","author":"Pandit","year":"2013","journal-title":"Med J DY Patil Univ"},{"key":"B9-20240828","first-page":"1","article-title":"Sero-prevalence of brucellosis in cattle and its associated risk factors in North East India (Meghalaya)","volume":"27","author":"Kylla","year":"2017","journal-title":"Int J Trop Dis Health"},{"key":"B11-20240828","first-page":"474","article-title":"Incidence of brucellosis in Livestock in North-Eastern India","volume":"45","author":"Shakuntala","year":"2016","journal-title":"J Glob Infect Dis"},{"key":"B12-20240828","first-page":"179","article-title":"Prevalence of bovine brucellosis in Assam, India","volume":"5","author":"Gogoi","year":"2017","journal-title":"J Entomol Zool Stud"},{"key":"B13-20240828","doi-asserted-by":"crossref","first-page":"104239","DOI":"10.1100\/2012\/104239","article-title":"Seroprevalence study of human brucellosis by conventional tests and indigenous indirect enzyme-linked immunosorbent assay","volume":"2012","author":"Agasthya","year":"2012","journal-title":"ScientificWorldJournal"},{"key":"B14-20240828","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1476-072X-10-52","article-title":"Spatial epidemiology of hospital-diagnosed brucellosis in Kampala, Uganda","volume":"10","author":"Makita","year":"2011","journal-title":"Int J Health Geogr"},{"key":"B15-20240828","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0140-6736(67)92914-5","article-title":"Serological investigations in suspected brucellosis","volume":"1","author":"Mac Donald","year":"1967","journal-title":"Lancet"},{"key":"B16-20240828","doi-asserted-by":"crossref","first-page":"219","DOI":"10.5144\/0256-4947.1999.219","article-title":"Seroepidemiology survey of brucellosis antibodies in Saudi Arabia","volume":"19","author":"Al-Sekeit","year":"1999","journal-title":"Ann Saudi Med"},{"key":"B17-20240828","first-page":"427","article-title":"Trend of human brucellosis over a decade at tertiary care centre in North Karnataka","volume":"34","author":"Patil","year":"2017","journal-title":"Indian J Med Microbiol"},{"key":"B18-20240828","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0378-1135(02)00253-5","article-title":"Epidemiology, zoonotic aspects, vaccination and control\/eradication of brucellosis in India","volume":"90","author":"Renukaradhya","year":"2002","journal-title":"Vet Microbiol"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1705_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:12:10Z","timestamp":1787757130000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1705_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_1705_21","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"2021-08-25","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-04","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}