{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:27:45Z","timestamp":1786739265226,"version":"build-2736575974"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Hepatitis B virus (HBV) infection is a serious public health issue that must be addressed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The goal of this study was to investigate the correlation between serological status for hepatitis Be antigen (HBeAg)\/anti-HBe, serum transaminase levels, and serum HBV-DNA in patients with chronic HBV infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective observational study with 620 patients with persistent HBV infection (mean age, 36.35 years; 506 men) was conducted. All patients tested positive for hepatitis B surface antigen (HBsAg). Liver profile, HBeAg, and anti-HBe antibody tests were conducted for all patients. Additionally, serum HBV DNA was examined using a DNA assay in these individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of 620 patients, 114 (18.39%) were HBeAg-positive and 506 (81.61%) HBeAg-negative. A detectable level of HBV DNA was found in 89.79% of HBeAg-positive\/anti-HBe negative patients compared to HBeAg-negative\/anti-HBe positive carriers 33.69% (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value &lt;0.0001). The median viral load was significantly higher in HBeAg-positive cases (4.72 log10 copies\/mL) than in HBeAg-negative individuals (4.23 log10 copies\/mL;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.997). Additionally, a higher proportion of HBeAg-positive samples (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0001) had HBV-DNA levels above 10,000 copies\/mL.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_1746_23","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T06:09:06Z","timestamp":1718345346000},"page":"2410-2415","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Seroepidemiology of hepatitis B virus (HBV) and relationship to serum transaminase levels in Indian population"],"prefix":"10.4103","volume":"13","author":[{"given":"Manoj","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Microbiology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumari","family":"Seema","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok Kumar","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manju","family":"Boipai","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysha","family":"Rani","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"R2-20260204","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1046\/j.1365-2893.2003.00487.x","article-title":"Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures","volume":"11","author":"Lavanchy","year":"2004","journal-title":"J Viral 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Annual"},{"key":"R24-20260204","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1017\/S0950268803008574","article-title":"Seroepidemiology of hepatitis B virus in Addis Ababa, Ethiopia: Transmission patterns and vaccine control","volume":"131","author":"Abebe","year":"2003","journal-title":"Epidemiol Infect"},{"key":"R25-20260204","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3329\/bmrcb.v34i2.1173","article-title":"HBeAg\/anti-HBe, alanine aminotransferase and HBV DNA levels in HBsAg positive chronic carriers","volume":"34","author":"Rabbi","year":"2008","journal-title":"Bangladesh Med Res Counc Bull"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1746_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:27:23Z","timestamp":1786735643000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1746_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_1746_23","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"2023-10-28","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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