{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:38:10Z","timestamp":1786649890101,"version":"build-2736575974"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Vulvar carcinoma is primarily a disease of post-menopausal women. Surgery is a primary treatment strategy. Chemotherapy and radiotherapy are a part of multimodal therapy. Presently, there is a shift towards neoadjuvant chemotherapy or radiotherapy so as to decrease the surgical morbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To study the surgical outcome and prognostic factors in Ca vulva patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>A retrospective analysis of 19 vulvar cancer patients, surgically treated at a teaching institution of Punjab (2009\u20132019).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Mean age of the patients was 60.95 years. Ulcerative swelling (89.5%) over labia majora (73.7%) was the main presenting symptom. Radical vulvectomy-bilateral IFLN dissection was performed in 74% patients, hemivulvectomy-unilateral IFLN dissection in 21% patients and wide local excision in one patient. Squamous cell carcinoma was detected in all, and one had verrucous carcinoma. Thirty-seven per cent patients had FIGO stage III disease, 31.5% - stage II and 31.5% - stage I. On HPE, 78.57% (11\/14) patients had positive nodes and two had ECS. Only 5\/9 (55.5%) cases could receive PORT. Seven patients defaulted follow-up. Two developed nodal metastasis, and seven women developed recurrence. One patient with regional recurrence faced demise during RT course. In 10\/19 regular follow-up patients, four are alive and disease free, five patients are on palliative chemoradiation, and one is undergoing adjuvant radiotherapy for regional recurrence. Estimated 5-year overall survival is 83.33%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Tumour stage, nodal positivity and nodal ECS were poor prognostic factors. Radical surgery-extensive groin node dissection causes significant morbidity; hence, studies evaluating the role of neoadjuvant treatment are needed so as to modify current treatment practices. HPV vaccination as a preventive measure and a thorough and extensive evaluation of patients with suspicious signs in vulvar disease is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_1731_22","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T07:52:27Z","timestamp":1682495547000},"page":"654-659","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Carcinoma vulva: Ten years experience in a teaching institution of North India"],"prefix":"10.4103","volume":"12","author":[{"given":"Lajya Devi","family":"Goyal","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Bathinda, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balpreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Bathinda, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivali","family":"Bhalla","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Civil Hospital, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pardeep","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"R1-20260109","first-page":"11","article-title":"Cancer statistics","volume":"63","author":"Siegel","year":"2013","journal-title":"CA Cancer J Clin"},{"key":"R2-20260109","first-page":"394","article-title":"Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"R3-20260109","article-title":"Cancer Incidence and Mortality in Chennai, India:2006\u20132008, National Cancer Registry Program, Cancer Institute (WIA), Chennai, India,","author":"Swaminathan","year":"2010"},{"key":"R4-20260109","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/GME.0000000000001687","article-title":"Age-associated trends of vulvar cancer in the US","volume":"28","author":"Khadraoui","year":"2020","journal-title":"Menopause"},{"key":"R5-20260109","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s13193-019-00887-9","article-title":"Surgical management of carcinoma vulva-case series and review of literature","volume":"10","author":"Lakhwani","year":"2019","journal-title":"Indian JSurg Oncol"},{"key":"R6-20260109","doi-asserted-by":"crossref","first-page":"e019005","DOI":"10.1136\/bmjopen-2017-019005","article-title":"Long term incidence trends of HPV-related cancers, and cases preventable by HPV vaccination:A registry-based study in Norway","volume":"8","author":"Hansen","year":"2018","journal-title":"BMJ Open"},{"key":"R7-20260109","first-page":"212","article-title":"Cancer statistics,","volume":"61","author":"Siegel","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"R9-20260109","doi-asserted-by":"crossref","first-page":"412","DOI":"10.4103\/0019-509X.200656","article-title":"A cohort study of vulvar cancer over a period of 10 years and review of literature","volume":"53","author":"Singh","year":"2016","journal-title":"Indian J Cancer"},{"key":"R10-20260109","doi-asserted-by":"crossref","first-page":"121","DOI":"10.6004\/jnccn.2017.0009","article-title":"Surgical management of vulvar cancer","volume":"15","author":"Dellinger","year":"2017","journal-title":"J NatlCompr Canc Netw"},{"key":"R11-20260109","first-page":"S76","article-title":"Cancer of the vulva","volume":"131","author":"Hacker","year":"2015","journal-title":"Int J Gynecol Obstet"},{"key":"R12-20260109","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ygyno.2004.09.016","article-title":"Single agent cisplatin chemotherapy in surgically resected vulvar cancer patients with multiple inguinal lymph node metastases","volume":"96","author":"Bellati","year":"2005","journal-title":"Gynecol Oncol"},{"key":"R14-20260109","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s13224-019-01261-z","article-title":"An overview of vulvar cancer:A single-center study from Northeast India","volume":"69","author":"Nandwani","year":"2019","journal-title":"J Obstet Gynaecol India"},{"key":"R15-20260109","first-page":"4","article-title":"Cancer of the vulva. 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