{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:30:56Z","timestamp":1786739456544,"version":"build-2736575974"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n Acute appendicitis is the most common abdominal surgical emergencies across the world.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n The aim of this study was to determine the value of C-reactive protein (CRP) and D-dimer as diagnostic markers of acute appendicitis.<\/jats:p>\n <\/jats:sec>\n \n Study Design:<\/jats:title>\n It was a Prospective observational clinical study.<\/jats:p>\n <\/jats:sec>\n \n Method:<\/jats:title>\n The present study was carried out in General Surgical Unit of University Hospital, Institute of Medical Sciences, Banaras Hindu University, Varanasi from September 2015 to July 2017. All data including patient's demography, clinical examination, laboratory test results, and appendix histology were summarized. Receiver operating characteristic (ROC) curve of TLC, CRP, and D-dimer was analyzed.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Total 65 patients who presented with periumbilical pain or pain in right iliac fossa (RIF) were included in the study. The mean age of the patients was 31.18 \u00b1 14.59 years (range: 15 to 65 years) with male : female ratio was 2.21:1. The most common symptom was pain in right iliac fossa (100%) followed by nausea\/vomiting (69.2%). The mean leucocyte count, CRP, and D-dimer levels were significantly raised in appendicitis group as compared to negative appendicectomy group (\n P<\/jats:italic>\n = 0.025,\n P<\/jats:italic>\n = 0.036, and\n P<\/jats:italic>\n = 0.025, respectively). The receiver operating characteristic (ROC) curve for TLC was not helpful for differentiating between appendicitis and negative appendicitis (\n P<\/jats:italic>\n = 0.073). In addition, D-dimer was helpful for differentiating between appendicitis and negative appendicitis (\n P<\/jats:italic>\n = 0.002). However, CRP was also found to be helpful for differentiating between appendicitis and negative appendicitis (\n P<\/jats:italic>\n = 0.030).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The diagnosis of appendicitis remains multifactorial and biochemical markers like CRP and D-dimer may help to guide the surgeon in the decision making.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_197_20","type":"journal-article","created":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T10:08:40Z","timestamp":1595758120000},"page":"3492-3495","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["A study of C-reactive protein and D-dimer in patients of appendicitis"],"prefix":"10.4103","volume":"9","author":[{"given":"Satendra","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayant","family":"Maurya","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandip","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashi Kant","family":"Patne","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit Nandan Dhar","family":"Dwivedi","sequence":"additional","affiliation":[{"name":"Department of Radio-Diagnosis and Imaging, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,7]]},"reference":[{"key":"R3-20260813","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1136\/pgmj.41.471.2","article-title":"The diagnosis of appendicitis","volume":"41","author":"Smith","year":"1965","journal-title":"Postgrad Med J"},{"key":"R4-20260813","doi-asserted-by":"crossref","first-page":"349e52","DOI":"10.1148\/radiology.215.2.r00ma24337","article-title":"Appendicitis at the millennium","volume":"215","author":"Birnbaum","year":"2000","journal-title":"Radiology"},{"key":"R5-20260813","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00423-007-0239-5","article-title":"Procalcitonin in preoperative diagnosis of abdominal sepsis","volume":"393","author":"Ivancevi\u0107","year":"2008","journal-title":"Langenbecks Arch 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appendicitis- a meta-analysis","volume":"57","author":"Hallan","year":"1997","journal-title":"Scand J Clin Lab Invest"},{"key":"R17-20260813","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1046\/j.1365-2168.1999.01063.x","article-title":"Leucocyte count and C-reactive protein in the diagnosis of acute appendicitis","volume":"86","author":"Gr\u00f6nroos","year":"1999","journal-title":"Br J Surg"},{"key":"R18-20260813","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s10350-008-9265-9","article-title":"Usefulness of laboratory data in the management of right iliac fossa pain in adults","volume":"51","author":"Ortega-Deballon","year":"2008","journal-title":"Dis Colon Rectum"},{"key":"R19-20260813","article-title":"Procalcitonin as an excellent differential marker between uncomplicated and complicated acute appendicitis in adultpatients","author":"Li","year":"2019","journal-title":"Eur J Trauma Emerg 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