{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:27:12Z","timestamp":1787758032397,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Although vaccination with vector-based or mRNA-based SARS-CoV-2 vaccines is usually well tolerated, they are not free of side effects. Some of these side effects can be severe and concern the primary care physician, otorhinolaryngologist, and the neurologist. Persisting, unilateral tinnitus time-linked to the first dose and worsening after the second dose of an mRNA-based SARS-CoV-2 vaccine has not been reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Case report.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Routine tests were applied to investigate the patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A 35-year-old male experienced sudden onset of right-sided tinnitus, diffuse headache, and ear respectively facial pressure 22 days after the first dose of an mRNA-based SARS-CoV-2 vaccine. Since symptoms worsened after the second dose, 28 days later, the patient started a self-medication with non-steroidal anti-inflammatory drugs, without benefit. After an otolaryngologist suspected Meniere\u2019s disease, prednisone was given for 5 days with significant improvement. After discontinuation of steroids, however, previous symptoms recurred with similar intensity as before. Cetirizin and loratadin were started resulting in complete resolution of headache and pressures but persistence of tinnitus. After exclusion of various differentials, a causal relation between clinical presentation and vaccination was suspected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>SARS-CoV-2 vaccination can be followed by unilateral persisting tinnitus, headache, and ear respectively facial pressure. Since steroids and anti-histamines had a beneficial effect, an immunological pathophysiology is quite likely.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_1927_21","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T10:17:00Z","timestamp":1656584220000},"page":"3330-3332","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Persisting, unilateral tinnitus 22 days after first dose of an mRNA-based SARS-CoV-2 vaccine"],"prefix":"10.4103","volume":"11","author":[{"given":"Josef","family":"Finsterer","sequence":"first","affiliation":[{"name":"Neurology and Neurophysiology Center, Vienna, Austria, Europe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Edmonds","sequence":"additional","affiliation":[{"name":"Catharus Scientific LLC, Tularosa, NM, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"B1-20240828","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13037-021-00291-9","article-title":"Review the safety of Covid-19 mRNA vaccines: A review","volume":"15","author":"Anand","year":"2021","journal-title":"Patient Saf Surg"},{"key":"B2-20240828","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/ane.13451","article-title":"SARS-CoV-2 vaccines are not free of neurological side effects","volume":"144","author":"Finsterer","year":"2021","journal-title":"Acta Neurol Scand"},{"key":"B3-20240828","first-page":"e13426","article-title":"Neurological complications of COVID-19: Guillain-Barre syndrome following Pfizer COVID-19 vaccine","volume":"13","author":"Waheed","year":"2021","journal-title":"Cureus"},{"key":"B4-20240828","article-title":"Exacerbating Guillain-Barre syndrome eight days after vector-based COVID-19 vaccination","author":"Finsterer","year":"2021","journal-title":"Case Rep Infect Dis 2021"},{"key":"B5-20240828","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1002\/ana.26065","article-title":"ANA investigates: Neurological complications of COVID-19 vaccines","volume":"89","author":"Goss","year":"2021","journal-title":"Ann Neurol"},{"key":"B6-20240828","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.puhe.2021.01.011","article-title":"Vaccines for COVID-19: Learning from ten phase II trials to inform clinical and public health vaccination programmes","volume":"193","author":"Bhopal","year":"2021","journal-title":"Public Health"},{"key":"B7-20240828","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/ane.13550","article-title":"Neurological side effects of SARS-CoV-2 vaccinations","volume":"145","author":"Finsterer","year":"2022","journal-title":"Acta Neurol Scand"},{"key":"B8-20240828","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1093\/qjmed\/hcab210","article-title":"The reversible tinnitus and cochleopathy followed first-dose AstraZeneca COVID-19 vaccination","volume":"114","author":"Tseng","year":"2021","journal-title":"QJM"},{"key":"B9-20240828","article-title":"Acute thyroiditis and bilateral optic neuritis following SARS-CoV-2 vaccination with CoronaVac: A case report","volume":"1","author":"Leber","year":"2021","journal-title":"Ocul Immunol Inflamm"},{"key":"B10-20240828","doi-asserted-by":"crossref","first-page":"e242344","DOI":"10.1136\/bcr-2021-242344","article-title":"Trigeminal and cervical radiculitis after tozinameran vaccination against COVID-19","volume":"14","author":"Narasimhalu","year":"2021","journal-title":"BMJ Case Rep"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1927_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:02:30Z","timestamp":1787756550000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_1927_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_1927_21","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"2021-09-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-24","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}