{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:24:33Z","timestamp":1787757873582,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>\n                      Implantation failure is a major problem in reproductive medicine, and despite the various methods described for treatment, there is little consensus on the most effective method. This study was conducted to investigate the effect of intrauterine injection of platelet-rich plasma (PRP) on the pregnancy rate of patients with a history of implantation failure in the\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      fertilization (IVF) cycle.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>In this study, women attending the infertility clinic of Ali ibn Abi Taleb Hospital, who had a history of implantation failure and were candidates for frozen embryo transfer (FET), were examined in Zahedan (Iran) in 2019. The patients were divided into two groups of PRP recipients and the control group. IVF was performed routinely, and in the PRP-receiving group, an intrauterine injection was given 48 h before embryo transfer (ET). The number of gestational sacs, the rate of implantation, the frequency of chemical and clinical pregnancies as well as the frequency of abortion were compared in the two groups. The collected data were analyzed by the SPSS software version 21<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Ninety patients with a history of implantation failure participated in the study, and finally, the information of 85 patients was studied. The frequency of chemical pregnancy was 40% in the experimental group, 27% in the control group, and regarding clinical pregnancy, 33% in the experimental group and 24% in the control group, but there was no significant difference between the two groups. The rate of implantation, the mean thickness of the endometrium, and the frequency of abortion did not differ significantly between the two groups<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In patients with endometrial thickness greater than 8 mm with a history of recurrent implantation failure, intrauterine injection of PRP had no effect on the fertility outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_1817_21","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T07:41:10Z","timestamp":1653464470000},"page":"2162-2166","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":20,"title":["Evaluation of the effect of intrauterine injection of platelet-rich plasma on the pregnancy rate of patients with a history of implantation failure in the in vitro fertilization cycle"],"prefix":"10.4103","volume":"11","author":[{"given":"Sara","family":"Ershadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narjes","family":"Noori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Dashipoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzieh","family":"Ghasemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahid","family":"Shamsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-91-20240828","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4103\/0974-1208.97777","article-title":"Understanding implantation window, a crucial phenomenon","volume":"5","author":"Sharma","year":"2012","journal-title":"J Hum Reprod Sci"},{"key":"R2-91-20240828","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12958-018-0414-2","article-title":"Recurrent implantation failure-update overview on etiology, diagnosis, treatment and future directions","volume":"16","author":"Bashiri","year":"2018","journal-title":"Reprod Biol Endocrinol"},{"key":"R3-91-20240828","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4103\/tofj.tofj_11_18","article-title":"Intrauterine autologous platelet-rich plasma therapy to improve implantation rates in patients undergoing frozen embryo transfer: A pilot study","volume":"1","author":"Madhavan","year":"2018","journal-title":"Onco Fertil J"},{"key":"R4-91-20240828","first-page":"30","article-title":"Using autologous intrauterine platelet-rich plasma to improve the reproductive outcomes of women with recurrent implantation failure","volume":"24","author":"Aghajanzadeh","year":"2020","journal-title":"JBRA Assist Reprod"},{"key":"R5-91-20240828","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s40618-017-0802-z","article-title":"Age-specific reference values and cut-off points for anti-m\u00fcllerian hormone in infertile women following a long agonist treatment protocol for IVF","volume":"41","author":"Hiedar","year":"2018","journal-title":"J Endocrinol Invest"},{"key":"R6-91-20240828","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.fertnstert.2018.09.020","article-title":"Innovations in assisted reproductive technologies: Impact on contemporary donor egg practice and future advances","volume":"110","author":"Christianson","year":"2018","journal-title":"Fertil Steril"},{"key":"R7-91-20240828","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1093\/humrep\/deh755","article-title":"Assisted reproductive technology in Europe, 2001. 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